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Sigal Irving S, Huff Joel R, Darke Paul L, Vacca Joseph P, Young Steven D, Desolms S Jane, Thompson Wayne J, Lyle Terry A, Graham Samuel L, Ghosh Arun K: Hiv protease inhibitors useful for the treatment of aids.. Merck & Co, October 18, 1989: EP0337714-A2 (242 worldwide citation)

Compounds of the form A-G-B-B-J wherein A is an amine protecting group commonly employed in peptide synthesis, G a dipeptide isostere, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatm ...


2
Thompson Wayne J, Vacca Joseph P, Huff Joel R, Lyle Terry A, Young Steven D, Hungate Randall W, Britcher Susan F, Ghosh Arun K: Hiv protease inhibitors useful for the treatment of aids.. Merck & Co, June 26, 1991: EP0434365-A2 (69 worldwide citation)

Compounds of the form, A-G-B-B-J wherein A is an amine protecting group or urethane, G a dipeptide isostere substituted with a basic amine nitrogen, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the preven ...


3
Thompson Wayne J, Ghosh Arun K, Lee Hee Yoon, Huff Joel R: Hiv protease inhibitors.. Merck & Co, April 28, 1993: EP0539192-A1 (42 worldwide citation)

Oligopeptide analogs are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination w ...


4
Bao Jianming, Kayser Frank, Kotliar Andrew, Parsons William H, Rupprecht Kathleen M, Claiborne Christopher F, Liverton Nigel, Claremon David A, Thompson Wayne J: Heterocyclic potassium channel inhibitors. Merck & Co, August 29, 2001: EP1126849-A1 (12 worldwide citation)

The present invention relates to a class of heterocyclic compounds of Formula (I) that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like.


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Ghosh Arun K, Huff Joel R, Thompson Wayne J, Lyle Terry A, Hungate Randall W, Mckee Sean P, Lee Hee Yoon: Hiv protease inhibitors useful for the treatment of aids.. Merck & Co, March 31, 1993: EP0534511-A1 (10 worldwide citation)

Compounds of the form, A-G-J wherein A is an amine protecting group or urethane, G a dipeptide isostere and J a small terminal group are described. They are distinguished by tetrahydrofuryl or tetrahydropyranyl substituents, and the like. These compounds are useful in the inhibition of HIV protease, ...


6
Thompson Wayne J, Thompson David D, Anderson Paul S, Rodan Gideon A: Polymalonic acids as boneaffinity agents.. Merck & Co, November 15, 1989: EP0341961-A2 (10 worldwide citation)

The invention relates to novel polymalonic acids which act as bone-affinity agents. Compounds of the formula have a high affinity for bone and are useful in the treatment and prevention of diseases involving bone resorption, particularly osteoporosis, Paget's disease, and malignant hypercalcemia, by ...


7
Treiber Laszlo R, Dezeny Georgette, Colwell Lawrence F, Lingham Russell B, Arison Byron H, Thompson Wayne J, Balani Suresh Kumar: Inhibitors of hiv protease.. Merck & Co, April 15, 1992: EP0480711-A1 (10 worldwide citation)

A dipeptide isostere is the biotransformed product after incubation with a culture of Streptomyces. It inhibits HIV protease, and is useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as a compound, pharmaceutically acceptable salt, pharmaceutical composition ...


8
Britcher Susan F, Lyle Terry A, Thompson Wayne J, Varga Sandor L: Derivatives of 5-methyl-10,11-dihydro-5h-dibenzo-(a,d) cyclohepten-5,10-imine.. Merck & Co, April 20, 1988: EP0264183-A1 (5 worldwide citation)

Fluoro-and hydroxy-derivatives of 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines wherein the substituents are on non-benzenoid carbons are active anticonvulsants and antagonists of N-methyl-D-aspartate.


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Thompson Wayne J, Melamed Jeffrey Y: Morpholine carboxamide prokineticin receptor antagonists. Merck & Co, Thompson Wayne J, Melamed Jeffrey Y, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, June 14, 2007: WO/2007/067511 (3 worldwide citation)

The present invention is directed to morpholine carboxamide compounds which are antagonists of prokineticin receptors, in particular antagonists of prokineticin 2 receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which prokinetic ...


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