1
John S Kent, Danny H Lewis, Lynda M Sanders, Thomas R Tice: Microencapsulation of water soluble active polypeptides. Syntex, Ellen J Wise, Tom M Moran, Alan Krubiner, June 23, 1987: US04675189 (321 worldwide citation)

This invention concerns novel sustained release microcapsule compositions comprising water-soluble, hormonally active polypeptides and, optionally, a polymer hydrolysis modifying agent encapsulated in a biocompatible, biodegradable polymer.


2
Thomas R Tice, Danny H Lewis: Microencapsulation process. Stolle Research and Development Corporation, Oblon Fisher Spivak McClelland & Maier, June 21, 1983: US04389330 (264 worldwide citation)

Microcapsules laden with an active agent are prepared by a method comprising: (a) dissolving or dispersing an active agent in a solvent and dissolving a wall forming material in said solvent; (b) dispersing said solvent containing said active agent and wall forming material in a continuous-phase pro ...


3
Thomas R Tice, Richard M Gilley: Drug delivery system and method of making the same. Southern Research Institute, Needle & Rosenberg, January 30, 1990: US04897268 (251 worldwide citation)

A compatible, biodegradable microcapsule delivery system for active ingredients, including hormonally active peptides, proteins, or other bioactive molecules, and a method of making the same. The ingredients are encapsulated in biodegradable copolymer excipients of varying mole ratios and the blend ...


4
Thomas R Tice, Danny H Lewis, Donald R Cowsar, Lee R Beck: Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents. The Stolle Research and Development Corporation, Southern Research Institute, Oblon Fisher Spivak McClelland & Maier, July 23, 1985: US04530840 (247 worldwide citation)

An anti-inflammatory agent containing microparticle composition prepared by a process, comprising (a) dissolving or dispersing an anti-inflammatory agent in a solvent and dissolving a biocompatible and biodegradable wall forming material in said solvent; (b) dispersing said solvent containing said a ...


5
Thomas R Tice, Richard M Gilley, John H Eldridge, Jay K Staas, Melinda G Hollingshead, William M Shannon: Method of potentiating an immune response. Southern Research Institute, UAB Research Foundation, Needle & Rosenberg, December 24, 1991: US05075109 (232 worldwide citation)

A method of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size ranging from between approximately one micrometer to approximately ten micrometers and admnistering effective amo ...


6
Thomas R Tice, Richard M Gilley: Microencapsulation process and products therefrom. Southern Research Institute, Needle & Rosenberg, April 18, 1995: US05407609 (193 worldwide citation)

A method of microencapsulating an agent to form a microencapsulated product, having the steps of dispersing an effective amount of the agent in a solvent containing a dissolved wall forming material to form a dispersion, combining the dispersion with an effective amount of a continuous process mediu ...


7
Jean A Setterstrom, John E Van Hamont, Robert H Reid, Elliot Jacob, Ramasubbu Jeyanthi, Edgar C Boedeker, Charles E McQueen, Daniel L Jarboe, Frederick Cassels, William Brown, Curt Thies, Thomas R Tice, F Donald Roberts, Phil Friden: Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix. The United States of America represented by the Secretary of the Army, Caroline Nash, Elizabeth Arwine, October 30, 2001: US06309669 (178 worldwide citation)

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically ...


8
Robert N Boyes, Thomas R Tice, Richard M Gilley, Kenneth L Pledger: Pharmaceutical formulations comprising microcapsules. Innovata Biomed, Harness Dickey & Pierce, January 24, 1995: US05384133 (148 worldwide citation)

Pharmaceutical formulations comprise (i) microcapsules which consist essentially of a biocompatible polymeric wall material encapsulating a drug, and (ii) a lipid soluble surfactant which is mixed with the microcapsules or is incorporated within or coats the wall material of the microcapsules. Such ...


9
Thomas R Tice, William E Meyers, Richard M Gilley, William M Shannon: Long-acting biocidal compositions and method therefor. Southern Research Institute, Hopgood Calimafde Kalil Blaustein & Judlowe, April 29, 1986: US04585482 (120 worldwide citation)

There is disclosed, in one aspect, a long-acting biocidal composition. This composition comprises a chlorine dioxide-liberating compound, such as sodium chlorite, and sufficient organic acid-generating compound, such as poly(lactic acid), to lower the pH of the composition to less than about 7. The ...


10
Thomas R Tice, Danny H Lewis, Donald R Cowsar, Lee R Beck: Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents. The Stolle Research and Development Corporation, Southern Research Institute, Oblon Fisher Spivak McClelland & Maier, September 17, 1985: US04542025 (117 worldwide citation)

An anti-inflammatory agent containing microparticle composition prepared by a process, comprising (a) dissolving or dispersing an anti-inflammatory agent in a solvent and dissolving a biocompatible and biodegradable wall forming material in said solvent; (b) dispersing said solvent containing said a ...



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