1
Edward E Fitchard, Gustavo H Olivera, Paul J Reckwerdt, Thomas R Mackie: Delivery modification system for radiation therapy. Wisconsin Alumni Research Foundation, Quarles & Brady, May 7, 2002: US06385286 (211 worldwide citation)

Radiotherapy controlling, treatment sinograms may be directly modified to correct for real time motion of patients or portions of patients resulting from physiological or other activity. Precalculated partial sinograms representing treatments of portions of a patient may be assembled to obtain a tre ...


2
Joseph O Deasy, Thomas R Mackie, Paul M DeLuca Jr: Method and apparatus for proton therapy. Wisconsin Alumni Research Foundation, Quarles & Brady, September 16, 1997: US05668371 (192 worldwide citation)

A method of proton tomotherapy provides uniform dose placement within a tumorous area on a slice by slice basis by locating a Bragg peak of the proton beam at the distal edge of the tumor and irradiating the tumor from a number of different angles without sweeping the range of the protons at the giv ...


3
Thomas R Mackie, Paul J Reckwerdt, Todd R McNutt: Method and apparatus for calibration of radiation therapy equipment and verification of radiation treatment. Wisconsin Alumni Research Foundation, Quarles & Brady, February 5, 2002: US06345114 (130 worldwide citation)

A method of calibration and verification of radiotherapy systems deduced radiation beam fluence profiles from the radiation source from a complete model of an extended radiation phantom together with dose information from a portal imaging device. The improved beam fluence profile characterization ma ...


4
David M Shepard, Peter Hoban, Thomas R Mackie, Paul J Reckwerdt, Gustavo H Olivera: Method for preparing a radiation therapy plan. Wisconsin Alumni Research Foundation, Quarles & Brady, May 6, 2003: US06560311 (116 worldwide citation)

A method for determining a radiation treatment plan for a radiotherapy system providing multiple individual rays of intensity modulated radiation iteratively optimized the fluence of an initial set of such rays by a function that requires knowledge of only the prescribed dose and the dose resulting ...


5
Jeffrey M Kapatoes, Gustavo H Olivera, Paul J Reckwerdt, Thomas R Mackie, Kenneth J Ruchala: Fluence adjustment for improving delivery to voxels without reoptimization. TomoTherapy Incorporated, William K Baxter, Godfrey & Kahn S C, December 9, 2003: US06661870 (109 worldwide citation)

A method of compensating for unexpected changes in the size, shape, and/or position of a patient in the delivery of radiation therapy. An image of a patient is used to prepare a treatment plan for the irradiation of a tumor or the like, shown in the image. A second image of a patient includes a visu ...


6
Stuart Swerdloff, Thomas R Mackie, Timothy Holmes: Verification system for radiation therapy. Wisconsin Alumni Research Foundation, Quarles & Brady, February 28, 1995: US05394452 (103 worldwide citation)

A radiation therapy apparatus includes a compensator with moving leaves to attenuate a radiation beam and a compensator verification system to determine if the attenuating leaves are moving in accordance with desired position signals. Two radiation intensity monitoring chambers, one chamber on eithe ...


7
Paul J Reckwerdt, Thomas R Mackie: Method of registering a radiation treatment plan to a patient. Wisconsin Alumni Research Foundation, Quarles & Brady, September 30, 1997: US05673300 (98 worldwide citation)

A method for aligning a patient for radiation treatment based on an earlier tomographic scan of the patient uses projection images used to reconstruct a tomographic image rather than reconstructed images and compares the projection images directly to projection images taken at the time of the radiat ...


8
Stuart Swerdloff, Thomas R Mackie, Timothy Holmes, Paul J Reckwerdt: Dynamic collimator for radiation therapy. Wisconsin Alumni Research Foundation, Quarles & Brady, August 15, 1995: US05442675 (93 worldwide citation)

A radiation therapy apparatus includes a collimator that changes the width of a fan beam of radiation as a treatment volume of the patient crosses the volume exposed by the beam so as to minimize the irradiation of healthy tissue at the front and back of the tumor. The width of the fan beam may also ...


9
Stuart Swerdloff, Thomas R Mackie, Timothy Holmes: Method and apparatus for radiation therapy. Wisconsin Alumni Research Foundation, Quarles & Brady, May 31, 1994: US05317616 (80 worldwide citation)

A radiation therapy apparatus includes a compensator having a plurality of leaves to divide the radiation beam into rays each of which may be effectively and individually attenuated over a range of attenuations by controlling the duty cycle of the leaves position between the open and closed states. ...


10
Gustavo H Olivera, Jeffrey M Kapatoes, Thomas R Mackie, Paul J Reckwerdt, Edward E Fitchard, Julie C Zachman: Method using post-patient radiation monitor to verify entrance radiation and dose in a radiation therapy machine. Wisconsin Alumni Research Foundation, Quarles & Brady, August 20, 2002: US06438202 (75 worldwide citation)

In radiotherapy, a high quality imaging array may be placed after the patient and opposite the radiation source to be used during radiation treatment to verify operation of a shutter system or similar device and/or to compute dose delivered to the patient. A model of the patient may be used and inve ...