1
Thomas P Hedman, John P Kostuik, Geoffrey R Fernie, Brian E Maki: Artificial spinal disc. Health & Research Services, Rogers Bereskin & Parr, July 26, 1988: US04759769 (827 worldwide citation)

An artificial disc for a human spine. The disc has upper and lower members hinged together at their rear portions and biased apart at their fronts by stiff coil springs. Rear stop surfaces limit the opening movement of the members. Vertically projecting tabs at the front and side of each member are ...


2
Paul Slusarewicz, Thomas P Hedman: Formulations for nonsurgical exogenous crosslink therapy. Orthopeutics, Berliner & Associates, October 9, 2012: US08283322 (7 worldwide citation)

Improved methods and compositions for the treatment of native tissues with crosslinkers are provided. The methods and compositions will find particular use in increasing resistance to tearing, fissuring, rupturing, and/or delamination.


3
Thomas P Hedman: Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability. University of Southern California, Hogan & Hartson, October 14, 2008: US07435722 (7 worldwide citation)

A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous tissue with an effective amount of a crosslinking reagent. Methods and devices for enhancing the body's o ...


4
Thomas P Hedman, Paul Slusarewicz: Direct application of non-toxic crosslinking reagents to resist progressive spinal degeneration and deformity. Orthopeutics, Berliner & Associates, February 21, 2012: US08119599 (5 worldwide citation)

A method of treatment of native, non-denatured tissue to increase resistance to tearing, fissuring, rupturing, and/or delamination, comprising the step of: contacting at least a portion of the tissue with an effective amount of a reagent that increases crosslinks in the tissue.


5
Thomas P Hedman, Paul Slusarewicz: Formulations for nonsurgical exogenous crosslink therapy. Orthopeutics, Berliner & Associates, June 12, 2012: US08198248 (5 worldwide citation)

Improved methods and compositions for the treatment of native tissues with crosslinkers are provided. The methods and compositions will find particular use in increasing resistance to tearing, fissuring, rupturing, and/or delamination.


6
Thomas P Hedman: Method of treating a knee meniscus with a cross-linking reagent to increase resistance to tearing or rupturing. Orthopeutics, Berliner & Associates, September 20, 2011: US08022101 (4 worldwide citation)

A method of treatment of native, non-denatured tissue to increase resistance to tearing, fissuring, rupturing, and/or delamination, comprising the step of: contacting at least a portion of the tissue with an effective amount of a reagent that increases crosslinks in the tissue.


7
Thomas P Hedman: Direct application of non-toxic crosslinking reagents to resist progressive spinal degeneration and deformity. Orthopeutics, Berliner & Associates, July 3, 2012: US08211938 (4 worldwide citation)

A method of treatment of native, non-denatured tissue to increase resistance to tearing, fissuring, rupturing, and/or delamination, comprising the step of: contacting at least a portion of the tissue with an effective amount of a reagent that increases crosslinks in the tissue.


8
Thomas P Hedman: Direct application of non-toxic crosslinking reagents to resist progressive spinal deformity. Orthopeutics, Berliner & Associates, April 10, 2012: US08153600 (3 worldwide citation)

A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous tissue with an effective amount of a crosslinking reagent. Methods and devices for enhancing the body's o ...


9
Thomas P Hedman: Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability. Orthopeutics, Berliner & Associates, May 28, 2013: US08450276 (2 worldwide citation)

A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous tissue with an effective amount of a crosslinking reagent. Methods and devices for enhancing the body's o ...


10
Thomas P Hedman, Pawel Slusarewicz: Tissue crosslinking for treatment of snoring and obstructive sleep apnea. Orthopeutics, Berliner & Associates, November 24, 2015: US09192507 (2 worldwide citation)

A method of treating snoring and/or OSA in a subject in need of such treatment. The method includes crosslinking proteins of the subject's soft palate tissue or pharynx tissue. The crosslinking can occur by contacting the soft palate or pharynx tissue with a crosslinking reagent. In addition, the cr ...