1
Willson H Burgess, Howard P Greisler, William N Drohan, Thomas Maciag, Martin J MacPhee: Method of preparing a tissue sealant-treated biomedical material. Loyola University of Chicago, The American National Red Cross, Sterne Kessler Goldstein & Fox P L L C, May 6, 2003: US06559119 (84 worldwide citation)

This invention provides methods for the preparation of a tissue sealant-treated biomaterial, wherein the tissue sealant used in the method comprises at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial composit ...


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William N Drohan, Martin J MacPhee, Hernan Nunez, Gene Liau, Thomas Maciag, Wilson H Burgess: Methods for treating wound tissue and forming a supplemented fibrin matrix. The American National Red Cross, Sterne Kessler Goldstein & Fox P L L C, March 27, 2007: US07196054 (37 worldwide citation)

This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antimicrobial composition. The composition may be further supplemented with, for example, one or more antibodi ...


4
Gregory M Fahy, Bijan Khirabadi, Yasumitsu Okouchi, Thomas Maciag: Method of preparing organs for vitrification. The American National Red Cross, Oliff & Berridge, March 3, 1998: US05723282 (37 worldwide citation)

The invention relates to the field of organ and tissue perfusion. More particularly, the present invention relates to a method for preparing organs, such as the kidney and liver, for cryopreservation through the introduction of vitrifiable concentrations of cryoprotectant into them. To prepare the o ...


5
William N Drohan, Martin J MacPhee, Wilson H Burgess, Hernan Nunez, Manish Singh, Gene Liau, Thomas Maciag: Supplemented and unsupplemented tissue sealants, methods of their production and use. The American National Red Cross, Stern Kessler Goldstein & Fox P L L C, March 13, 2007: US07189410 (33 worldwide citation)

This invention provides a fibrin sealant bandage, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiproliferatives, anti-inflammatory compou ...


6
Thomas Maciag, Ann B Zimrin, Deena J Small, Igor A Prudovsky: Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids. Maine Medical Center Research Institute, Morgan Lewis & Bockius, April 6, 2004: US06716974 (28 worldwide citation)

This invention relates to therapeutic and diagnostic methods and compositions based on Jagged/Notch proteins and nucleic acids, and on their role in the signaling pathway relating to endothelial cell migration and/or differentiation. In addition, this invention provides a substantially purified Jagg ...


7
William N Drohan, Martin J MacPhee, Hernan Nunez, Gene Liau, Wilson H Burgess, Thomas Maciag: Supplemented fibrin matrix delivery systems. The American National Red Cross, Sterne Kessler Goldstein & Fox P L L C, June 12, 2007: US07229959 (27 worldwide citation)

This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antibody. The composition may be further supplemented with, for example, one or more analgesics, antimicrobial ...


8
Michael Jaye, Wilson Burgess, Thomas Maciag, William Drohan: Recombinant DNA vector encoding human endothelial cell growth factor. Rorer Biotechnology, September 19, 1989: US04868113 (26 worldwide citation)

Endothelial cell growth factor is achieved through the application of recombinant DNA technology to prepare cloning vehicles encoding the ECGF protein and procedures are disclosed for recovering ECGF protein essentially free of other proteins of human origin. The product is useful for, among other p ...


9
Ann B Zimrin, Michael Wong, Thomas Maciag, Michael S Pepper, Roberto Montesano: Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids. Maine Medical Center Research Institute, Morgan Lewis & Bockius, August 13, 2002: US06433138 (21 worldwide citation)

This invention relates to therapeutic and diagnostic methods and compositions based on Jagged/Notch proteins and nucleic acids, and on the role of their signaling pathway in endothelial cell migration and/or differentiation. In addition, this invention provides a substantially purified Jagged protei ...


10
Gregory M Fahy, Bijan Khirabadi, Yasumitsu Okouchi, Thomas Maciag: Method for preparing organs for transplantation after cryopreservation. The American National Red Cross, Oliff & Berridge, February 13, 2001: US06187529 (13 worldwide citation)

The invention relates to the field of organ and tissue perfusion. More particularly, the present invention relates to a method for preparing organs, such as the kidney and liver, for cryopreservation through the introduction of vitrifiable concentrations of cryoprotectant into them. To prepare the o ...