1
Thomas M Brennan: Method and apparatus for conducting an array of chemical reactions on a support surface. ProtoGene Laboratories, Banner & Allegretti, December 12, 1995: US05474796 (636 worldwide citation)

The invention provides apparatus and methods for making arrays of functionalized binding sites on a support surface. The invention further provides apparatus and methods for sequencing oligonucleotides and for identifying the amino acid sequence of peptides that bind to biologically active macromole ...


2
Thomas M Brennan: Apparatus and method for polymer synthesis using arrays. The Board of Trustees of the Leland Stanford Junior University, Flehr Hohbach Test Albritton & Herbert, December 5, 1995: US05472672 (127 worldwide citation)

A polymer synthesis apparatus (20) for building a polymer chain including a head assembly (21) having an array of nozzles (22) with each nozzle coupled to a reservoir (23) of liquid reagent (24) , and a base assembly (25) having an array of reaction wells (26). A transport mechanism (27) aligns the ...


3
Thomas M Brennan: Apparatus and method for polymer synthesis using arrays. The Board of Trustees of The Leland Stanford Junior University, Flehr Hohbach Test Albritton & Herbert, June 25, 1996: US05529756 (118 worldwide citation)

A polymer synthesis apparatus (20) for building a polymer chain including a head assembly (21) having an array of nozzles (22) with each nozzle coupled to a reservoir (23) of liquid reagent (24), and a base assembly (25) having an array of reaction wells (26). A transport mechanism (27) aligns the r ...


4
Thomas M Brennan, Herbert L Heyneker: Methods and compositions for determining the sequence of nucleic acids. Richard F Trecartin, April 4, 1995: US05403708 (117 worldwide citation)

Methods and compositions for forming ligation product hybridized to a nucleic acid template. The ligation product is formed by contacting a nucleic acid template with a primer capable of hybridizing to the template to form a primed template. The primed template is then contacted with a pool of rando ...


5
Thomas M Brennan: Apparatus for diverse chemical synthesis using two-dimensional array. Protogene Laboratories, Flehr Hohbach Test Albritton & Herbert, December 14, 1999: US06001311 (108 worldwide citation)

A chemical synthesis apparatus (20) for building chemical compounds includes a head assembly (21) having an array of nozzles (22) with each nozzle or plurality of nozzles coupled to a reservoir (23) of liquid reagent (24), and a base assembly (25) having an array of reaction wells (26). A transport ...


6
Thomas M Brennan: Apparatus for determining DNA sequences by mass spectrometry. Genomyx, Allegretti & Witcoff, December 29, 1992: US05174962 (80 worldwide citation)

This invention relates to the apparatus, for sequencing natural or recombinant DNA and other polynucleotides. In particular, this invention relates to a method for sequencing polynucleotides based on mass spectrometry to determine which of the four bases (adenine, guanine, cytosine or thymine) is a ...


7
Thomas M Brennan: Determining DNA sequences by mass spectrometry. Genomyx, Allegretti & Witcoff, March 26, 1991: US05003059 (78 worldwide citation)

This invention relates to the methods, apparatus, reagents and mixtures of reagents for sequencing natural or recombinant DNA and other polynucleotides. In particular, this invention relates to a method for sequencing polynucleotides based on mass spectrometry to determine which of the four bases (a ...


8
Thomas M Brennan, Burrell E Hammons, David R Myers, Gregory A Vawter: Ion-implanted planar-buried-heterostructure diode laser. The United States of America represented by the United States Department of Energy, Karla Ojanen, James H Chafin, William R Moser, September 10, 1991: US05048038 (67 worldwide citation)

A Planar-Buried-Heterostructure, Graded-Index, Separate-Confinement-Heterostructure semiconductor diode laser 10 includes a single quantum well or multi-quantum well active stripe 12 disposed between a p-type compositionally graded Group III-V cladding layer 14 and an n-type compositionally graded G ...


9
Thomas M Brennan: Method and apparatus for conducting an array of chemical reactions on a support surface. Protogene Laboratories, Albert P Halluin, John A Howrey & Simon Bendrick, November 16, 1999: US05985551 (63 worldwide citation)

The invention provides apparatus and methods for making arrays of functionalized binding sites on a support surface. The invention further provides apparatus and methods for sequencing oligonucleotides and for identifying the amino acid sequence of peptides that bind to biologically active macromole ...


10
Thomas M Brennan: Method and apparatus for conducting an array of chemical reactions on a support surface. Protogene Laboratories, Albert P Halluin, Wallace Wu, Howrey Simon Arnold & White, April 3, 2001: US06210894 (60 worldwide citation)

The invention provides apparatus and methods for making arrays of functionalized binding sites on a support surface. The invention further provides apparatus and methods for sequencing oligonucleotides and for identifying the amino acid sequence of peptides that bind to biologically active macromole ...



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