1
Thomas L Smestad, John McPherson, Donald G Wallace: Injectable cross-linked collagen implant material. Collagen Corporation, Ciotti & Murashige, April 15, 1986: US04582640 (271 worldwide citation)

Cross-linked atelopeptide collagen that is substantially free of residual cross-linking agent is prepared by: reconstituting atelopeptide collagen from solution by neutralizing the solution at a reduced temperature and a hypotonic ionic strength; cross-linking the reconstituted fibers in an aqueous ...


2
Karl A Piez, Bruce B Pharriss, George H Chu, Thomas L Smestad, Diana Hendricks: Xenogeneic collagen/mineral preparations in bone repair. Collagen Corporation, Ciotti & Murashige Irell & Manella, January 3, 1989: US04795467 (182 worldwide citation)

A composition for use in bone repair, in particular, in onlay procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new ...


3
Donald G Wallace, Thomas L Smestad, John M McPherson, Karl A Piez, Saeid Seyedin, Rosa Armstrong: Methods of bone repair using collagen. Collagen Corporation, Ciotti & Murashige Irell & Manella, December 6, 1988: US04789663 (175 worldwide citation)

A method of repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or mixtures thereof is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen may also be ly ...


4
Thomas L Smestad: Nonstress-bearing implantable bone prosthesis. Collagen Corporation, Ciotti & Murashige, February 14, 1984: US04430760 (146 worldwide citation)

A flexible, nonstress-bearing bone prosthesis is disclosed that comprises demineralized bone powder contained within a medical grade porous flexible casing made from polymeric fibers or a micro-porous membrane. The pores of the casing are smaller than the particle size of the bone powder but large e ...


5
Woonza M Rhee, Richard A Berg, Joel S Rosenblatt, Jacqueline A Tefft, Larry J Braga, Thomas L Smestad: Method of preparing crosslinked biomaterial compositions for use in tissue augmentation. Collagen Corporation, Kathi Rafayko, August 27, 1996: US05550187 (138 worldwide citation)

The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is prefer ...


6
Woonza M Rhee, Richard A Berg, Joel S Rosenblatt, Jacqueline A Schroeder, Larry J Braga, Thomas L Smestad, Abigail Freeman: Process for preparing a sterile, dry crosslinking agent. Collagen Corporation, Kathi Rafayko, July 1, 1997: US05643464 (118 worldwide citation)

The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is prefer ...


7
Karl A Piez, Bruce B Pharriss, George H Chu, Thomas L Smestad, Diana Hendricks: Calcium phosphate/atelopeptide collagen compositions for bone repair. Collagen Corporation, Morrison & Foerster, June 20, 1995: US05425770 (66 worldwide citation)

Processes for the preparation of compositions used in conductive bone repair are disclosed. The compositions contain a mixture consisting essentially of either a calcium phosphate particulate mineral component or particulate hydroxyapatite in admixture with atelopeptide reconstituted fibrillar colla ...


8
Thomas L Smestad, Daniel Prows, George H Chu, Diana M Hendricks: Gamma irradiation of collagen/mineral mixtures. Collagen Corporation, Irell & Manella, September 12, 1989: US04865602 (63 worldwide citation)

A process for sterilization of collagen/mineral compositions using .gamma. radiation is conducted under conditions which produce a product of desired handling and biocompatibility properties.


9
Thomas L Smestad, Daniel Prows, George H Chu, Diana M Hendericks, Debera Brown: Gamma irradiation of collagen/mineral mixtures. Collagen Corporation, Morrison & Foerster, June 23, 1992: US05123925 (59 worldwide citation)

The present invention is a method for treating bony defects. The method involves contacting the bony defect with a formable composition and allowing the formable composition to solidify. The formable composition is comprised of 2-40% of reconstituted fibrillar atelopeptide collagen and 60-98% calciu ...


10
Ann Brannan, Roseann Burhenne, Frank A Delustro, Thomas L Smestad, Louis Fries, Rees M Orland: Device for treating fine superficial facial lines. Collagen Corporation, Morrison & Foerster, November 22, 1994: US05366498 (59 worldwide citation)

A device for correcting fine superficial facial lines which comprises a syringe fitted with a 31-33 gauge needle and an aqueous suspension of noncrosslinked fibrillar atelopeptide collagen contained within the syringe barrel, the concentration of collagen in the suspension being in the range of 10 t ...



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