1
Sébastien François Emmanuel Lemaire, Andras Horvath, Wim Albert Alex Aelterman, Thomas Joachim Landewald Rammeloo: Methods for the preparation of hexahydrofuro[2,3-B]furan-3-ol. Janssen Pharmaceutica, Woodcock Washburn, April 10, 2012: US08153829

Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol and especially its enantiomer (3R,3aS,6aR) hexahydrofuro[2,3-b]furan-3-ol, as well as certain novel intermediates for use in such methods are disclosed.


2
Sébastien François Emmanuel Lemaire, Andras Horvath, Wim Albert Alex Aelterman, Thomas Joachim Landewald Rammeloo: METHODS FOR THE PREPARATION OF HEXAHYDROFURO[2,3-b]FURAN-3-OL. Tibotec Pharmaceuticals, Philip S Johnson, Johnson & Johnson, April 15, 2010: US20100094028-A1

Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol and especially its enantiomer (3R,3aS,6aR) hexahydrofuro[2,3-b]furan-3-ol, as well as certain novel intermediates for use in such methods.


3
Thomas Joachim Landewald Rammeloo, Ruben De Keyser, Gustaaf Jozef Petrus Schildermans: Crystallisation process for 1-(beta-d-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl] benzene. May 3, 2012: US20120108824-A1

The present invention relates to a crystallisation procedure to obtain 1-(β-D- glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl] benzene hemihydrate crystals having a narrow particle size distribution and improved flowability, bulk and tap density properties.



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