1
Daphne Winifred Bell, Daniel A Haber, Pasi Antero Janne, Bruce E Johnson, Thomas J Lynch, Matthew Meyerson, Juan Guillermo Paez, William R Sellers, Jeffrey E Settleman, Raffaella Sordella: Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments. The General Hospital Corporation, Dana Farber Cancer Institute, Nixon Peabody, November 13, 2007: US07294468 (63 worldwide citation)

The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhib ...


2
William L Hergenrother, Thomas J Lynch: Amine-initiated elastomers having hysteresis reducing interaction with silica. Bridgestone Corporation, Daniel N Hall, June 29, 1999: US05916961 (46 worldwide citation)

The reduction of hysteresis in a silica-filled, vulcanized elastomeric compound is produced by mixing diene monomer and optionally monovinyl aromatic monomer with a lithium amine initiator and, optionally, a modifier; effecting polymerization conditions; terminating polymerization with an amino grou ...


3
Robert W Hill, William L Kehl, Thomas J Lynch: Ethylene polymerization catalysts. Gulf Oil Corporation, Richard L Kelly, August 26, 1980: US04219444 (39 worldwide citation)

Novel catalysts are provided for the polymerization of olefins such as ethylene. The catalysts consist essentially of a chromium compound supported upon an inorganic carrier containing aluminum and phosphorus moieties, at least a portion of the chromium having a valence of less than 6. The inorganic ...


4
David F Lawson, Hideo Takeichi, William L Hergenrother, Thomas J Lynch, James Oziomek: Composition of cyclic amine-initiated elastomers and amorphous silica and process for the production thereof. Bridgestone Corporation, D A Thomas, February 2, 1999: US05866650 (38 worldwide citation)

The reduction of hysteresis in a silica-filled, vulcanized elastomeric compound is produced by mixing diene monomer and optionally monovinyl aromatic monomer with a lithium amine initiator and, optionally, a modifier; effecting polymerization conditions; terminating polymerization with an amino grou ...


5
William J Heilman, Thomas J Lynch: Mineral oil compositions having improved pour point containing alpha-olefin copolymers. Gulf Research & Development Company, January 2, 1979: US04132663 (38 worldwide citation)

Compounded mineral oil compositions having improved pour point are obtained by the incorporation therein of a minor amount of an alpha-olefin copolymer of 1-hexene and 1-octadecene.


6
Thomas J Lynch: Respiratory gas monitor. Temple University of the Commonwealth System of Higher Education, Seidel Gonda Lavorgna & Monaco, February 15, 1994: US05285794 (35 worldwide citation)

A method and apparatus for monitoring the respiratory gas of a patient includes an adjustable volume gas mixing chamber which allows for the differences in lung capacity of patients from neonate to adult. A constant flow of a therapeutic gas mixture is measured by a flow meter in a supply line leadi ...


7
Warren C Hillbish, Emad K Ibrahim, John W Kaufman, Thomas J Lynch: Method of manufacturing electrical connectors. AMP Incorporated, Katherine A Nelson, December 24, 1991: US05074039 (34 worldwide citation)

A method for manufacturing electrical connectors (22) which include rows of contact members (78, 90) held in a housing (24) includes feeding contact members in a wire form in parallel (74, 90), trimming such contact members to provide a partial form therefore at a trim station A, insert-molding such ...


8
Thomas J Lynch: Metal oxide aerogels. Gulf Research & Development Company, Richard L Kelly, August 31, 1976: US03977993 (24 worldwide citation)

Novel metal oxide aerogels, particularly silica aerogels, having a combination of both a large surface area and a large pore volume are provided. Such aerogels have a surface area of at least 300 square meters per gram and a pore volume of at least 2 milliliters per gram, said values being determine ...


9
William J Heilman, Thomas J Lynch: Process for preparing a concentrate of a polyalpha-olefin in a lubricating oil base stock. Gulf Research & Development Company, June 22, 1976: US03965018 (20 worldwide citation)

A process for preparing a concentrate of a polyalpha-olefin in a hydrotreated lubricating oil base stock by conditioning the base stock in the presence of hydrogen and a Ziegler-Natta type catalyst and then polymerizing an alpha-olefin in the conditioned, hydrotreated lubricating oil base stock as t ...


10
Daphne Winifred Bell, Daniel A Haber, Pasi Antero Janne, Bruce E Johnston, Thomas J Lynch, Matthew Meyerson, Juan Guillermo Paez, William R Sellers, Jeffrey E Settleman, Raffaella Sordella: Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments. The General Hospital Corporation, Dana Farber Cancer Institute, Nixon Peabody, June 21, 2011: US07964349 (20 worldwide citation)

The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhib ...