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Robert Steven Kania, Steven Lee Bender, Allen J Borchardt, Stephan James Cripps, Ye Hua, Michael David Johnson, Theodore Otto Johnson Jr, Hiep The Luu, Cynthia Louise Palmer, Siegfried Heinz Reich, Anna Marie Tempczyk Russell, Min Teng, Christine Thomas, Michael David Varney, Michael Brennan Wallace, Michael Raymond Collins: Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use. Agouron Pharmaceuticals, March 18, 2003: US06534524 (85 worldwide citation)

Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The inv ...


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Robert Steven Kania, Steven Lee Bender, Allen J Borchardt, Stephan James Cripps, Ye Hua, Michael David Johnson, Theodore Otto Johnson Jr, Hiep The Luu, Cynthia Louise Palmer, Siegfried Heinz Reich, Anna Marie Tempczyk Russell, Min Teng, Christine Thomas, Michael David Varney, Michael Brennan Wallace, Michael Raymond Collins: Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use. Agouron Pharmaceuticals, Stephen D Prodnuk, Bryan C Zielinski, Peter C Richardson, April 26, 2005: US06884890 (38 worldwide citation)

Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The inv ...


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Roland Ellwood Dolle III, Tao Guo, Theodore Otto Johnson Jr, Hitesh K Patel, Shiwei Tao, Zhen Min He: Combinatorial hydroxy-amino acid amide libraries. Pharmacopeia, Heslin & Rothenberg P C, October 26, 1999: US05972719 (15 worldwide citation)

Combinatorial chemical libraries of Formula I ##STR1## and methods for their preparation are disclosed. The libraries allow one to screen large numbers of compounds for a desired biological activity with relative ease. The libraries may be tagged or untagged. In preferred libraries, Y is the residue ...


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Robert Steven Kania, Steven Lee Bender, Allen J Borchardt, Stephan James Cripps, Ye Hua, Michael David Johnson, Theodore Otto Johnson Jr, Hiep The Luu, Cynthia Louise Palmer, Siegfried Heinz Reich, Anna Maria Tempczyk Russell, Min Teng, Christine Thomas, Michael David Varney, Michael Brennan Wallace, Michael Raymond Collins: Indazole compounds and pharmaceutical compositions for Inhibiting protein kinases, and methods for their use. Agouron Pharmaceuticals, Peter C Richardson, Bryan C Zielinski, Edward D Robinson, May 10, 2005: US06891044 (4 worldwide citation)

Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The inv ...


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Robert Steven Kania, Steven Lee Bender, Allen J Borchardt, Stephan James Cripps, Ye Hua, Michael David Johnson, Theodore Otto Johnson Jr, Hiep The Luu, Cynthia Louise Palmer, Siegfried Heinz Reich, Anna Maria Tempczyk Russell, Min Teng, Christine Thomas, Michael David Varney, Michael Brennan Wallace, Michael Raymond Collins: Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use. Agouron Pharmaceuticals, Edward D Robinson, Bryan C Zielinski, November 28, 2006: US07141587 (4 worldwide citation)

Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The inv ...


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Hengmiao Cheng, Theodore Otto Johnson Jr, John Charles Kath, Kevin Kun Chin Liu, Elizabeth Ann Lunney, Asako Nagata, Sajiv Krishnan Nair, Simon Paul Planken, Scott Channing Sutton: Pyrrolopyrimidine and purine derivatives. Pfizer, Suzanne M Bates, Stephen D Prodnuk, May 26, 2015: US09040547 (3 worldwide citation)

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, T, V, W, X, Y, Z, ring A, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17 and m are defined herein. There novel pyrrolopyrimidine and purine derivatives ...


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Douglas Carl Behenna, Hengmiao Cheng, Sujin Cho Schultz, Theodore Otto Johnson Jr, John Charles Kath, Asako Nagata, Sajiv Krishnan Nair, Simon Paul Planken: Purine derivatives. Pfizer, Suzanne M Bates, Stephen D Prodnuk, March 22, 2016: US09290496

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, G, ring A, ring B, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, and m are defined herein. The novel purine derivat ...


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