1
Kimio Mizuno, Tetsuo Matsuda, Katsumi Asano, Akira Yagi, Masaki Takada, Tetsu Saito, Minoru Toriya, Shuzo Satoi, Kazuo Matsuura: Antibiotic aculeacins. Toyo Jozo Kabushiki Kaisha, Young & Thompson, August 31, 1976: US03978210 (39 worldwide citation)

A family of antibiotics active against pathogenic yeasts and fungi comprises aculeacin-A, -B, -C, -D, -E, -F, and -G. These are produced from cultured broth of Aspergillus aculeatus FERM-P 2324.


2
Masaru Otani, Tetsu Saito, Shuzo Satoi, Junzo Mizoguchi, Naoki Muto: Amino sugar compound. Toyo Jozo company, Craig & Antonelli, March 3, 1981: US04254256 (18 worldwide citation)

An amino sugar compound represented by the general formula: ##STR1## (wherein m is an integer of 0 to 8, n is an integer of 1 to 8 and m+n is an integer of 1 to 8) has strong glycosidase inhibiting action and is produced by culturing an amino sugar compound producing microorganisms belonging to Stre ...


3
Sadaaki Iwanaga, Shunichiro Kawabata, Tetsu Saito: Lipopolysaccharide binding protein and process for producing the same. Seikagaku Kogyo Kabushiki Kaisha, Testa Hurwitz & Thibeault, June 2, 1998: US05760177 (14 worldwide citation)

The invention provides a lipopolysaccharide (LPS) binding protein isolated from horseshoe crab. The LPS binding protein is isolated by (i) extracting the hemocyte membrane fraction of horseshoe crab with a polyethylene glycol ether type nonionic surface active agent in the presence of Ca ions, (ii) ...


4
Masaru Otani, Satoshi Yaginuma, Masatoshi Tsujino, Naoki Muto, Tetsu Saito, Tadashiro Fujii: Neplanocin-B and -F. Toyo Jozo Kabushiki Kaisha, Young & Thompson, March 23, 1982: US04321376 (13 worldwide citation)

Neplanocin-B and -F of the formula ##STR1## in which Y is oxygen or a valence bond, are produced by culturing Ampullariella sp. A 11079 FERM-P No. 4494 in a nutrient medium and then separating the neplanocin-B and -F thus produced from the culture medium.


5
Satoshi Yaginuma, Atsuki Morishita, Naoki Muto, Kenya Ishizawa, Mitsuo Hayashi, Tetsu Saito: Antibiotic L53-18A and process for preparation thereof. Toyo Yozo Company, Darby & Darby, January 14, 1992: US05081023 (11 worldwide citation)

A antibiotic L53-18A and a pharmaceutically acceptable salt thereof which are useful for treatment of bacterial inventions are obtained by culturing, for example, Saccharopolyspora sp. L53-18 (FERM BP 2231) in a medium and the antibiotic accumulated therein is collected.


6
Yukio Suzuki, Masao Yaso, Katumi Nisimura, Kenzi Saeki, Noriyasu Takayanagi, Tetsu Saito, Eiichi Hayashi: 6-substituted alkoxy-2-oxo-1,2-dihydroquinoxaline derivatives. Toyo Jozo Kabushiki Kaisha, Young & Thompson, September 26, 1989: US04870175 (10 worldwide citation)

A compound of the formula ##STR1## wherein Z is N or NH, is a single or double bond, R.sub.1 is hydrogen, C.sub.1-20 alkyl or optionally substituted phenyl, A is lower alkylene, R is carboxyl, lower alkoxycarbonyl, ##STR2## or 1-cycloalkyl-tetrazole-5-yl, R.sub.2 is lower alkyl, hydroxy-lower alkyl ...


7
Mitsuyuki Matsumoto, Toru Sugimoto, Jun Takasaki, Masazumi Kamohara, Tetsu Saito, Masato Kobayashi: Polynucleotides encoding SRE B2 receptor. Yamanouchi Pharmaceutical, Sughrue Mion PLLC, April 29, 2003: US06555344 (7 worldwide citation)

This invention belongs to the genetic engineering field, and provides the novel G protein-coupled receptor family protein SREB2 expressed in the central nervous system, genes coding for the protein, screening methods using the protein and so on. As one of the methods for obtaining the G protein-coup ...


8
Masaru Otani, Satoshi Yaginuma, Masatoshi Tsujino, Naoki Muto, Tetsu Saito, Tadashiro Fujii: Antibiotic neplanocin A. Toyo Jozo Kabushiki Kaisha, Young & Thompson, December 27, 1983: US04423218 (6 worldwide citation)

Antibiotic neplanocin A of the formula ##STR1## is produced by culturing Ampullariella sp. A 11079 FERM-P No. 4494 in a nutrient medium and then separating the neplanocin A thus produced from the culture medium.


9
Masaru Otani, Shuzo Satoi, Naoki Muto, Tetsu Saito, Tadashiro Fujii, Seiji Katsumata, Mitsuo Hayashi, Masaru Ono: Novel macrolide antibiotics and preparation thereof. Toyo Jozo Company, Craig and Antonelli, September 22, 1981: US04291021 (3 worldwide citation)

A novel microorganism species belonging to the genus Micromonospora, i.e. Micromonospora sp. A 11725 is found to be capable of producing novel macrolide antibiotics A 11725 I, A 11725 II and A 11725 III. Novel antibiotics A 11725 Ia and A 11725 IIa are also found to be derived by chemical modificati ...


10
Sadaaki Iwanaga, Shun ichiro Kawabata, Tetsu Saito: Horseshoe crab hemocyte polypeptides, and preparation and DNA encoding thereof. Seikagaku Kogyo Kabushiki Kaisha, Testa Hurwitz & Thibeault, January 19, 1999: US05861378 (2 worldwide citation)

The present invention relates to polypeptide having a primary structure of amino acid sequence shown by Sequence List Sequence No. 1 and DNA encoding for the polypeptide. The polypeptide is obtainable by following steps (1)-(3):