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Evan C Unger, Terry O Matsunaga, David Yellowhair: Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles. ImaRx Pharmaceutical, Woodcock Washburn Kurtz Mackiewicz & Norris, March 31, 1998: US05733572 (255 worldwide citation)

Gas and gaseous precursor filled microspheres, and foams thereof, provide novel topical and subcutaneous delivery vehicles for various active ingredients, including drugs and cosmetics.


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Evan C Unger, Terry O Matsunaga, Patricia A Schumann: Targeted compositions for diagnostic and therapeutic use. ImaRx Therapeutics, DLA Piper, November 18, 2008: US07452551 (4 worldwide citation)

Novel targeted compositions which may be used for diagnostic and therapeutic use. The compositions may comprise lipid, protein or polymer gas-filled vesicles which further comprise novel compounds of the general formula L-P-T, wherein L comprises a hydrophobic compound, P comprises a hydrophilic pol ...


3
Paul A Dayton, Paul S Sheeran, Terry O Matsunaga, Mark A Borden: Formulation of acoustically activatable particles having low vaporization energy and methods for using same. The University of North Carolina at Chapel Hill, The Arizona Board of Regents on Behalf of The University of Arizona, The Regents of the University of Colorado, Jenkins Wilson Taylor & Hunt P A, August 30, 2016: US09427410

A method of producing particles of materials includes, with a first substance that includes at least one component that is a gas at room temperature and atmospheric pressure, extruding or emulsifying the first substance into or in the presence of a second substance to create a bubble in which the fi ...


4
Evan C Unger, Terry O Matsunaga, David Yellowhair: Container with multi-phase composition for use in diagnostic and therapeutic applications. Imarx Pharmaceutical, DING YEPING, August 27, 1997: CN95195094

A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.


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Evan C Unger, Reena Zutshi, Terry O Matsunaga: Non-invasive intravascular thrombolysis using modified ultrasound techniques. Gray Cary Ware & Freidenrich, December 30, 2004: US20040265393-A1

A non-invasive method for disrupting a blood clot within the vasculature of a patient using new ultrasound techniques is provided. Lipid vesicles containing a gas or gaseous precursor are administered intravascularly to the patient and ultrasound having a power greater than about 0.5 Watts/cm2 to ab ...


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Evan C Unger, Terry O Matsunaga, Reena Zutshi: Liquid-filled nanodroplets for anti-cancer therapy. Dla Piper Us, August 9, 2007: US20070184076-A1

A nanodroplet composition is provided, the nanodroplets include a lipid encapsulating a biologically compatible oil, a fluorocarbon composition including one or more fluorinated hydrocarbons, and a therapeutically active compound, where the fluorocarbon composition is in a liquid state at a temperat ...


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Evan C Unger, Rachel LaBell, Terry O Matsunaga, Reena Zutshi: Method To Administer Stem Cells In Combination With One Or More Acoustically Active Materials And Ultrasound Energy. Imarx Therapeutics, Dale F Regelman, August 21, 2008: US20080200862-A1

The invention comprises a method to administer stem cells to a patient in need thereof. The method provides acoustically active material, stem cells, and an ultrasound energy emitting device. The method administers the acoustically active material to the patient, administers the stem cells to the pa ...


8
Evan C Unger, Terry O Matsunaga, Reena Zutshi: Ultrasound Device and Method Using Same. ImaRx Therapeutics, Dale F Regelman, August 14, 2008: US20080194954-A1

An ultrasound energy emitting apparatus is disclosed. The ultrasound energy emitting apparatus comprises a hand-held enclosure and a plurality of ultrasound transducers disposed on that enclosure, or disposed within and extending outwardly from the enclosure. The plurality of ultrasound transducers ...


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