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Kiyoto Sumio, Nishikawa Motoaki, Iwami Morita, Terano Hiroshi, Kohsaka Masanobu, Imanaka Hiroshi: Biologically active ws 6049 substances, a process for the production thereof and their pharmaceutical compositions.. Fujisawa Pharmaceutical Co, November 30, 1983: EP0095154-A1 (64 worldwide citation)

Biologically active WS 6049 substances obtainable by culturing a strain belonging to the genus Actinomadura in an aqueous nutrient medium under aerobic conditions and recovering WS 6049-A substance and/or WS 6049-B substance. The invention also relates to a process for preparing the new substances a ...


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Terano Hiroshi, Tsurumi Yasuhisa, Setoi Hiroyuki, Hashimoto Masashi, Kohsaka Masanobu: Amino acid derivatives and processes for preparation thereof.. Fujisawa Pharmaceutical Co, September 10, 1986: EP0193904-A2 (2 worldwide citation)

A compound of the formula: wherein R is hydrogen, amino or a protected amino group, R is hydrogen, carboxy or a protected carboxy group, R is hydrogen, carboxy or a protected carboxy group, R is lower alkyl, amino(lower)alkyl, protected amino(lower)alkyl, carbamoyl(lower)alkyl or protected carbamoyl ...


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Shimojo Fumio Dai Wahigash, Sawai Seiji Yashiro Cho, Hori Sadao Minamiotsuka, Koseki Yoshiyuki Ikenoha, Terano Hiroshi Manabe, Okuhara Masakuni Umezono: Transocular preparation.. Fujisawa Pharmaceutical Co, August 3, 1994: EP0608419-A1 (1 worldwide citation)

A transocular preparation containing an oxaspirooctane derivative represented by general formula (I) or a salt thereof as an active ingredient and a pharmaceutically acceptable carrier, wherein R represents carbamoyl, etc., R represents lower alkoxy, etc., and R represents a group of formula (II), e ...


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Otsuka Takanao, Shibata Toshihiro, Terano Hiroshi, Tsurumi Yasuhisa, Okuhara Masakuni: New compound wf 2015 a and b, production thereof and use thereof.. Fujisawa Pharmaceutical Co, May 3, 1989: EP0314401-A2 (1 worldwide citation)

New compounds, designated WF 2015 A and B, are disclosed and which have the physicochemical characteristics described herein, are the following: (1) For WF 2015 A a) Molecular weight : 410 [FAB-MS : m/z 411 (M+H)] b) Elemental analysis : C 64.55; H 8.06; O 27.39 (by difference) c) Optical rotation: ...


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Nakajima Hidenori, Hori Yasuhiro, Goto Toshio, Takase Shigehiro, Verhaeghe Koen, Terano Hiroshi, Okuhara Masakuni: Substances wb2663, production thereof and use.. Fujisawa Pharmaceutical Co, April 13, 1994: EP0591534-A1

Substances WB2663A, WB2663B and WB2663C are produced by culturing a WB2663-producing bacterium belonging to the genus Pseudomonas to form physiologically active substances and isolating therefrom neutral substances respectively having the following specific rotation: [ alpha ] = -36 DEG (C =0.5 in C ...


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Hino Motohiro, Hori Yasuhiro, Hashimoto Masashi, Kohsaka Masanobu, Terano Hiroshi: Compose fr-900447, production et utilisation, Compound, fr-900447, production and use thereof. Fujisawa Pharmaceutical, SWABEY MITCHELL HOULE MARCOUX & SHER, July 5, 1988: CA1238874

ABSTRACT OF DISCLOSURE A new compound, FR-900447, and pharmaceutically acceptablesalts thereof has antimicrobial activity and antitumor activity. Aprocess for the preparation thereof comprises culturing a FR-900447producing strain belonging to the genus Streptomyces in a nutrientmedium.


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Kohsaka Masanobu, Takase Shigehiro, Uchida Itsuo, Terano Hiroshi, Iwami Morita, Hashimoto Masashi, Yamashita Michio, Komori Tadaaki: Composes tetracycliques; leur preparation et composition pharmaceutique qui en renferme, Tetracyclo compounds, a process for their production and a pharmaceutical composition containing the same. Fujisawa Pharmaceutical, OGILVY RENAULT SENCRLSRL, January 17, 1989: CA1248897

Abstract1. Title of Invention: NEW TETRACYCLO COMPOUNDS, A PROCESS FOR THEIRPRODUCTION AND A PHARMACEUTICAL COMPOSITIONCONTAINING THE SAME2. New tetracyclo compounds of the formula : Image (I)in which R1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl,arylaminomethyl, carboxy, pr ...