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Watanabe Hiroyuki, Kurasawa Osamu, Tarui Naoki, Yosemoto Takashi, Hirai Keisuke: Indole compound and application thereof. Takeda Chem, May 27, 2004: JP2004-149429 (35 worldwide citation)

PROBLEM TO BE SOLVED: To provide a novel compound having excellent β-secretase inhibitory actions or Aβ production/secretion/aggregation inhibitory actions.SOLUTION: The compound is represented by formula (I), where R1 denotes a halogen atom or a cyclic group which may have a substituent; R2 denotes ...


2
Uchikawa Osamu, Aso Kazuyoshi, Koike Tatsuki, Tarui Naoki, Hirai Keisuke: (Ja) 置換アミノ化合物およびその用途, (En) Substituted amino compounds and use thereof. Takeda Chemical Industries, Uchikawa Osamu, Aso Kazuyoshi, Koike Tatsuki, Tarui Naoki, Hirai Keisuke, KAWAMIYA Osamu, February 19, 2004: WO/2004/014843 (32 worldwide citation)

(EN) Compounds represented by the general formula (I) and &bgr;-secretase inhibitors containing the same: (I) wherein A is an aromatic ring which may have a substituent; R1 is aryl-C0-6 alkyl, heteroaryl-C0-6 alkyl, C1-6 alkyl, or the like, each being optionally substituted; R2 is hydrogen, optional ...


3
Miyamoto Masaomi, Matsui Junji, Fukumoto Hiroaki, Tarui Naoki: -Secretase inhibitors. Takeda Chemical Industries, February 12, 2003: EP1283039-A1 (20 worldwide citation)

An excellent beta secretase inhibitor is provided, which comprises a compound of the general formula: wherein Ar is an aromatic group; X is a divalent group selected from -O-, -S-, -CO-, -SO-, -SO2-, -NR-, -CONR-, -SO2NR-, and -COO- (wherein R is hydrogen, etc.), a divalent C1-6 aliphatic hydrocarbo ...


4
Kawano Yasuhiko, Matsumoto Tatsumi, Uchikawa Osamu, Fujii Nobuhiro, Tarui Naoki: Furoisoquinoline derivatives, process for producing the same and use thereof. Takeda Chemical Industries, January 2, 2003: EP1270577-A1 (17 worldwide citation)

A compound having a partial structure represented by Formula: or a salt thereof has an excellent phosphodiesterase (PDE) IV-inhibiting effect, and is useful as a prophylactic or therapeutic agent against inflammatory diseases, for example, bronchial asthma, chronic obstructive pulmonary disease (COP ...


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Kajino Masahiro, Hird Nicholas William, Tarui Naoki, Banno Hiroshi, Kawano Yasuhiko, Inatomi Nobuhiro: Fused quinoline derivative and use thereof. Takeda Pharmaceutical Company, Kajino Masahiro, Hird Nicholas William, Tarui Naoki, Banno Hiroshi, Kawano Yasuhiko, Inatomi Nobuhiro, TAKASHIMA Hajime, November 10, 2005: WO/2005/105802 (16 worldwide citation)

The present invention aims at provision of a quinoline derivative having a neurokinin 2 (NK2) receptor antagonistic action and relates to a compound represented by the formula (I) wherein Rl is a hydrogen atom and the like; R2 is a hydrogen atom, a hydrocarbon group optionally having substituent(s) ...


6
Miwa Tetsuo, Yamamoto Mitsuo, Doi Takayuki, Tarui Naoki: Pyrimidine-5-carboxamide compounds, process for producing the same and use thereof. Takeda Chemical Industries, July 17, 2002: EP1223170-A1 (11 worldwide citation)

A compound of the formula wherein R1 is a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 nitrogen atom(s), which heterocycle is attached by a secondary nitrogen atom constituting the heterocycle; X is an oxygen atom, a nitrogen atom optionally substituted by a hydrocarbon ...


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Kajino Masahiro, Hasuoka Atsushi, Tarui Naoki, Takagi Terufumi: (Ja) プロトンポンプ阻害薬, (En) Proton pump inhibitors. Takeda Pharmaceutical Company, Kajino Masahiro, Hasuoka Atsushi, Tarui Naoki, Takagi Terufumi, TAKASHIMA Hajime, April 6, 2006: WO/2006/036024 (10 worldwide citation)

(EN) Proton pump inhibitors which have excellent proton pumping activity and which can be converted in vivo into proton pump inhibitors to exhibit antiulcer effect and so on, containing compounds represented by the general formula (I) or salts thereof or prodrugs of the same: (I) wherein X and Y are ...


9
Kajino Masahiro, Hasuoka Atsushi, Tarui Naoki, Takagi Terufumi: Proton pump inhibitors. Takeda Pharmaceutical, July 4, 2007: EP1803709-A1 (9 worldwide citation)

A proton pump inhibitor containing a compound represented by the formula (I) wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R 1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R 2 ...


10
Kitada Chieko, Asami Taiji, Nishizawa Naoki, Otaki Tetsuya, Tarui Naoki, Matsumoto Hirokazu, Noguchi Jiro, Matsui Hisanori: Metastin derivative and application of the same. Takeda Chem, August 5, 2004: JP2004-217651 (8 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a metastin derivative excellent in stability in blood and having cancer transfer inhibiting action or cancer growth inhibiting action.SOLUTION: The metastin derivative is expressed by formula (I) (wherein Z1, Z3, Z5 and Z7 express each H oor a 1-3C alkyl; Z2, Z4, Z6 a ...