1
Chengbin Wu, Tariq Ghayur, Richard W Dixon, Jochen G Salfeld: Dual variable domain immunoglobulin and uses thereof. Abbott Laboratories, Tara Seshadri, Kenneth Zwicker, Yankwich & Associates P C, November 3, 2009: US07612181 (139 worldwide citation)

The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.


2
Chengbin Wu, Tariq Ghayur, Richard W Dixon, Jochen G Salfeld: Dual variable domain immunoglobulin and uses thereof. Abbott Laboratories, Peter Dini, Yankwich & Associates P C, September 4, 2012: US08258268 (46 worldwide citation)

The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.


3
Les Sekut, Adam Carter, Tariq Ghayur, Subhashis Banerjee, Daniel E Tracey: Methods and compositions for modulating responsiveness to corticosteroids. BASF Aktiengesellschaft, Lahive & Cockfield, April 25, 2000: US06054487 (34 worldwide citation)

Method for modulating responsiveness to corticosteroids in a subject are provided. In the method of the invention, an agent which antagonizes a factor that regulates production of IFN-.gamma. in the subject is administered to the subject in combination with a corticosteroid such that responsiveness ...


4
Albert Collinson, George Avgerinos, Richard Dixon, Tariq Ghayur, Zehra Kaymakcalan: Dual specificity antibodies and methods of making and using. Abbott Laboratories, Tara Sashadri, Kenneth P Zwicker, February 17, 2009: US07491516 (29 worldwide citation)

Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1α and IL-1β and neutralize IL-1α an ...


5
Tariq Ghayur, Rajesh V Kamath, Junian Liu, Marie P Honore: Dual variable domain immunoglobulins and uses thereof. AbbVie, Finnegan Henderson Farabow Garrett & Dunner, May 6, 2014: US08716450 (22 worldwide citation)

The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.


6
Tariq Ghayur, Junjian Liu, Sharmila Manoj, Susan E Brophy: Dual variable domain immunoglobulins and uses thereof. ABBVIE, Finnegan Henderson Farabow Garrett & Dunner L, November 19, 2013: US08586714 (19 worldwide citation)

The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.


7
Tariq Ghayur, Junjian Liu, Peter C Isakson: Dual variable domain immunoglobulins and uses thereof. AbbVie, Finnegan Henderson Farabow Garrett and Dunner, May 27, 2014: US08735546 (18 worldwide citation)

Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.


8
Tariq Ghayur, Jochen G Salfeld, Michael J McPherson, Maria C Harris, Junjian Liu, Peter C Isakson, Jijie Gu: Dual variable domain immunoglobulins and uses thereof. AbbVie, Finnegan Henderson Farabow Garrett & Dunner, May 13, 2014: US08722855 (16 worldwide citation)

The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.


9
Tariq Ghayur, Peter C Isakson, Lisa M Olson, Chengbin Wu, Margaret Hugunin, Rajesh V Kamath, Carolyn A Cuff, Hamish J Allen: Dual variable domain immunoglobulins and uses thereof. AbbVie, Finnegan Henderson Farabow Garrett & Dunner, May 19, 2015: US09035027 (14 worldwide citation)

The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.


10
Tariq Ghayur, Boris Labkovsky, Jeffrey W Voss, Larry Green, John Babcook, Xiao chi Jia, James Wieler, Jaspal Singh Kang, Brad Hedberg: IL-18 binding proteins. Abbott Laboratories, McCarter & English, Maria Laccotripe Zacharakis, Maneesh Gulati Esq, June 28, 2011: US07968684 (11 worldwide citation)

The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity i ...