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Tanamachi Dawn M, Brams Peter, Black Amelia: Transgenic animals expressing chimeric antibodies for use in preparing human antibodies. Medarex, Tanamachi Dawn M, Brams Peter, Black Amelia, GAVIN Kimberley A, October 18, 2007: WO/2007/117410 (50 worldwide citation)

The invention provides transgene constructs for expressing chimeric antibodies, and transgenic non-human host animals carrying such constructs, wherein the chimeric antibodies comprise human variable regions and constant regions of the non-human transgenic host animal. The presence of immunoglobulin ...


2
Bender Steven Lee, Casperson Gerald Fries, Hu Lowe Dana Dan, Jiang Xin, Li Gang, North Michael Aidan, Wang Jianying, Wickman Grant, Brams Peter, Huang Haichun, Devaux Brigitte, Chen Haibin, Tanamachi Dawn M, Toy Kristopher, Yang Lan, Sproul Tim W, Yamanaka Mark: Alpha 5 - beta 1 antibodies and their uses. Medarex, Pfizer, Bender Steven Lee, Casperson Gerald Fries, Hu Lowe Dana Dan, Jiang Xin, Li Gang, North Michael Aidan, Wang Jianying, Wickman Grant, Brams Peter, Huang Haichun, Devaux Brigitte, Chen Haibin, Tanamachi Dawn M, Toy Kristopher, Yang Lan, Sproul Tim W, Yamanaka Mark, BRADY James W, August 13, 2009: WO/2009/100110 (5 worldwide citation)

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells ...


3
Kuhne Michelle, Brams Peter, Tanamachi Dawn M, Korman Alan, Cardarelli Josephine M: Human antibodies that bind cxcr4 and uses thereof. Medarex, Kuhne Michelle, Brams Peter, Tanamachi Dawn M, Korman Alan, Cardarelli Josephine M, DECONTI Giulio A, May 22, 2008: WO/2008/060367 (3 worldwide citation)

The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of ...


4
Tanamachi Dawn M, Brams Peter, Black Amelia: Transgenic animals expressing chimeric antibodies for use in preparing human antibodies. Medarex, December 24, 2008: EP2003960-A2 (1 worldwide citation)

The invention provides transgene constructs for expressing chimeric antibodies, and transgenic non-human host animals carrying such constructs, wherein the chimeric antibodies comprise human variable regions and constant regions of the non-human transgenic host animal. The presence of immunoglobulin ...


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KUHNE MICHELLE, BRAMS PETER, TANAMACHI DAWN M, KORMAN ALAN, CARDARELLI JOSEPHINE M: Human antibodies that bind CXCR4 and uses thereof, CXCR4-bindende humane Antikörper und deren Verwendungen, Anticorps humains liant le CXCR4 et utilisations associées. MEDAREX, August 15, 2012: EP2486941-A1

The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of ...


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TANAMACHI DAWN M, BRAMS PETER, BLACK AMELIA: Animaux transgéniques exprimant des anticorps chimériques pour une utilisation dans la préparation danticorps humains, Chimäre Antikörper exprimierende transgene Tiere für die Zubereitung humaner Antikörper, Transgenic animals expressing chimeric antibodies for use in preparing human antibodies. MEDAREX, October 3, 2012: EP2505058-A1

The invention provides transgene constructs for expressing chimeric antibodies, and transgenic non-human host animals carrying such constructs, wherein the chimeric antibodies comprise human variable regions and constant regions of the non-human transgenic host animal. The presence of immunoglobulin ...


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Kuhne Michelle, Brams Peter, Tanamachi Dawn M, Korman Alan, Cardarelli Josephine M: Human antibodies that bind cxcr4 and uses thereof. Medarex, June 10, 2009: EP2066351-A2

The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of ...


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Rao Naik Chetana, King David John, Liu Jie, Huang Haichun, Passmore David B, Bell Alasdair Fraser, Cardarelli Josephine M, Pan Chin, Thi Do To Uyen, Chen Sharline, Tanamachi Dawn M: Cd19 antibodies and their uses. Medarex, March 19, 2008: EP1899379-A2

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD 19 with high affinity. Nucleic acid molecules encoding such CD 19 antibodies, expression vectors, host cells and methods for expressing the CD 19 antibodies are also ...