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Hemmi Keiji, Neya Masahiro, Fukami Naoki, Hashimoto Masashi, Tanaka Hirokazu, Kayakiri Natsuko: Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same.. Fujisawa Pharmaceutical Co, November 21, 1991: EP0457195-A2 (66 worldwide citation)

The present invention relates to peptide compound and a pharmaceutically acceptable salt thereof which have pharmacological activities such as endothelin antagonistic activity and the like, to processes for its preparation, to a pharmaceutical composition comprising the same, and to a method of usin ...


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Oku Teruo, Kawai Yoshio, Marusawa Hiroshi, Yamazaki Hitoshi, Abe Yoshito, Tanaka Hirokazu: Condensed pyrazole derivatives with interleukin-1 and tumour necrosis factor inhibitory activity.. Fujisawa Pharmaceutical Co, March 17, 1993: EP0531901-A2 (55 worldwide citation)

1. A compound of the formula : wherein R is aryl which may have suitable substituent(s) or heterocyclic group which may have suitable substituent(s), R is aryl which may have suitable substituent(s) or heterocyclic group which may have suitable substituent(s), and Y is a bivalent radical selected fr ...


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Oku Teruo, Kayakiri Hiroshi, Satoh Shigeki, Abe Yoshito, Yuki Sawada, Tanaka Hirokazu: Imidazo (1,2-a) pyridines as bradykinin antagonists.. Fujisawa Pharmaceutical Co, May 11, 1994: EP0596406-A1 (54 worldwide citation)

A compound of the formula : wherein R is halogen, R and R are each hydrogen, lower alkyl, halo(lower)alkyl or acyl, R is aryl having suitable substituent(s), or a heterocyclic group optionally having suitable substituent(s), Q is O or N-R, in which R is hydrogen or acyl, and A is lower alkylene, and ...


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Oku Teruo, Setoi Hiroyuki, Kayakiri Hiroshi, Inoue Takayuki, Kuroda Akio, Katayama Akira, Hashimoto Masashi, Satoh Sigeki, Tanaka Hirokazu: Condensed imidazole derivatives and processes for preparation thereof.. Fujisawa Pharmaceutical Co, May 8, 1991: EP0426021-A1 (48 worldwide citation)

A compound of the formula : wherein R is lower alkyl, halo(lower)alkyl, cyclo(lower)alkyl or lower alkylthio, R is hydrogen or imino-protective group, R is hydrogen or halogen, A is lower alkylene, and is a group of the formula : in which X, X, X and X are each N or CR, in which R is hydrogen, lower ...


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Oku Teruo, Kayakiri Hiroshi, Satoh Shigeki, Abe Yoshito, Sawada Yuki, Inoue Takayuki, Tanaka Hirokazu: Heterocyclic compounds as bradykinin antagonists.. Fujisawa Pharmaceutical Co, November 2, 1994: EP0622361-A1 (43 worldwide citation)

A compound of the formula : wherein X is N or C-R, X is N or C-R, X is N or C-R, R is hydrogen or halogen, R is halogen, R is hydrogen, nitro, amino optionally having suitable substituent(s) or a heterocyclic group optionally having suitable substituent(s), R and R are each hydrogen or halogen, R an ...


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Oku Teruo, Setoi Hiroyuki, Kayakiri Hiroshi, Satoh Shigeki, Inoue Takayuki, Saitoh Yuki, Kuroda Akio, Tanaka Hirokazu: Imidazole derivatives, potent and selective antagonists of angiotensin ii receptor.. Fujisawa Pharmaceutical Co, April 15, 1992: EP0480204-A1 (38 worldwide citation)

A compound of the formula : wherein R is hydrogen, halogen, nitro, lower alkyl, lower alkoxy, amino or acylamino, R, R and R are each hydrogen, halogen, nitro, cyano, lower alkyl, lower alkenyl, lower alkylthio, more or di or trihalo(lower)alkyl, oxo(lower)alkyl, hydroxy(lower)alkyl or optionally es ...


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Kitaura Yoshihiko, Nakaguchi Osamu, Hemmi Keiji, Aratani Matsuhiko, Takeno Hidekazu, Okada Satoshi, Tanaka Hirokazu, Hashimoto Masashi, Kuroda Yoshio, Iguchi Eiko, Kohsaka Masanobu, Aoki Hatsuo, Imanaka Hiroshi: New lactyl tetrapeptide, processes for preparation thereof and pharmaceutical compositions containing it.. Fujisawa Pharmaceutical Co, May 28, 1980: EP0011283-A1 (24 worldwide citation)

A lactyl tetrapeptide of the formula can be prepared by conventional peptide synthesis. One isomer, FR 900156, is obtained by cultivation of a suitable Streptomyces strain such as Str. violaceus ATCC 31481 or Str. olivaceogriseus ATCC 31427. The invention also relates to a pharmaceutical composition ...


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Oku Teruo, Setoi Hiroyuki, Kayakiri Hiroshi, Satoh Shigeki, Inoue Takayuki, Sawada Yuki, Kuroda Akio, Tanaka Hirokazu: Imidazo 4,5-b pyridine derivatives as angiotensin ii antagonists.. Fujisawa Pharmaceutical Co, August 4, 1993: EP0553682-A1 (22 worldwide citation)

A compound of the formula : wherein R is hydrogen, halogen, nitro, lower alkyl, lower alkoxy, amino or acylamino, R, R and R are each hydrogen, halogen, nitro, cyano, lower alkyl, lower alkenyl, lower alkylthio, mono or di or trihalo(lower)alkyl, oxo(lower)alkyl, hydroxy(lower)alkyl or optionally es ...