1
Tamaki Kazuhiko, Yamaguchi Takahiro, Oda Kozo, Terasaka Naoki, Nakai Daisuke, Nakadai Masakazu: (Ja) 2以上の置換基を有するベンゼン化合物, (En) Benzene compound having 2 or more substituents. Daiichi Sankyo Company, Tamaki Kazuhiko, Yamaguchi Takahiro, Oda Kozo, Terasaka Naoki, Nakai Daisuke, Nakadai Masakazu, YAGUCHI Toshiaki, May 4, 2006: WO/2006/046593 (45 worldwide citation)

(EN) Disclosed is an excellent LXR modulator. Specifically disclosed is a compound represented by the general formula (I) below or the like. (I) [In the formula, R1 represents a -COR9 (wherein R9 represents an alkyl, optionally substituted alkoxy or optionally substituted amino); R2 represents an H, ...


2
Kimura Tomio, Tamaki Kazuhiko, Miyazaki Shojiro, Kurakata Shinichi, Fujiwara Kosaku: Medicine composition containing sulfonamid compound. Sankyo, October 3, 2002: JP2002-284686 (5 worldwide citation)

PROBLEM TO BE SOLVED: To provide matrixmetalloproteinase inhibitor.SOLUTION: Medicine compositions containing a compound having a general formula (I), pharmacollogically acceptable salts, esters, or other derivatives thereof as active ingredient, wherein R1: OH, NHOH; R2: groups having a formula (II ...


3
Tamaki Kazuhiko, Yamaguchi Takahiro, Oda Kozo, Terasaka Naoki, Nakai Daisuke, Nakadai Masakazu: Benzene compound having 2 or more substituents. Daiichi Sankyo, July 11, 2007: EP1806332-A1 (3 worldwide citation)

A superior LXR modulator is provided. A compound represented by the general formula (I): [wherein R 1 : -COR 9 (wherein R 9 : alkyl, optionally substituted alkoxy or optionally substituted amino); R 2 : H, OH, alkoxy, optionally substituted amino, etc.; R 3 : H, optionally substituted alkyl, cycloal ...


4
YAMAGUCHI Takahiro, YOSHIDA Masayuki, TAMAKI Kazuhiko: [ja] 置換ベンゼン化合物, [fr] COMPOSÉ DU BENZÈNE SUBSTITUÉ, [en] SUBSTITUTED BENZENE COMPOUND. YAMAGUCHI Takahiro, YOSHIDA Masayuki, TAMAKI Kazuhiko, SANKYO COMPANY, YAGUCHI Toshiaki, January 12, 2006: WO/2006/003923 (3 worldwide citation)

[en] Disclosed is an excellent LXR modulator. Specifically disclosed are compounds represented by the following general formula (I). (In the formula, R1 represents -COR9 (wherein R9 represents an alkyl, an optionally substituted alkoxy or an optionally substituted amino or the like), an optionally s ...


5
Yamaguchi Takahiro, Yoshida Masayuki, Tamaki Kazuhiko: Medicine comprising substituted benzene compound. Sankyo, July 12, 2007: JP2007-176799 (2 worldwide citation)

PROBLEM TO BE SOLVED: To carry out intensive studies on synthesis and a pharmacological activity of a substituted benzene compound in order to find out a compound having an excellent binding activity for an LXR (liver X receptor) and to provide an excellent LXR modulator which is the substituted ben ...


6
Arai Masami, Yamazaki Takanori, Tamaki Kazuhiko: (Ja) インドール化合物, (En) Indole compounds. Sankyo Company, Arai Masami, Yamazaki Takanori, Tamaki Kazuhiko, YAGUCHI Toshiaki, December 1, 2005: WO/2005/113499 (2 worldwide citation)

(EN) The invention provides excellent LXR regulators, that is, compounds represented by the general formula (I): wherein R1, R2, R3 and R4 are each H, alkyl, alkoxy, substituted amino, halogeno, or the like; R5 is H, alkyl, or halogeno; R6 is -COR8 (wherein R8 is alkoxy, phenyloxy, substituted amino ...


7
Tamaki Kazuhiko, Yamaguchi Takahiro, Terasaka Naoki: (Ja) 置換インドール化合物, (En) Substituted indole compound. Daiichi Sankyo Company, Tamaki Kazuhiko, Yamaguchi Takahiro, Terasaka Naoki, YAGUCHI Toshiaki, October 19, 2006: WO/2006/109633 (2 worldwide citation)

(EN) Disclosed is an excellent LXR modulator. A compound represented by the general formula (I): (I) wherein R1, R2, R3 and R4: H, an alkyl which may be substituted, OH, an alkoxy which may be substituted, an amino which may be substituted, a halogeno, a phenyl or the like; R5: H or an alkyl; R6: -C ...


8
Tamaki Kazuhiko, Hayakawa Satoshi, Fujita Hiroyuki, Hirose Hiromasa: Stocking transfer apparatus. Nagata Seiki, May 20, 2004: JP2004-143614 (2 worldwide citation)

PROBLEM TO BE SOLVED: To provide a stocking transfer apparatus which can eliminate the interference of transfer bits with transfer needles and can stably transfer the loops of knitting needles to the transfer needles.SOLUTION: This stocking transfer apparatus is characterized by more reduce the oute ...


9
Sugimura Yukio, Tamaki Kazuhiko, Kobayashi Tomowo, Tanzawa Kazuhiko: Collagenase inhibitor.. Sankyo, October 26, 1994: EP0621270-A1 (1 worldwide citation)

Constitution: a novel compound represented by general formula (1), wherein R represents -OR (R being H or alkyl), -NRR (R and R being each H, alkyl or alkoxy), -NHCH(R)COR (R being H or alkyl, and R being alkyl), -NHCH(R)COOR(R being alkyl) or -NHCH(R)CONRR (R and R being each H or alkyl, or alterna ...


10
Yamaguchi Takahiro, Yoshida Masayuki, Tamaki Kazuhiko: Substituted benzene compound. Sankyo, February 16, 2006: JP2006-045203 (1 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a substituted benzene compound that ameliorates lipid metabolism abnormality by modulating action of liver X receptors (LXR) and exhibits excellent anti-arteriosclerotic action and antiinflammation action by controlling formation of inflammation mediator or its pharma ...