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Gong Leyi, Kertesz Denis John, Smith David Bernard, Talamas Francisco Xavier, Wilhelm Robert Stephen: Ccr-3 receptor antagonists. Hoffmann La Roche, March 24, 1999: EP0903349-A2 (86 worldwide citation)

This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.


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Labadie Sharada Shenvi, Lin Clara Jeou Jen, Talamas Francisco Xavier, Weikert Robert James: Heterocyclic antiviral compounds. F Hoffmann La Roche, Labadie Sharada Shenvi, Lin Clara Jeou Jen, Talamas Francisco Xavier, Weikert Robert James, KJELLSAA BERGER Hanny, August 20, 2009: WO/2009/101022 (21 worldwide citation)

Compounds having the formula (I) wherein Y, R1, R4, A1, A2 and X2 are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.


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Talamas Francisco Xavier, Caroon Joan Marie, Dunn Robert, Hopper Allen, Kuester Eric, Schumacher Richard, Tehim Ashok: Trisubstituted amines as phosphodiesterase 4 inhibitors. Memory Pharmaceuticals Corporation, F Hoffmann La Roche, Talamas Francisco Xavier, Caroon Joan Marie, Dunn Robert, Hopper Allen, Kuester Eric, Schumacher Richard, Tehim Ashok, HEANEY Brion P, December 21, 2006: WO/2006/135828 (11 worldwide citation)

PDE4 inhibition is achieved by novel compounds,' e.g., N-substituted diarylamine analogs. The compounds of the present invention are of Formulas I-III; (I), (II) and (III) wherein A, B, D, E, G, J, K, R1, R2, R3, R4, R11, R12, R13, R14, R21, R22, R23 and R24 are as defined herein.


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ABBOT Sarah C, LI Jim, LUI Alfred Sui Ting, TALAMAS Francisco Xavier: [fr] COMPOSÉS ANTIVIRAUX HÉTÉROCYCLIQUES, [en] HETEROCYCLIC ANTIVIRAL COMPOUNDS. F HOFFMANN LA ROCHE, ABBOT Sarah C, LI Jim, LUI Alfred Sui Ting, TALAMAS Francisco Xavier, KJELLSAA BERGER Hanny, September 10, 2010: WO/2010/100178 (7 worldwide citation)

[en] Compounds having the formula A-R wherein A is a hetereoaryl and R is Ia, Ib or Ic and wherein A, R, R1, R2a, R2b, R2c, R3a, R3b, R4, R5, R6, Ra, Rb, Rc, Rd, X, X1, X2 and n are as are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods ...


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Talamas Francisco Xavier, Wang Beihan: Thienopyridines as ikk inhibitors. F Hoffmann La Roche, Talamas Francisco Xavier, Wang Beihan, HEIROTH Ulrike, November 10, 2005: WO/2005/105809 (5 worldwide citation)

The invention is concerned with a compound of formula (I) or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein A, W, X, Y, Z and R1 are as defined in the description and the claims. These compounds inhibit IKK and can be used as medicaments.


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Brameld Kenneth Albert, Carter David Scott, Chin Elbert, de Vicente Fidalgo Javier, Li Jim, Schoenfeld Ryan Craig, Sjogren Eric Brian, Talamas Francisco Xavier: Heterocyclic antiviral compounds. F Hoffmann La Roche, Brameld Kenneth Albert, Carter David Scott, Chin Elbert, de Vicente Fidalgo Javier, Li Jim, Schoenfeld Ryan Craig, Sjogren Eric Brian, Talamas Francisco Xavier, Kjellsaa Berger Hanny, January 28, 2010: WO/2010/010017 (4 worldwide citation)

Compounds having the formula (I) wherein R1, R2, R3, R4a' R4b' R4c', R5, R6, R9 and n are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.


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Gong Leyi, Kertesz Denis John, Smith David Bernard, Talamas Francisco Xavier, Wilhelm Robert Stephen: Cyclic amine derivatives. Hoffmann La Roche, April 28, 1999: GB2330580-A (3 worldwide citation)

Cyclic amine derivatives of Formula (I) where the symbols are as defined in the specification, are CCR-3 receptor antagonists. Novel intermediates have the formula:


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