1
Yoshio Ueda, Takehisa Hata, Hisami Yamaguchi, Satoshi Ueda, Masateru Kodani: Time-controlled explosion systems and processes for preparing the same. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, October 3, 1989: US04871549 (121 worldwide citation)

The invention relates to a Time-Controlled Explosion System in which drug release is caused by explosion of a membrane after a definite time period, said System comprising a preparation in the form of a bead or granule, said preparation comprising a core, a drug, swelling agent and an outer membrane ...


2
Takashi Morishita, Takehisa Hata, Mitio Mori, Shohachi Tanoue: Multiple soft capsules and production thereof. Morishita Jintan, Fujisawa Pharmaceutical, Oblon Fisher Spivak McClelland & Maier, September 22, 1987: US04695466 (96 worldwide citation)

The present invention relates to a multiple soft capsule in which a soft capsule is contained in another soft capsule and the production thereof. The multiple soft capsule is useful for various industrial fields such as medicine, foods, table luxuries and the like. Especially, the multiple capsule i ...


3
Akira Kagayama, Sumihisa Kimura, Saburo Murata, Sachiyo Tanimoto, Takehisa Hata: Sustained release medicinal preparation. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, February 11, 1997: US05601844 (53 worldwide citation)

A sustained release medicinal preparation is produced by enclosing a macrocyclic compound represented by 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylviny l)-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1 .0.sup.4,9 ]octacos-18-ene-2,3,10,16-tetraon ...


4
Saburo Murata, Fumio Shiomojo, Yuji Tokunaga, Takehisa Hata: Aerosol compositions. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, March 26, 2002: US06361760 (35 worldwide citation)

The use of a medium-chain fatty acid triglyceride as the dispersant in the preparation of a medicinal aerosol composition comprising tricyclic compound (I) dispersed in a liquefied hydrofluoroalkane propellant is described. When a liquefied hydrofluoroalkane is added to a kneaded premix of the tricy ...


5
Takehisa Hata, Nobuto Kanagawa, Takashi Morishita, Toshiyuki Suzuki: Type soft capsule. Fujisawa Pharmaceutical, Morishita Jintan, Oblon Fisher Spivak McClelland & Maier, September 1, 1987: US04690816 (26 worldwide citation)

A soft capsule which is prepared by wrapping an oily substance which is a member selected from the group consisting of tricaprylic acid glyceride and sesame oil, with a gelatin film containing sodium picosulfate.


6
Yoshio Ueda, Takehisa Hata, Rinta Ibuki, Kazutake Kado, Hiroshi Ishikuro: Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter. Fujisawa Pharmaceutical Company, Oblon Spivak McClelland Maier & Neustadt, September 3, 1991: US05045553 (16 worldwide citation)

The present invention relates to a pharmaceutical composition for percutaneous drug absorption which comprises 5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and ethanol and/or an unsaturated higher fatty acid and to a composition of matter which compr ...


7
Takehisa Hata, Yuji Tokunaga, Fumio Shimojo, Sumihisa Kimura, Takeo Hirose, Satoshi Ueda: Medicinal composition. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, February 12, 2002: US06346537 (16 worldwide citation)

To provide a pharmaceutical composition comprising a water-insoluble active substance, surfactant(s) and solid carrier(s), which is improved in dissolution and oral absorption characteristics.


8
Takehisa Hata, Akira Kagayama, Sumihisa Kimura, Satoshi Ueda, Saburo Murata: Delayed action preparation. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, August 5, 1997: US05654009 (15 worldwide citation)

The invention relates to a delayed action preparation which comprises a core comprising a drug and a swelling agent and an outer membrane comprising a biodegradable high molecular weight substance characterized in that the swelling agent is contained in a sufficient amount to cause a explosion of th ...


9
Akira Kagayama, Sachiyo Tanimoto, Saburo Murata, Takehisa Hata: Lotion for FK 506. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, August 17, 1999: US05939427 (8 worldwide citation)

A lotion comprising a tricyclic compound, typically 17-allyl-1,14-dihydroxy-12-�2-(4-hydroxy-3-methoxycyclohexyl)-1-methylviny l!-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo �22.3.1.0.sup.4,9 !octacos-18-ene-2,3,10,16-tetraone, or a pharmaceutically acceptable salt thereof, a s ...


10
Toshiyasu Honbo, Sachiyo Tanimoto, Hiromitsu Yoshida, Takehisa Hata, Sotoo Asakura, Yasuto Koyama, Youhei Kiyota: Aqueous liquid composition for external use. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, June 23, 1998: US05770607 (8 worldwide citation)

This invention relates to an aqueous liquid composition for external use which contains a tricyclo compound of the chemical formula (I) presented here-under or a pharmaceutically acceptable salt thereof. More particularly, the invention relates to an aqueous liquid composition for external use chara ...