1
Tsunoda Hidetoshi, Fukazawa Nobuyuki, Maruyama Kyoko, Nakao Toshifumi, Asada Noriaki, Takebayashi Nozomi, Kobayashi Kenji, Uda Hideyuki, Morikawa Maki: Catecholpropionic acid derivative and nuclear receptor agonist containing the same as active ingredient. Mitsui Chemicals, September 26, 2001: JP2001-261612 (11 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a prophylactic or therapeutic agent for various kinds of diseases, e.g. diabetes mellitus, hyperlipidemia, arteriosclerosis, etc., by activating peroxisome proliferator-activated receptor(PPAR)-α or -γ which is a nuclear transcription factor and relates to the disease ...


2

3
Yoshida Arikata, Miyamoto Michihiko, Kobayashi Hideki, Kawashima Miyuki, Takebayashi Nozomi: Polyamino acid derivative imparted with fixability to living body. Mitsui Chemicals, August 2, 2007: JP2007-191643 (8 worldwide citation)

PROBLEM TO BE SOLVED: To provide a biocompatible material enabling its active ingredients to be sustainably and suitably functioned in cosmetics, pharmaceuticals, medical materials and regenerative medical materials.SOLUTION: The biocompatible material comprises a polyamino acid derivative composed ...


4

5
Nakao Toshifumi, Matsue Kaori, Takebayashi Nozomi: Cell useful for evaluation of sex hormone receptor action. Mitsui Chemicals, September 3, 2002: JP2002-247986 (1 worldwide citation)

PROBLEM TO BE SOLVED: To provide a method for measuring an antagonist or antagonist activity having high specificity of a substance to be examined to a nuclear receptor in high accuracy by using the nuclear receptor gene such as a steroidal hormone receptor and a stable expression stock of a reporte ...


6

7
Nakao Toshifumi, Takebayashi Nozomi: Androgen receptor action inhibitor. Mitsui Chemicals, November 15, 2002: JP2002-326931 (1 worldwide citation)

PROBLEM TO BE SOLVED: To provide a new androgen receptor action inhibitor having high anti-androgenic activity, stability and safety.SOLUTION: This androgen receptor action inhibitor comprises 5- hydroxyflavone as an active ingredient. The 5-hydroxyflavone exhibits extremely high androgen receptor a ...


8

9

10
MATSUMOTO YOSHIKO, HIRANO JUNICHIRO, MORISHIGE TAKASHI, SHIRAI TOMOKAZU, TAKAHASHI HITOSHI, AMANO KOH, TAKEBAYASHI NOZOMI, WADA MITSUFUMI, SHIMIZU HIROSHI, FURUSAWA CHIKARA, HIRASAWA TAKASHI: BACTÉRIE PRODUISANT DE LALCOOL ISOPROPYLIQUE DE MANIÈRE HAUTEMENT PRODUCTIVE., HOCHPRODUKTIVES ISOPROPYLPRODUZIERENDES BAKTERIUM, HIGHLY PRODUCTIVE ISOPROPYL ALCOHOL-PRODUCING BACTERIUM. Mitsui Chemicals, January 16, 2013: EP2546331-A1

An isopropyl alcohol-producing Escherichia coli equipped with an isopropyl alcohol production system, having at least one enhanced enzyme activity selected from the group consisting of an enhanced malate dehydrogenase, activity, an enhanced NAD(P) + transhydrogenase (AB-specific) activity, and an en ...