1
Yasushi Kohno, Naoki Ando, Takahiro Tanase, Kazuhiko Kuriyama, Satoru Iwanami, Shinji Kudou: Diaryl ether derivative, addition salt thereof, and immunosuppressant. Kyorin Pharmaceutical, Wenderoth Lind & Ponack L, November 8, 2005: US06963012 (14 worldwide citation)

The present invention provides diaryl ether derivatives that exhibit significant immunosuppressive effects with less side effects. The diaryl derivatives of the present invention are represented by the following general formula (1): one example is 2-amino-2-[4-(3-benzyloxyphenoxy)-2-chlorophenyl]pro ...


2
Hiroyuki Miyachi, Masahiro Nomura, Takahiro Tanase, Koji Murakami, Masaki Tsunoda: Substituted benzylthiazolidine-2, 4-dione derivatives. Kyorin Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, May 4, 2004: US06730687 (9 worldwide citation)

The invention provides novel substituted benzylthiazolidine-2,4-dione derivatives that bind to receptor to activate as ligands of human peroxisome proliferator-activated receptor (PPAR) and exhibit blood glucose-decreasing action and lipid-decreasing action, and processes for preparing them.


3
Masahiro Nomura, Yukie Takahashi, Takahiro Tanase, Hiroyuki Miyachi, Masaki Tsunoda, Tomohiro Ide, Koji Murakami: Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor (PPAR) &agr;. Kyorin Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, January 14, 2003: US06506797 (9 worldwide citation)

The invention provides novel substituted phenylpropanoic acid derivatives that activate by binding to receptor as ligands of human peroxisome preliferant-activated receptor &agr; (PPAR&agr;), and exhibit potent decreasing action on lipids in blood (cholesterol and triglyceride).


4
Hiroyuki Miyachi, Masahiro Nomura, Yukie Takahashi, Takahiro Tanase, Kouji Murakami, Masahiro Suzuki: Substituted phenylpropionic acid derivatives. Kyorin Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, May 23, 2006: US07049342 (3 worldwide citation)

The invention provides novel substituted phenylpropionic acid derivatives that bind to the receptor as ligands of human peroxisome proliferator-activated receptor ╬▒ (PPAR╬▒) to activate and exhibit potent lipid-decreasing action, and processes for preparing them. It relates to substituted phenylpropi ...


5
Hiroyuki Miyachi, Masahiro Nomura, Takahiro Tanase, Koji Murakami, Masaki Tsunoda: Substituted benzylthiazolidine-2, 4-dione derivatives. Kyorin Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, May 11, 2004: US06734199 (1 worldwide citation)

The invention provides novel substituted benzylthiazolidine-2,4-dione derivatives which increase the transactivation action of receptor as a ligand of human peroxisome proliferator-activated receptor (PPAR) and exhibit the blood glucose-decreasing action and lipid-decreasing action, and a process fo ...


6
Yasushi Kohno, Naoki Ando, Takahiro Tanase, Kazuhiko Kuriyama, Satoru Iwanami, Shinji Kudou: Diaryl ether derivative, addition salt thereof, and immunosuppressant. Wenderoth Lind & Ponack, December 2, 2004: US20040242654-A1

The present invention provides diaryl ether derivatives that exhibit significant immunosuppressive effects with less side effects. The diaryl derivatives of the present invention are represented by the following general formula (1): 1 one example is 2-amino-2-[4-(3-benzyloxyphenoxy)-2-chlorophenyl]p ...


7
Hiroyuki Miyachi, Masahiro Nomura, Yukie Takahashi, Takahiro Tanase, Kouji Murakami, Masahiro Suzuki: Substituted phenylpropionic acid derivatives. Oblon Spivak Mcclelland Maier & Neustadt PC, October 2, 2003: US20030187068-A1

The invention provides novel substituted phenylpropionic acid derivatives that bind to the receptor as ligands of human peroxisome proliferator-activated receptor a (PPAR) to activate and exhibit potent lipid-decreasing action, and processes for preparing them. It relates to substituted phenylpropio ...