1
Hiroitsu Kawata, Masayoshi Aruga, Tadayoshi Ohmura, Takashi Sonobe, Satoru Yoneya, Chiharu Sone: Sustained release pharmaceutical composition of solid medical material. Yamanouchi Pharmaceutical, Burgess Ryan & Wayne, September 13, 1983: US04404183 (106 worldwide citation)

Sustained release pharmaceutical compositions of a solid medical material which contains an amorphous solid medical material, polyethylene oxide, and at least one basic substance selected from the group consisting of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, methyl cellulose, polyvinyl ...


2
Hiroitsu Kawata, Masayoshi Aruga, Tadayoshi Ohmura, Takashi Sonobe, Satoru Yoneya, Chiharu Sone: Sustained release pharmaceutical composition of solid medical material. Yamanouchi Pharmaceutical, Burgess Ryan and Wayne, August 10, 1982: US04343789 (102 worldwide citation)

Sustained release pharmaceutical composition of a solid medical material which contains an amorphous solid medical material, polyethylene oxide, and at least one basic substance selected from the group consisting of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, methyl cellulose, polyvinyl ...


3
Hiroitsu Kawata, Tadayoshi Ohmura, Katsuhiko Yano, Mikio Matsumura, Saburo Higuchi, Yoshiaki Soeishi: Nifedipine-containing solid preparation composition. Yamanouchi Pharmaceutical, Sprung Horn Kramer & Woods, November 1, 1983: US04412986 (82 worldwide citation)

A novel nifedipine-containing solid pharmaceutical preparation composition comprising a mixture of nifedipine and at least one 1st(a) substance selected from polyvinyl pyrrolidone, methyl cellulose, hydroxypropyl cellulose and hydroxypropylmethyl cellulose; a mixture of nifedipine, at least one 1st( ...


4
Hiroitsu Kawata, Masayoshi Aruga, Tadayoshi Ohmura, Takashi Sonobe, Satoru Yoneya, Chiharu Sone: Sustained release pharmaceutical composition of solid medical material. Yamanouchi Pharmaceutical, Burgess Ryan & Wayne, June 16, 1987: US04673564 (49 worldwide citation)

Sustained release pharmaceutical compositions of a solid medical material which contains an amorphous solid medical material, polyethylene oxide, and at least one basic substance selected from the group consisting of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, methyl cellulose, polyvinyl ...


5
Katsuhiko Yano, Yasuhiro Nishizono, Shigeru Yamazaki, Tadayoshi Ohmura, Shunji Hasumi: Quick-dissolution solid preparation. Yamanouchi Pharmaceutical, Burgess Ryan and Wayne, April 29, 1997: US05624687 (21 worldwide citation)

The invention provides a solid preparation having a quick and pH-independent dissolution with an excellent bioavailability for a drug that is otherwise sharply depressed in solubility with pH elevation. This solid preparation contains granules each comprising a fine particulate core coated with a so ...


6
Hiroitsu Kawata, Tadayoshi Ohmura, Shunji Hasumi, Yutaka Konno, Masayoshi Aruga, Seiki Tashiro, Toshimitsu Konno, Ken Iwai: Oily compositions of antitumor drugs. Yamanouchi Pharmaceutical, Burgess Ryan & Wayne, March 25, 1986: US04578391 (13 worldwide citation)

An oily composition of an antitumor drug comprising at least one sparingly oil soluble or water-soluble antitumor drug, at least one fat or oil, and at least one solubilizing adjuvant in an oily vehicle selected from the group consisting of crown ether, lecithin, polyethylene glycol, propylene glyco ...


7
Takashi Sonobe, Hiroitsu Kawata, Masayoshi Aruga, Tadayoshi Ohmura, Satoru Yoneya, Chiharu Yamada, Yukio Kubota: Composition for long acting nicardipine preparation and process of producing the composition. Yamanouchi Pharmaceutical, Burgess Ryan & Wayne, July 19, 1988: US04758437 (10 worldwide citation)

A spherical pellet like composition of nicardipine composed of small granular nuclei such as sugar particles coated with amorphous nicardipine or a salt thereof, a pH-dependent additive and a surface active agent. The spherical pellet like composition of nicardipine may have a further coating of a m ...


8
Masuo Murakami, Hiroitsu Kawada, Tadayoshi Ohmura, Hiroshi Sugiura: Solid composition. Yamanouchi Pharmaceutical, Burgess Ryan and Wayne, March 22, 1977: US04013773 (10 worldwide citation)

A single phase solid composition wherein one part of a non-aqueous liquid and 0.5-6 parts of calcium lactate hydrate are mixed and heated. The product according to this invention is very stable and can be formed into various kinds of moldings by a simple operation so that it may be applied to many u ...


9
Tadayoshi Ohmura, Muneo Fukui, Hiroshi Sugiura, Satoru Yoneya, Toshiharu Hosono, Atsushi Kajiyama: Drug-release controlling coating material for long acting formulations. Yamanouchi Pharmaceutical, Burgess Ryan & Wayne, July 2, 1991: US05028664 (8 worldwide citation)

A coating material for controlling drug release, useful for long acting formulations--e.g. for once-a-day administration, and to a long acting granular composition comprising a drug (especially one conventionally difficult to prepare in long acting form) coated with the coating material. This compos ...


10
Hiroitsu Kawata, Tadayoshi Ohmura, Hiroyoshi Shiozawa, Munetaka Hattori: Coating agents for solid medicaments. Yamanouchi Pharmaceutical, Burgess Ryan and Wayne, March 24, 1981: US04258179 (5 worldwide citation)

A novel coating agent for solid medicaments containing a hydrogel-like substance of a water-insoluble hydroxypropyl cellulose having 5-16% by weight of a hydroxypropoxy group or the dry powder of a hydrogel-like substance. By coating solid medicaments with the coating agent, solid medicaments having ...



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