1
Kalyan Handique, Karthik Ganesan, Sundaresh N Brahmasandra: Methods and systems for control of microfluidic devices. HandyLab, Fish & Richardson P C, March 7, 2006: US07010391 (127 worldwide citation)

The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined configurations. Such microfluidic devices are preferably constructed in a hierarchical and modular fashion wh ...


2
Kalyan Handique, Sundaresh N Brahmasandra, Karthik Ganesan, Jeff Williams: Microfluidic system for amplifying and detecting polynucleotides in parallel. HandyLab, Knobbe Martens Olson & Bear, August 16, 2011: US07998708 (74 worldwide citation)

The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. ...


3
Kalyan Handique, Sundaresh N Brahmasandra, Karthik Ganesan, Jeff Williams: Microfluidic system for amplifying and detecting polynucleotides in parallel. HandyLab, Knobbe Martens Olson & Bear, December 4, 2012: US08323900 (65 worldwide citation)

The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. ...


4
Betty Wu, John S Althaus, Sundaresh N Brahmasandra, Kalyan Handique, Nikhil Phadke: Processing polynucleotide-containing samples. Handylab, Knobbe Martens Olson & Bear, June 25, 2013: US08470586 (52 worldwide citation)

Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that regain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under ...


5
Sundaresh N Brahmasandra, Elizabeth Craig: Polynucleotide capture materials, and methods of using same. Handylab, Knobbe Martens Olson & Bear, December 4, 2012: US08324372 (51 worldwide citation)

Methods for processing polynucleotide-containing biological samples, and materials for capturing polynucleotide molecules such as RNA and/or DNA from such samples. The RNA and/or DNA is captured by polyamidoamine (PAMAM(Generation 0)) bound to a surface, such as the surface of magnetic particles. Th ...


6
Kalyan Handique, Karthik Ganesan, Sundaresh N Brahmasandra: Methods and systems for control of microfluidic devices. Handylab, Knobbe Martens Olson & Bear, June 25, 2013: US08473104 (47 worldwide citation)

The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined configurations. Such microfluidic devices are preferably constructed in a hierarchical and modular fashion wh ...


7
Betty Wu, John S Althaus, Nikhil Phadke, Sundaresh N Brahmasandra, Kalyan Handique, Aaron Kehrer, Gene Parunak, Cecelia Haley, Ted Springer: Method for processing polynucleotide-containing samples. HandyLab, Knobbe Martens Olson & Bear, October 7, 2014: US08852862 (30 worldwide citation)

Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that retain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under ...


8
Kalyan Handique, Karthik Ganesan, Sundaresh N Brahmasandra: Methods and systems for control of general purpose microfluidic devices. HandyLab, Knobbe Martens Olson & Bear, November 25, 2014: US08895311 (30 worldwide citation)

The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined configurations. Such microfluidic devices are preferably constructed in a hierarchical and modular fashion wh ...


9
Kalyan Handique, Karthik Ganesan, Sundaresh N Brahmasandra: Methods and systems for control of microfluidic devices. Handylab, Knobbe Martens Olson & Bear, July 26, 2011: US07987022 (27 worldwide citation)

The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined configurations. Such microfluidic devices are preferably constructed in a hierarchical and modular fashion wh ...


10
Sundaresh N Brahmasandra, Elizabeth Craig: Polynucleotide capture materials, and methods of using same. Handylab, Knobbe Martens Olson & Bear, April 29, 2014: US08710211 (26 worldwide citation)

Methods for processing polynucleotide-containing biological samples, and materials for capturing polynucleotide molecules such as RNA and/or DNA from such samples. The RNA and/or DNA is captured by polyamindoamine (PAMAM (Generation 0)) bound to a surface, such as the surface of magnetic particles. ...