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Sugimoto Hachiro, Tsuchiya Yutaka, Higurashi Kunizou, Karibe Norio, Iimura Yuoichi, Sasaki Atsushi, Yamanashi Yoshiharu, Ogura Hiroo, Araki Shin Kashiwa Mansion, Kosasa Takashi, Kusota Atsuhiki, Kozasa Michiko, Yamatsu Kiyomi: Cyclic amine compound, its use and pharmaceutical compositions comprising it.. Eisai, December 28, 1988: EP0296560-A2 (141 worldwide citation)

A cyclic amine compound is defined by the formula: in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl, -CO-(CHR22)r-, =(CH-CH=CH)b-, =CH-( ...


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Takahashi Tohru, Sugimoto Hachiro: Quinazoline compounds. Eisai, Woodhams Blanchard and Flynn, November 18, 1975: US3920636 (60 worldwide citation)

2-(4'-SUBSTITUTED HOMOPIPERAZINO)-4-AMINO-6,7-DIMETHOXY-QUINAZOLINES HAVING THE FOLLOWING CHEMICAL FORMULA (I): v,2/14Wherein A represents a group selected from the following (i) and (ii):(i) R.sup.1 --CO--:wherein R.sup.1 represents a lower alkyl group of C.sub.1 -C.sub.4 ; phenyl group substituted ...


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Sugimoto Hachiro, Nakamura Takaharu, Karibe Norio, Saito Isao, Higurashi Kunizo, Yonaga Masahiro, Kaneko Takeru, Nakazawa Takahiro, Ueno Masataka, Yamatsu Kiyomi: Cyclic amine derivatives.. Eisai, November 2, 1988: EP0288563-A1 (35 worldwide citation)

Heterocyclic amines of formula (I) and their salts are new: where A is (opt. substd.) phenyl or naphthyl, pyridyl, thienyl, tetralyl, quinolinyl, benzofuranyl, quinazolinyl, benzothienyl, 1,2,3,4-tetrahydro-2-quinolinyl or 1-oxo-1,2,3,4-tetrahydro -2-naphthyl; X is -CH2, -CO-, -CHOH-, -CHMe- or -CH( ...


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Sugimoto Hachiro, Yonaga Masahiro, Karibe Norio, Iimura Youichi, Nagato Satoshi, Sasaki Atsushi, Yamanishi Yoshiharu, Ogura Hiroo, Kosasa Takashi, Uchikoshi Kumi, Yamatsu Kiyomi: Cyclic amide derivatives.. Eisai, January 29, 1992: EP0468187-A2 (18 worldwide citation)

The cyclic amide derivative is defined by the formula (I) or a salt thereof: R1-(CH2)n-Z in which R1 is a group derived from a cyclic amide compound, substituted or unsubstituted, n is zero or an integer of 1 to 10 and Z is R2 being an aryl, a substituted aryl, a cycloalkyl or a heterocyclic group, ...


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Sugimoto Hachiro, Tsuchiya Yutaka, Higurashi Kunizou, Karibe Norio, Iimura Youichi, Sasaki Atsushi, Yamanishi Yoshiharu, Ogura Hiroo, Araki Shin, Kosasa Takashi, Kusota Atsuhiko, Kososa Michiko, Yamatsu Kiyomi: 2-(indan-1-one-2-yl-alkyl)-1-phenylalkyl-piperidines and processes for their preparation. Eisai, November 13, 1996: EP0742207-A1 (18 worldwide citation)

Processes are provided for preparing cyclic amine compounds defined within the formula: in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl ...


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Sugimoto Hachiro, Tsuchiya Yutaka, Higurashi Kunizou, Karibe Norio, Iimura Youichi, Sasaki Atsushi, Yamanishi Yoshiharu, Ogura Hiroo, Araki Shin, Kosasa Takashi, Kusota Atsuhiko, Kozasa Michiko, Yamatsu Kiyomi: 4-[2-indanyl-1-one]alkylpiperidines as anticholinergic agents.. Eisai, September 27, 1995: EP0673927-A1 (17 worldwide citation)

A cyclic amine compound is defined by the formula: in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl, -CO-(CHR22)r-, =(CH-CH=CH)b-, =CH-( ...


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Sugimoto Hachiro, Higurashi Kunizo, Shoji Tadao, Adachi Hideyuki, Daiku Yoshiharu: 1,4-dihydropyiridine derivative, a process for preparing the same, a pharmaceutical composition as well as the use thereof.. Eisai, October 15, 1986: EP0197488-A2 (14 worldwide citation)

A novel 1,4-dihydropyridine derivative is disclosed having the formula: This derivative and pharmacologically acceptable salts thereof are effective for the treatment and prevention of cardiopathy and antihypertensive and coronary vasodilating action. There is also described a process for the prepar ...


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Sugimoto Hachiro, Tsuchiya Yutaka, Higurashi Kunizou, Karibe Norio, Iimura Youichi, Sasaki Atsushi, Yamanishi Yoshiharu, Ogura Hiroo, Araki Shin, Kosasa Takashi, Kusota Atsuhiko, Kozasa Michiko, Yamatsu Kiyomi: 1,4-substituted piperidines as acetylchozinesterase inhibitors and their use for the treatment of alzheimers disease.. Eisai, January 19, 1994: EP0579263-A1 (10 worldwide citation)

Cyclic amines of formula (I) and their salts are new. J = phenyl, pyridyl, pyrazyl, quinolyl, cyclohexyl, quinoxalyl or furyl (all opt. substd.), a monovalent gp. derived from a cyclic amide cpd., lower alkyl, or -CH=CH-R21; R21 = H or lower alkoxycarbonyl; B = (CHR22)r, CO(CHR22)r, NR4-(CHR22)r, CO ...


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Tsuchiya Yutaka, Sasaki Atsushi, Yoshino Hiroshi, Karibe Norio, Sugimoto Hachiro, Kubota Atsuhiko, Kosasa Michiko, Araki Shin, Ikeda Masuhiro, Yamanishi Yoshiharu, Machida Ryoichi, Yamatsu Kiyomi: Polypeptides, methods for their preparation, pharmaceutical compositions comprising them and use.. Eisai, September 20, 1989: EP0333071-A2 (10 worldwide citation)

A polypeptide is shown with the following formula: A-B-C-D-E-F-R wherein A, B, C, D, E, F and R are as defined in claim 1. The invention includes pharmaceutical compositions comprising the above polypeptide and the use of this polypeptide. Finally, preparation methods for the new polypeptide are dis ...