1
Raju Kucherlapati, Aya Jakobovits, Sue Klapholz, Daniel G Brenner, Daniel J Capon: Human antibodies derived from immunized xenomice. Abgenix, James F Haley Jr, Jane T Gunnison, Fish & Neave, June 13, 2000: US06075181 (548 worldwide citation)

Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipula ...


2
Raju Kucherlapati, Aya Jakobovits, Daniel G Brenner, Daniel J Capon, Sue Klapholz: Human antibodies derived from immunized xenomice. Abgenix, James F Haley Jr, Jane T Gunnison, Fish & Neave, November 21, 2000: US06150584 (441 worldwide citation)

Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed ...


3
Raju Kucherlapati, Aya Jakobovits, Sue Klapholz, Daniel G Brenner, Daniel J Capon: Generation of Xenogenetic antibodies. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, December 19, 2000: US06162963 (291 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


4
Raju Kucherlapati, Aya Jakobovits, Sue Klapholz, Daniel G Brenner, Daniel J Capon: Generation of xenogeneic antibodies. Abgenix, James F Haley Jr, Jane T Gunnison, Fish & Neave, January 6, 2004: US06673986 (131 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


5
Raju Kucherlapati, Aya Jakobovits, Daniel G Brenner, Daniel J Capon, Sue Klapholz: Human antibodies derived from immunized xenomice. March 30, 2004: US06713610 (75 worldwide citation)

Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed ...


6
Raju Kucherlapati, Aya Jakobovits, Sue Klapholz, Daniel G Brenner, Daniel J Capon: Human antibodies derived from immunized xenomice. Abgenix, James F Haley Jr, Jane T Gunnison, Fish & Neave, December 2, 2003: US06657103 (51 worldwide citation)

Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipula ...


7
Stephen Sherwin, Sue Klapholz, Arthur Skoultchi: Gene manipulation and expression using genomic elements. Cell Genesys, Pennie & Edmonds, November 26, 1996: US05578461 (41 worldwide citation)

Expression of mammalian target genes is achieved by employing chromosomal target DNA, either native primary cells or YACs in a yeast host, where the YACs include a fragment of a mammalian chromosome, the fragment comprising the target gene. Employing homologous recombination, an amplifiable gene is ...


8
Patrick Brown, Stanley Nelson, Sue Klapholz: Genomic mismatch scanning. The Board of Trustees of the Leland Stanford Junior University, Bertram I Rowland, Pamela J Sherwood, December 27, 1994: US05376526 (17 worldwide citation)

Genetic mapping is provided by combinations of two related general procedures. In the first procedure, mapping is provided by identifying genetic regions from which DNA fragments derived from two individuals can combine to form extensive hybrids free of base mismatches. DNA is processed by a method ...


9
Stephen Sherwin, Sue Klapholz, Arthur Skoultchi: Gene manipulation and expression using genomic elements. Cell Genesys, Pennie & Edmonds, January 18, 2000: US06015708 (1 worldwide citation)

Expression of mammalian target genes is achieved by employing chromosomal target DNA, either native primary cells or YACs in a yeast host, where the YACs include a fragment of a mammalian chromosome, the fragment comprising the target gene. Employing homologous recombination, an amplifiable gene is ...


10
Aya Jakobovits, Raju Kucherlapati, Sue Klapholz, Michael J Mendez, Larry Green: regions and antibodies produced therefrom, and V, Transgenic mammals having human IG loci including plural V. Amgen Fremont, Ropes & Gray, Jane T Gunnison, Raymond M Doss, October 26, 2010: US07820877

The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and Vκ) gene regions. Advantageously, the inclusion of plural va ...