1
James Benjamin Eckenhoff, Neil Arthur Johnson, Su Il Yum: Osmotically driven fluid dispenser. Alza Corporation, Thomas E Ciotti, Paul L Sabatine, Edward L Mandell, October 26, 1976: US03987790 (225 worldwide citation)

An osmotically driven fluid dispenser that is capable of being miniaturized and used as an implant to administer fluid drug compositions to animals and humans. The dispenser comprises a flexible inner bag adapted to contain the drug composition, a fluid tight plug fitted into the bag opening, a port ...


2
Richard G Buckles, Harold M Leeper, Su Il Yum, Alan S Michaels: Liquid delivery device bladder. Alza Corporation, Thomas E Ciotti, Paul L Sabatine, Edward L Mandell, November 23, 1976: US03993069 (185 worldwide citation)

An improvement in liquid dispensers, especially those used to infuse liquid drugs into patients from an expansible elastomeric bladder of specific geometry and elastomeric properties, is disclosed. The improvement is in making the bladder from an elastomeric composition whose stress relaxation does ...


3
Jessica A Warring, David B Swedlow, Michael J N Cormier, Su Il Yum, Lina T Taskovich, Albert Ollerdessen: Methods and devices for facilitated non-invasive oxygen monitoring. ALZA Corporation, Alisa A Harbin, Steven F Stone, Edward L Mandell, April 4, 1995: US05402777 (134 worldwide citation)

The present invention is directed to a sensor system for use with a blood characteristic measurement device such as a pulse oximeter, on areas of the body having low normal cutaneous blood flow and for monitoring a blood characteristic such as oxygen saturation and pulse rate of patients, preferably ...


4
Randolph Mellus Johnson, Felix Theeuwes, Edward M Gillis, Dana Litmanovitz, Barbara Laidlaw, James Brown, John Culwell, James A Filice, Peter Wickman, Su Il Yum, Andrew Poutiatine, John Dinka: Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners. Durect Corporation, Carol L Francis, Tom McCracken, Bozicevic Field & Francis, December 28, 2004: US06835194 (75 worldwide citation)

The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at lea ...


5
Eun Soo Lee, Scott A Bura, Su Il Yum, Patrick S L Wong, Felix Theeuwes: Osmotic drug delivery devices with hydrophobic wall materials. ALZA Corporation, Steven F Stone, Mary Ann Dillahunty, August 18, 1998: US05795591 (74 worldwide citation)

Osmotically driven drug delivery devices with walls of porous hydrophobic material as the sole diffusion-limiting wall component are disclosed. Despite pores which are considerably larger than the molecular dimensions of osmotically active species in the interior of the device, despite pores which b ...


6
Eun S Lee, Su Il Yum: Permeation enhancer comprising ethanol and monoglycerides. Alza Corporation, Alisa A Harbin, Edward L Mandell, Steven F Stone, January 3, 1995: US05378730 (66 worldwide citation)

Mixtures of ethanol and monoglyceride are disclosed for enhancing the permeation of drugs through skin or mucosa. The monoglyceride is a monoglyceride or a mixture of monoglycerides of fatty acids with a total monoesters content of at least about 90%. Water is also included in the permeation-enhanci ...


7
Eun Soo Lee, Felix Theeuwes, Patrick Wong S L, Su Il Yum, Alejandro Zaffaroni: Delayed onset transdermal delivery device. Alza Corporation, Jacqueline S Larson, Edward L Mandell, Steven F Stone, August 25, 1992: US05141750 (65 worldwide citation)

A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is rel ...


8
Eun Soo Lee, Su Il Yum: Skin permeation enhancer compositions using acyl lactylates. Alza Corporation, Michael J Rafa, Paul Sabatine, Steven F Stone, March 16, 1999: US05882676 (64 worldwide citation)

The present invention is directed to the transdermal administration of a drug together with a suitable amount of an acyl lactylate permeation enhancer. The invention includes a transdermal drug delivery device comprising a matrix adapted to be placed in drug- and- permeation enhancer-transmitting re ...


9
Felix Theeuwes, Su Il Yum: Osmotically driven syringe with programmable agent delivery. Jean Marie Duvall, Steven F Stone, Edward L Mandell, May 17, 1994: US05312389 (62 worldwide citation)

An osmotically driven syringe (20, 60) is disclosed which can be used to deliver a beneficial agent such as a drug, at varying pre-determined rates over multiple periods of time. The syringe (20, 60) is driven by an osmotic engine (10) having a shaped wall (12) containing an osmotic agent (17) and/o ...


10
Richard G Buckles, Seymour Hoff, Sharon Kehr, Su Il Yum: Cartridge for liquid infusion apparatus. Alza Corporation, Thomas E Ciotti, Paul L Sabatine, Edward L Mandell, February 20, 1979: US04140117 (61 worldwide citation)

A removable cartridge that is used in combination with a liquid drug infusion apparatus that comprises a housing that defines an inlet and outlet and has a recess for receiving the cartridge, a confined flow passageway extending between the inlet and outlet, and a conduit extending from the outlet t ...