1
Steven R Little, David M Lynn, Daniel G Anderson, Robert S Langer: pH triggerable polymeric particles. Massachusetts Institute of Technology, Wolf Greenfield & Sacks P C, C Hunter Baker, May 17, 2011: US07943179 (1 worldwide citation)

A drug delivery system comprising pH triggerable particles is described. The pH triggerable particles comprise and agent(s) to be delivered, which is encapsulated in a matrix comprising a pH trigger agent and a polymer. Agents including nucleic acids may be delivered intracellularly using the invent ...


2
Steven R Little: Artificial cell constructs for cellular manipulation. University of Pittsburgh Of the Commonwealth System of Higher Education, Massachusets Institute of Technology, Medlen & Carroll, September 30, 2014: US08846098

The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive agents which can increase the risk of infection, autoimmunity, and cancer. Immunological tolerance is th ...


3
Steven R Little, Kaladhar Kamalasanan: Methods to prepare patchy microparticles. University of Pittsburgh of the Commonwealth System of Higher Education, Klarquist Sparkman, December 15, 2015: US09211519

A method for making microparticles having an exterior surface that includes preparing a self-assembled arrangement of microparticles; contacting the self-assembled microparticles with a patch-forming agent resulting in a microparticle/patch-forming agent assembly having proximal regions between adja ...


4
Riccardo Gottardi, Peter Alexander, Patrick A Bianconi, Steven R Little: Treating soft tissue via controlled drug release. University of Pittsburgh—Of the Commonwealth System of Higher Education, Klarquist Sparkman, January 15, 2019: US10179111

Methods for inhibiting tissue ossification or calcification in a subject, comprising administering a therapeutically effective amount of BMP I inhibitor-loaded microparticles to a subject in need thereof, wherein the administration provides local and sustained release of the BMP I inhibitor thereby ...


5
Steven R Little, David M Lynn, Daniel G Anderson, Robert S Langer: pH triggerable polymeric particles. Choate Hall & Stewart, November 3, 2005: US20050244504-A1

A drug delivery system comprising pH triggerable particles is described. The pH triggerable particles comprise and agent(s) to be delivered, which is encapsulated in a matrix comprising a pH trigger agent and a polymer. Agents including nucleic acids may be delivered intracellularly using the invent ...


6
Jorg C Gerlach, Jianjun Guan, Steven R Little, Alan J Russell, Jillian Tengood, William R Wagner: Triggerably dissolvable hollow fibers for controlled delivery. Jesse A Hirshman Esq, May 28, 2009: US20090136553-A1

Provided are tubular structures of a biocompatible, triggerably-dissolvable material such as cellulose or a copolymer having an LCST below physiological temperatures. The structures may be embedded within a cell growth scaffold. The tubular structures are useful in growing 3-dimensional tissue struc ...


7
Steven R Little: Artificial cell constructs for cellular manipulation. June 14, 2012: US20120148676-A1

The present invention contemplates induction of immunological tolerance thereby providing permanent allogcaft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive agents which can increase the risk of infection, autoimmunity, and cancer. Immunological tolerance is th ...


8
Steven R Little, Kaladhar Kamalasanan: Methods to prepare patchy microparticles. August 23, 2012: US20120214001-A1

A method for making microparticles having an exterior surface that includes preparing a self-assembled arrangement of microparticles; contacting the self-assembled microparticles with a patch-forming agent resulting in a microparticle/patch-forming agent assembly having proximal regions between adja ...


9
Steven R Little, Sam Rothstein: Engineered microparticles for macromolecule delivery. July 5, 2012: US20120172456-A1

A method for making a modified release composition, comprising: selecting a desired active agent and polymer matrix for formulating into a modified release composition;assessing degradation effect on release of the active agent from the composition including plotting polymer molecular weight (Mwr) a ...