1
Craig A Rosen, Steven M Ruben: Human secreted proteins. Human Genome Sciences, May 6, 2008: US07368531 (131 worldwide citation)

The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding the polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to the human secreted proteins. Antibodies that bind these polypeptides are also encompassed ...


2
Craig A Rosen, William A Haseltine, David J Ballance, Andrew J Turner, Steven M Ruben: Albumin fusion proteins comprising GLP-1 polypeptides. Human Genome Sciences, Finnegan Henderson Farabow Garrett & Dunner, November 28, 2006: US07141547 (91 worldwide citation)

The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making ...


3
Craig A Rosen, Steven M Ruben: Antibodies to HDPPA04 polypeptide. Human Genome Sciences, Foley & Lardner, August 12, 2008: US07411051 (84 worldwide citation)

The present invention relates to antibodies that specifically bind HDPPA04 polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said HDPPA04. Also encompassed by the invention are host cells and hybridomas for producing said antibodies. The invention fur ...


4
Craig A Rosen, Vivian R Albert, Steven M Ruben, Ruth E Wager: Antibodies to vascular endothelial growth factor 2 (VEGF-2). Human Genome Sciences, Sterne Kessler Goldstein & Fox P L L C, July 22, 2008: US07402312 (69 worldwide citation)

Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention also relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an anim ...


5
Theodora W Salcedo, Steven M Ruben, Craig A Rosen, Vivian R Albert, Claire Dobson, Tristan Vaughan: Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors. Human Genome Sciences, March 25, 2008: US07348003 (62 worldwide citation)

The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding a ...


6
Theodora W Salcedo, Steven M Ruben, Craig A Rosen, Vivian R Albert, Claire Dobson, Tristan Vaughan: Methods of treating cancer using antibodies that immunospecifically bind to trail receptors. Human Genome Sciences, April 22, 2008: US07361341 (61 worldwide citation)

The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibod ...


7
Steven M Ruben, Gil H Choi, Tristan Vaughan, David Hilbert: Antibodies that immunospecifically bind BLyS. Human Genome Sciences, Human Genome Sciences, November 21, 2006: US07138501 (47 worldwide citation)

The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or i ...


8
Yi Li, Steven M Ruben: Polynucleotides encoding human G-protein chemokine receptor HDGNR10. Human Genome Sciences, Sterne Kessler Goldstein & Fox P L L C, February 15, 2000: US06025154 (47 worldwide citation)

Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides an ...


9
Steven M Ruben: Antibodies against tumor necrosis factor delta (APRIL). Human Genome Sciences, Human Genome Sciences, March 13, 2007: US07189820 (42 worldwide citation)

The present invention relates to antibodies and related molecules that immunospecifically bind to Tumor Necrosis Factor Delta (TNF-delta; APRIL). The present invention also relates to methods and compositions for detecting, diagnosing, prognosing, treating, preventing, or ameliorating a disease or d ...


10
Craig A Rosen, Steven M Ruben, Paul A Moore: Antibodies to HSDEK49 polypeptides. Human Genome Sciences, June 28, 2011: US07968689 (41 worldwide citation)

The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating immune disorders and diseases. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by t ...