1
Ronald W Barrett, Michael C Pirrung, Lubert Stryer, Christopher P Holmes, Steven A Sundberg: Spatially-addressable immobilization of anti-ligands on surfaces. Affymax Technologies, Kevin R Kaster, Jeffrey K Weaver, Karen B Dow, October 12, 1993: US05252743 (295 worldwide citation)

Methods and compositions are described for immobilizing anti-ligands, such as antibodies or antigens, hormones or hormone receptors, oligonucleotides, and polysaccharides on surfaces of solid substrates for various uses. The methods provide surfaces covered with caged binding members which comprise ...


2
Steven A Sundberg, David Fujimoto: Derivatization of solid supports and methods for oligomer synthesis. Affymax Technologies, Townsend and Townsend and Crew, April 29, 1997: US05624711 (256 worldwide citation)

Methods and derivatized supports which are useful in solid-phase synthesis of peptides, oligonucleotides or other small organic molecules as well as arrays of ligands. The methods provide means to control the functional site density on a solid support. Some of the derivatized supports are polymer-co ...


3
Ronald W Barrett, Michael C Pirrung, Lubert Stryer, Christopher P Holmes, Steven A Sundberg: Spatially-addressable immobilization of anti-ligands on surfaces. Affymax Technologies, Lauren L Stevens, September 19, 1995: US05451683 (185 worldwide citation)

Methods and compositions are described for immobilizing anti-ligands, such as antibodies or antigens, hormones or hormone receptors, oligonucleotides, and polysaccharides on surfaces of solid substrates for various uses. The methods provide surfaces covered with caged binding members which comprise ...


4
Joseph E Kercso, Steven A Sundberg, Jeffrey A Wolk, Andrew W Toth, Calvin Y H Chow, J Wallace Parce: High throughput microfluidic systems and methods. Caliper Technologies Corporation, Mark D Barrish Esq, Townsend Townsend & Crew, October 17, 2000: US06132685 (164 worldwide citation)

The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multiwell microtiter plates or other array structures. The multiwell plates travel along a conveyor system to a test station having a microfluidic device. At the test ...


5
Steven A Sundberg, J Wallace Parce, Calvin Y H Chow: Microfabricated structures for facilitating fluid introduction into microfluidic devices. Caliper Technologies, Mark D Barrish Esq, Townsend Townsend & Crew, July 18, 2000: US06090251 (164 worldwide citation)

Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out ...


6
Steven A Sundberg, Jeffrey W Jacobs, John R Schullek, Glenn H McGall, Andrei Mirzabekov, Edward Timofeey, David Fujimoto, Christopher P Holmes, Hua Yang: Derivatization of solid supports and methods for oligomer synthesis. Affymetrix, Townsend & Townsend & Crew, July 6, 1999: US05919523 (160 worldwide citation)

Methods and derivatized supports which are useful in solid-phase synthesis of peptides, oligonucleotides or other small organic molecules as well as arrays of ligands. The methods provide means to control the functional site density on a solid support. Some of the derivatized supports are polymer-co ...


7
Ronald W Barrett, Michael C Pirrung, Lubert Stryer, Christopher P Holmes, Steven A Sundberg: Spatially-addressable immobilization of anti-ligands on surfaces. Affymax Technologies, Kevin R Kaster, Tracy J Dunn, Lauren L Stevens, January 9, 1996: US05482867 (150 worldwide citation)

Methods and compositions are described for immobilizing anti-ligands, such as antibodies or antigens, hormones or hormone receptors, oligonucleotides, and polysaccharides on surfaces of solid substrates for various uses. The methods provide surfaces covered with caged binding members which comprise ...


8
Andrea W Chow, Robert S Dubrow, J Wallace Parce, Steven A Sundberg, Jeffrey A Wolk: External material accession systems and methods. Caliper Technologies, Matthew B Murphy, November 21, 2000: US06149787 (144 worldwide citation)

Methods, apparatus and systems are provided for introducing large numbers of different materials into a microfluidic analytical device rapidly, efficiently and reproducibly. In particular, improved integrated pipettor chip configurations, e.g. sippers or electropipettors, are described which are cap ...


9
Anne R Kopf Sill, Steven A Sundberg, Andrea W Chow, Claudia L Poglitsch: Dilutions in high throughput systems with a single vacuum source. Caliper Life Sciences, Donald R McKenna, February 22, 2005: US06858185 (135 worldwide citation)

Flow rates in a microfluidic device are modulated after performing serial dilutions by flow reduction channels that draw fluid from the main channel, thus reducing the flow rate. The reduction in flow rate and/or use of smaller dimension channels allow reduced reagent consumption. In addition, multi ...


10
Andrea W Chow, Anne R Kopf Sill, J Wallace Parce, Steven A Sundberg: Microfluidic devices, systems and methods for performing integrated reactions and separations. Caliper Technologies, Matthew B Murphy, August 14, 2001: US06274089 (133 worldwide citation)

Microfluidic devices for performing integrated reaction and separation operations. The devices include a planar substrate having a first surface with an integrated channel network disposed therein. The reaction region in the integrated microscale channel network has a mixture of at least first and s ...