1
Nathan B Mantlo, Stephen T Schlachter, John A Josey: Substituted pyridine compounds and methods of use. Amgen, Steve Odre, Ron Levy, Frank Ungemach, February 8, 2000: US06022884 (85 worldwide citation)

Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-.alpha., IL-1.beta., IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically ...


2
James Halbrook, Edward A Kesicki, Laurence E Burgess, Stephen T Schlachter, Charles T Eary, Justin G Schiro, Hongmei Huang, Michael Evans, Yongxin Han: Materials and methods to potentiate cancer treatment. ICOS Corporation, Wolf Greenfield & Sacks P C, February 20, 2007: US07179912 (34 worldwide citation)

Compounds that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods to inhibit the DNA-PK biological activity, methods to sensitize cells the agents that cause DNA lesions, and methods to potentiate cancer treatment are disclosed.


3
Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Birong Zhang, Christine Chabot, Steven Do: Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Covenentech, Viksnins Harris & Padys PLLP, November 22, 2011: US08063050 (25 worldwide citation)

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatmen ...


4
Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Jun Li, Christine Chabot: Pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Genertech, Viksnins Harris & Padys PLLP, August 23, 2011: US08003651 (22 worldwide citation)

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for ...


5
Nathan B Mantlo, Stephen T Schlachter, John A Josey: Substituted pyridine compounds and methods of use. Amgen, Frank S Ungemach, Stuart L Watt, December 25, 2001: US06333341 (22 worldwide citation)

Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically ac ...


6
Timothy J Martins, Kerry W Fowler, Joshua Odingo, Edward A Kesicki, Amy Oliver, Laurence E Burgess, John J Gaudino, Zachary S Jones, Bradley J Newhouse, Stephen T Schlachter: Cyclic AMP-specific phosphodiesterase inhibitors. ICOS Corporation, Marshall Gerstein & Borun, July 23, 2002: US06423710 (14 worldwide citation)

Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disord ...


7
Nathan B Mantlo, Stephen T Schlachter, John A Josey: Substituted pyridine compounds and methods of use. Amgen, Richard V Person, Frank S Ungemach, Steven M Odre, October 1, 2002: US06458813 (13 worldwide citation)

Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically ac ...


8
Richard A Nugent, Stephen T Schlachter: Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories. The Upjohn Company, Donald Corneglio, March 14, 1995: US05397774 (12 worldwide citation)

Compounds useful in the treatment of inflammation structurally represented as ##STR1## wherein X is O or S and the R groups are as herein defined. The compounds are useful as anti-inflammatory and anti-arthritic agents without inhibiting prostaglandin synthesis.


9
Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Birong Zhang, Christine Chabot, Steven Do: Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array Biopharma, Genentech, Viksnins Harris & Padys PLLP, October 7, 2014: US08853199 (7 worldwide citation)

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatmen ...


10
Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Jun Li, Christine Chabot: Pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Genentech, Viksnins Harris & Padys PLLP, September 30, 2014: US08846681 (7 worldwide citation)

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for ...



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