1
Michael C Pirrung, J Leighton Read, Stephen P A Fodor, Lubert Stryer: Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof. Affymax Technologies, Kenneth J Nussbacher, Kevin R Kaster, Vern Norviel, September 1, 1992: US05143854 (1323 worldwide citation)

Polypeptide arrays can be synthesized on a substrate by attaching photoremovable groups to the surface of a substrate, exposing selected regions of the substrate to light to activate those regions, attaching an amino acid monomer with a photoremovable group to the activated regions, and repeating th ...


2
Stephen P A Fodor, Lubert Stryer, J Leighton Read, Michael C Pirrung: Arrays of materials attached to a substrate. Affymetrix, Vern Norviel, Nancy J DeSantis, Joseph Liebeschuetz, April 28, 1998: US05744305 (827 worldwide citation)

A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reacto ...


3
Stephen P A Fodor, Michael C Pirrung, J Leighton Read, Lubert Stryer: Array of oligonucleotides on a solid substrate. Affymax Technologies, Townsend and Townsend Khourie and Crew, August 29, 1995: US05445934 (825 worldwide citation)

A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, i ...


4
Robert J Lipshutz, Richard P Rava, Rolfe C Anderson, Stephen P A Fodor: Integrated nucleic acid diagnostic device. Affymetrix, Townsend and Townsend and Crew, January 5, 1999: US05856174 (635 worldwide citation)

The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the d ...


5
Rolfe C Anderson, Robert J Lipshutz, Richard P Rava, Stephen P A Fodor: Integrated nucleic acid diagnostic device. Affymetrix, Townsend & Townsend & Crew, July 13, 1999: US05922591 (597 worldwide citation)

The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the d ...


6
Stephen P A Fodor, Dennis W Solas, William J Dower: Method of detecting nucleic acids. September 1, 1998: US05800992 (518 worldwide citation)

The present invention provides method and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and ...


7
Stephen P A Fodor, Lubert Stryer, Michael C Pirrung, J Leighton Read: Very large scale immobilized polymer synthesis. Affymax Technologies, Kevin R Kaster, Vern Norviel, June 13, 1995: US05424186 (505 worldwide citation)

A method for synthesizing oligonucleotides on a solid substrate. The method provides for the irradiation of a first predefined region of the substrate without irradiation of a first predefined region of the substrate. The irradiation of a second predefined region of the substrate. The irradiation st ...


8
Mark Trulson, David Stern, Peter Fiekowsky, Richard Rava, Ian Walton, Stephen P A Fodor: Method and apparatus for imaging a sample on a device. Affymetrix, Townsend & Townsend & Crew, November 26, 1996: US05578832 (426 worldwide citation)

The present invention provides methods and systems for detecting a labeled marker on a sample located on a support. The imaging system comprises a body for immobilizing the support, an excitation radiation source and excitation optics to generate and direct the excitation radiation at the sample. In ...


9
Mark Chee, Maureen T Cronin, Stephen P A Fodor, Xiaohua X Huang, Earl A Hubbell, Robert J Lipshutz, Peter E Lobban, MacDonald S Morris, Edward L Sheldon: Arrays of nucleic acid probes on biological chips. Affymetrix, Townsend & Townsend & Crew, November 17, 1998: US05837832 (418 worldwide citation)

DNA chips containing arrays of oligonucleotide probes can be used to determine whether a target nucleic acid has a nucleotide sequence identical to or different from a specific reference sequence. The array of probes comprises probes exactly complementary to the reference sequence, as well as probes ...


10
Rolfe C Anderson, Robert J Lipshutz, Richard P Rava, Stephen P A Fodor: Miniaturized genetic analysis systems and methods. Affymetrix, Townsend and Townsend and Crew, January 2, 2001: US06168948 (406 worldwide citation)

The present invention provides a miniaturized integrated nucleic acid diagnostic device and system which includes a nucleic acid extraction zone including nucleic acid binding sites.



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