1
Stephen L Monfre, Kevin H Hazen, Timothy L Ruchti, Thomas B Blank, James R Henderson: Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers. Sensys Medical, Michael A Glenn, Glenn Patent Group, February 14, 2006: US06998247 (648 worldwide citation)

Methods for calibrating noninvasive or implantable glucose analyzers utilize either alternative invasive glucose determinations or noninvasive glucose determinations for calibrating noninvasive or implantable glucose analyzers. Use of an alternative invasive or noninvasive glucose determination in t ...


2
George M Acosta, James R Henderson, N Alan Abul Haj, Timothy L Ruchti, Stephen L Monfre, Thomas B Blank, Kevin H Hazen: Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy. Sensys Medical, Michael A Glenn, Glenn Patent Group, November 7, 2006: US07133710 (332 worldwide citation)

The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological paramete ...


3
Stephen L Monfre, Kevin H Hazen, Timothy L Ruchti, Thomas B Blank, James R Henderson: Apparatus using reference measurement for calibration. Sensys Medical, Michael A Glenn, Glenn Patent Group, February 27, 2007: US07183102 (287 worldwide citation)

A method and apparatus for calibrating noninvasive or implantable glucose analyzers that uses either alternative invasive glucose determinations or noninvasive glucose determinations to calibrate noninvasive or implantable glucose analyzers. Use of an alternative invasive or noninvasive glucose dete ...


4
George Acosta, James R Henderson, N Alan Abul Haj, Timothy L Ruchti, Stephen L Monfre, Thomas B Blank, Kevin H Hazen: Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy. Sensys Medical, Michael A Glenn, Glenn Patent Group, November 20, 2007: US07299080 (221 worldwide citation)

A near IR spectrometer-based analyzer attaches continuously or semi-continuously to a human subject and collects spectral measurements for determining a biological parameter in the sampled tissue, such as glucose concentration. The analyzer includes an optical system optimized to target the cutaneou ...


5
Thomas B Blank, George Acosta, Mutua Mattu, Marcy Makarewicz, Stephen L Monfre, Alexander D Lorenz, Timothy L Ruchti: Optical sampling interface system for in vivo measurement of tissue. Sensys Medical, Michael A Glenn, Glenn Patent Group, June 19, 2007: US07233816 (146 worldwide citation)

An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on ...


6
Thomas B Blank, Stephen L Monfre, Timothy L Ruchti, Suresh Thennadil: Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction. Sensys Medical, Michael A Glenn, Chris Peil, January 28, 2003: US06512937 (146 worldwide citation)

A method of multi-tier classification and calibration in noninvasive blood analyte prediction minimizes prediction error by limiting co-varying spectral interferents. Tissue samples are categorized based on subject demographic and instrumental skin measurements, including in vivo near-IR spectral me ...


7
Linda Hockersmith, Thomas B Blank, Stephen L Monfre, Timothy L Ruchti: Use of targeted glycemic profiles in the calibration of a noninvasive blood glucose monitor. Sensys Medical, Michael A Glenn, Christopher Peil, November 26, 2002: US06487429 (141 worldwide citation)

A method of calibrating a non-invasive blood glucose measurement instrument to a diabetic test subject employs targeted glycemic profiles in anti-correlated pairs. During calibration, reference blood glucose determinations are made using conventional invasive sampling methods. Concurrently, noninvas ...


8
Thomas B Blank, George Acosta, Mutua Mattu, Marcy Makarewicz, Stephen L Monfre, Alexander D Lorenz, Timothy L Ruchti: Optical sampling interface system for in vivo measurement of tissue. Sensys Medical, Michael A Glenn, Glenn Patent Group, April 17, 2007: US07206623 (121 worldwide citation)

An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on ...


9
Thomas B Blank, Stephen L Monfre, Kevin H Hazen, Timothy L Ruchti, Christopher Slawinski, Sedar R Brown: Method and apparatus for coupling a channeled sample probe to tissue. GLT Acquisition, Knobbe Martens Olson & Bear, August 6, 2013: US08504128 (101 worldwide citation)

Sampling is controlled in order to enhance analyte concentration estimation derived from noninvasive sampling. More particularly, sampling is controlled using controlled fluid delivery to a region between a tip of a sample probe and a tissue measurement site. The controlled fluid delivery enhances c ...


10
Stephen L Monfre, Thomas B Blank, Timothy L Ruchti, Suresh Thennadil: Multi-tier method of classifying sample spectra for non-invasive blood analyte prediction. Sensys Medical, Michael A Glenn, Chris Peil, January 28, 2003: US06512936 (84 worldwide citation)

A method of multi-tier classification and calibration in noninvasive blood analyte prediction minimizes prediction error by limiting co-varying spectral interferents. Tissue samples are categorized based on subject demographic and instrumental skin measurements, including in vivo near-IR spectral me ...