Stephen G Hoge, Antonin de Fougerolles, Jeff Lynn Ellsworth: Compositions and methods of altering cholesterol levels. Moderna Therapeutics, DT Ward PC, Donna T Ward, Jennifer F Bryan, March 17, 2015: US08980864 (9 worldwide citation)

The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules.

Tirtha Chakraborty, Stephane Bancel, Stephen G Hoge, Atanu Roy, Antonin de Fougerolles, Noubar B Afeyan: Terminally modified RNA. ModernaTx, Nelson Mullins Riley & Scarborough, Amy E Mandragouras Esq, March 21, 2017: US09597380

The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.

Stephen G Hoge, William Joseph Issa, Edward John Miracco, Jennifer Nelson, John Reynders, Matthew Stanton: Alternative nucleic acid molecules containing reduced uracil content and uses thereof. ModernaTX, Sterne Kessler Goldstein Fox, September 5, 2017: US09751925

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may ...