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Summers James B, Sheppard George S, Phillips James G, Steinman Douglas H, Guinn Denise E, Carrera George M Jr, Pireh Daisy, May Paul D, Heyman H Robin, Davidsen Steven K: Platelet activating factor antagonists.. Abbott Lab, August 26, 1992: EP0499987-A1 (5 worldwide citation)

Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic ...


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Curtin Michael L, Davidsen Steven K, Frey Robin R, Heyman Howard R, Holms James H, Michaelides Michael, Steinman Douglas H: Isoindolin-1-one compounds as kinase inhibitors. Abbott Laboratories, Curtin Michael L, Davidsen Steven K, Frey Robin R, Heyman Howard R, Holms James H, Michaelides Michael, Steinman Douglas H, STEELE Gregory, December 16, 2004: WO/2004/108672 (4 worldwide citation)

Compounds having the formula, (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds and compositions containing the compounds.


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Summers James B, Davidsen Steven K, Holms James H, Pireh Daisy, Heyman H Robin, Martin Michael B, Steinman Douglas H, Sheppard George S, Carrera George M Jr: Platelet activating factor antagonists.. Abbott Lab, May 11, 1994: EP0595924-A1

Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazoline, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including ...


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Michaelides Michael R, Mcclellan William J, Frey Robin R, Curtin Michael L, Steinman Douglas H, Dai Yujia, Holms James H: 9-membered heterobicyclic compounds as inhibitors of protein kinases. Abbott Laboratories, guanli xin lilian tao, December 31, 2008: CN200680052187

The invention discloses compounds that inhibit protein kinases, compositions containing the compounds and methods of treating cancer using the compounds.


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