1
Stanley T Crooke: Oligoribonucleotides and ribonucleases for cleaving RNA. Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, August 22, 2000: US06107094 (308 worldwide citation)

Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementa ...


2
Stanley T Crooke: Oligoribonucleotides for cleaving RNA. ISIS Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, April 27, 1999: US05898031 (254 worldwide citation)

Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementar ...


3
Stanley T Crooke, Christopher K Mirabelli, David J Ecker, Lex M Cowsert: Antisense oligonucleotide inhibition of papillomavirus. Isis Pharmaceuticals, Jane Massey Licata, October 10, 1995: US05457189 (143 worldwide citation)

Oligonucleotides are provided which are capable of antisense interaction with messenger RNA of papillomavirus. Such oligonucleotides or oligonucleotide analogs can be used for diagnostics and therapeutics as well as for research purposes. In accordance with preferred embodiments of this invention, o ...


4
Stanley T Crooke: Oligoribonucleotides and ribonucleases for cleaving RNA. Isis Pharmaceuticals, Woodcock Washburn, April 13, 2010: US07695902 (107 worldwide citation)

Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2′-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementa ...


5
Stanley T Crooke, David J Ecker, Rangarajan Sampath, Susan M Freier, Christian Massire, Steven A Hofstadler, Kristin Sannes Lowery, Eric E Swayze, Brenda F Baker, C Frank Bennett: Compositions and methods for the treatment of severe acute respiratory syndrome (SARS). Isis Pharmaceuticals, Knobbe Martens Olson and Bear, March 4, 2008: US07339051 (87 worldwide citation)

The present invention provides design and synthesis of oligomeric compounds and compositions that can be administered to reduce the activity of SARS virus in vivo or in vitro, to prevent or treat SARS virus-associated disease, to detect AARS virus, and to diagnose SARS virus-associated diseases.


6
David J Ecker, Richard H Griffey, Rangarajan Sampath, Steven A Hofstadler, John McNeil, Stanley T Crooke, Lawrence B Blyn, Thomas A Hall: Methods for rapid detection and identification of bioagents for environmental and product testing. Isis Pharmaceuticals, Medlen & Carroll, August 14, 2007: US07255992 (84 worldwide citation)

The present invention provides methods for rapid detection of bioagents for environmental and product testing. The methods can be used for testing air, water, soil, surfaces of buildings, containers, towers and the like, as well as testing of foodstuff and cosmetics.


7
Stanley T Crooke, Richard Griffey, Steve Hofstadler: Mass spectrometric methods for biomolecular screening. ISIS Pharmaceuticals, Woodcock Washburn, August 6, 2002: US06428956 (80 worldwide citation)

The present invention provides methods for the determination of the structure of biomolecular targets, as well as the site and nature of the interaction between ligands and biomolecular targets. The present invention also provides methods for the determination of the relative affinity of a ligand fo ...


8
David J Ecker, Richard H Griffey, Rangarajan Sampath, Steven A Hofstadler, John McNeil, Stanley T Crooke, James C Hannis: Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations. Isis Pharmaceuticals, Medlen & Carroll, June 5, 2007: US07226739 (79 worldwide citation)

The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.


9
Kenneth G Draper, David J Ecker, Christopher K Mirabelli, Stanley T Crooke: Antisense oligonucleotides for inhibiting herpesviruses. ISIS Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, September 28, 1993: US05248670 (79 worldwide citation)

Antisense oligonucleotides are disclosed having a length of 15-30 nucleotides containing the CAT sequence and hybridizable to herpes simplex virus type I gene UL13, UL39, or UL40. These antisense oligomers inhibit the replication of the virus at least three-fold. Pharmaceutical compositions containi ...


10
David J Ecker, Richard H Griffey, Rangarajan Sampath, Steven A Hofstadler, John McNeil, Stanley T Crooke: Methods for providing bacterial bioagent characterizing information. ISIS Pharmaceuticals, Medlen & Carroll, May 15, 2007: US07217510 (75 worldwide citation)

The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing again ...