1
Stanley N Lapidus, Philip Richard Buzby, Timothy Harris: Short cycle methods for sequencing polynucleotides. Helicos Biosciences Corporation, Thomas C Meyers Esq, Goodwin Procter, January 30, 2007: US07169560 (214 worldwide citation)

The invention provides methods for sequencing a polynucleotide comprising stopping an extension cycle in a sequence by synthesis reaction before the reaction has run to near or full completion.


2
Stanley N Lapidus, Joseph J Dziezanowski, Seymour A Friedel, Michael P Greenberg: Vision inspection system. Itran Corporation, April 8, 1986: US04581762 (161 worldwide citation)

A vision inspection system operable with foreground illumination provides user identification of selected regions of a known object for later comparison to an unknown object. A gray scale pixel array of each selected region is processed for edges and this processed data array is stored as a template ...


3
Anthony P Shuber, Stanley N Lapidus, George Q Daley: Methods for the detection of nucleic acids. Exact Science, Whitehead Institute for Biomedical Research, Testa Hurwitz & Thibeault, March 20, 2001: US06203993 (120 worldwide citation)

Methods are provided for identifying nucleic acids. Methods of the invention are useful for identifying and analyzing nucleic acids, especially variants of single nucleotide polymorphisms, that are indicative of disease or the predisposition for disease.


4
Stanley N Lapidus, Anthony P Shuber: Methods for the detection of loss of heterozygosity. Exact Laboratories, Testa Hurwitz & Thibeault, July 27, 1999: US05928870 (120 worldwide citation)

Methods are provided for detecting loss of heterozygosity in a nucleic acid sample. These methods are particularly useful for identifying individuals with gene mutations indicative of early colorectal cancer.


5
Anthony P Shuber, Stanley N Lapidus: Methods for the detection of chromosomal aberrations. Exact Laboratories, Testa Hurwitz & Thibeault, April 10, 2001: US06214558 (116 worldwide citation)

Methods are provided for detecting fetal chromosomal aberrations by detecting statistically-significant differences between normal and aberrant chromosomes.


6
Stanley N Lapidus, Anthony P Shuber, Kevin M Ulmer: Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample. Exact Laboratories, Testa Hurwitz & Thibeault, September 23, 1997: US05670325 (96 worldwide citation)

Methods are provided for detecting the presence of mutant sequences in a subpopulation of gene sequences in a biological sample. These methods are particularly useful for identifying individuals with gene mutations indicative of early colorectal cancer.


7
Stanley N Lapidus, Anthony P Shuber: Methods for disease diagnosis from stool samples. Exact Laboratories, Testa Hurwitz & Thibeault, September 14, 1999: US05952178 (76 worldwide citation)

The present invention provides methods for preparing a stool sample in order to screen for the presence of indicators of a disease, for example a subpopulation of cancerous or precancerous cells. The methods take advantage of the recognition that cellular debris from cancerous and precancerous cells ...


8
Stanley N Lapidus, Anthony P Shuber: Methods for the detection of chromosomal aberrations. Exact Laboratories, Testa Hurwitz & Thibeault, August 8, 2000: US06100029 (75 worldwide citation)

Methods are provided for detecting fetal chromosomal aberrations by detecting statistically-significant differences between normal and aberrant chromosomes.


9
Stanley N Lapidus, Anthony P Shuber: Methods for detecting differences in RNA expression levels and uses therefor. Exact Laboratories, Testa Hurwitz & Thibeault, November 14, 2000: US06146828 (59 worldwide citation)

Methods are disclosed for the detection and diagnosis of disease by determining differences in the number of RNA molecules in a patient sample compared to an expected number.


10
Anthony P Shuber, Stanley N Lapidus: Methods for the detection of nucleic acids. Exact Sciences Corporation, Testa Hurwitz & Thibeault, October 9, 2001: US06300077 (50 worldwide citation)

Methods are provided for identifying nucleic acids. Methods of the invention are useful for identifying and analyzing nucleic acids, especially variants of single nucleotide polymorphisms, that are indicative of disease or the predisposition for disease.