1
Spiridon Spireas, Sanford M Bolton: Liquisolid systems and methods of preparing same. Cohen Pontani Lieberman Pavane, September 1, 1998: US05800834 (16 worldwide citation)

Liquisolid systems are acceptably flowing and compressible powdered forms of liquid medications. According to the concept of liquisolid systems, liquid lipophilic drugs, or water-insoluble solid drugs dissolved in suitable non-volatile solvents, may be converted into free-flowing and readily compres ...


2
Spiridon Spireas, Sanford M Bolton: Liquisolid systems and methods of preparing same. Caesar Rivise Bernstein Cohen & Pokotilow, August 1, 2000: US06096337 (11 worldwide citation)

Liquisolid systems are acceptably flowing and compressible powdered forms of liquid medications. According to the concept of liquisolid systems, liduid lipophilic drugs, or water-insoluble solid drugs dissolved in suitable non-volatile solvents, may be converted into free-flowing and readily compres ...


3
Spiridon Spireas: Stable solid dosage forms of amino acids and processes for producing same. Mutual Pharmaceutical Co, Woodcock Washburn, June 6, 2006: US07056951 (9 worldwide citation)

Pharmaceutical formulations, and processes for making same, comprising an amino acid which is liable to formation of an undesirable lactam, and a stabilizer comprising a volatile alcohol; a non-volatile alcohol; a water immiscible liquid or solid; a liquid with a relatively low dielectric constant; ...


4
Spiridon Spireas, Sanford M Bolton: Liquisolid systems and methods of preparing same. Caesar Rivise Bernstein Cohen & Pokotilow, October 19, 1999: US05968550 (7 worldwide citation)

Liquisolid systems are acceptably flowing and compressible powdered forms of liquid medications. According to the concept of liquisolid systems, liquid lipophilic drugs, or water-insoluble solid drugs dissolved in suitable non-volatile solvents, may be converted into free-flowing and readily compres ...


5
Spiridon Spireas: Liquisolid systems and methods of preparing same. Caesar Rivise Bernstein Cohen & Pokotilow, July 23, 2002: US06423339 (7 worldwide citation)

A method of producing a free flowing and compressible liquid/power admixture of an active drug substance, by converting the active substance into a liquisolid system. This is accomplished by introducing by the drug into a non-volatile liquid or a mixture of non-volatile and volatile liquids to from ...


6
Spiridon Spireas: Stabilization of solid thyroid drug formulations. Mutual Pharmaceutical Co, Woodcock Washburn, February 15, 2005: US06855333 (5 worldwide citation)

Pharmaceutical formulations and dosage forms are provided having improved stability to moisture-induced degradation when compared with conventional dosage forms, especially tablets. The invention features low compression forms of thyroid drugs together with excipients, preferably in encapsulated for ...


7
Spiridon Spireas: Stabilization of solid drug formulations. Mutual Pharmaceutical Co, Woodcock Washburn, December 27, 2005: US06979462 (5 worldwide citation)

Pharmaceutical formulations and dosage forms are provided having improved stability to moisture-induced degradation when compared with conventional dosage forms, especially tablets. The invention features low compression forms of drugs known to be susceptible to moisture-induced degradation together ...


8
Spiridon Spireas: Stable formulations of ACE inhibitors, and methods for preparation thereof. Mutual Pharmaceutical Co, Woodcock Washburn, April 29, 2003: US06555551 (3 worldwide citation)

The present invention provides stable formulations of ACE inhibitors, especially enalapril maleate, that can be manufactured in a time efficient, cost effective manner. Such formulations can be prepared simply and on a large industrial scale. The present invention also provides methods for the prepa ...


9
Spiridon Spireas, Ishari Piya, Rakesh Grover, Sunil Sagi, Ram K Kallur: Highly stable compositions of orally active nucleotide analogues or orally active nucleotide analogue prodrugs. Sigmapharm Laboratories, Leydig Voit & Mayer, April 18, 2017: US09622967

Disclosed are highly stable compositions having outstanding storage stability and/or demonstrating exceptional resistance to aqueous solution degradation, the composition including an orally active nucleotide analog or an orally active nucleotide analog prodrug, which is orally bioavailable, such as ...


10
Spiridon Spireas: Stable formulations of ACE inhibitors, and methods for preparation thereof. Mutual Pharmaceutical Co, Woodcock Washburn, July 20, 2004: US06764694

The present invention provides stable formulations of ACE inhibitors, especially enalapril maleate, that can be manufactured in a time efficient, cost effective manner. Such formulations can be prepared simply and on a large industrial scale. The present invention also provides methods for the prepa ...