1
Alain Carpentier, Sophie Carpentier, Aws S Nashef: Implantable biological tissue and process for preparation thereof. American Hospital Supply Corporation, Bernard Rothwell & Brown, March 10, 1987: US04648881 (267 worldwide citation)

A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes treatment of tissue with solutions prior to implantation which have been found effective in reducing calcification o ...


2
Alain Carpentier, Sophie Carpentier, Aws S Nashef: Implantable biological tissue and process for preparation thereof. American Hospital Supply Corporation, Bernard Rothwell & Brown, March 3, 1987: US04647283 (237 worldwide citation)

A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes treatment of tissue with solutions prior to implantation which have been found effective in reducing calcification o ...


3
Alain Carpentier, Sophie Carpentier, Aws Nashef: Calcification mitigation of bioprosthetic implants. Baxter International, Michael C Schiffer, March 26, 1991: US05002566 (105 worldwide citation)

Calcification resistant bioprosthetic implants are made from tanned biological materials, such as porcine heart valves, bovine pericardium, human dura mater or the like, which has been impregnated with a calcification-mitigating effective amount of a ferric and/or stannic salt. The impregnated biolo ...


4
Sophie Carpentier, Alain F Carpentier, Lillian J Quintero, Victor S Packham, Jong H Wang, Stefan G Schreck: Methods and apparatuses for treating biological tissue to mitigate calcification. Baxter International, Guy L Cumberbatch, August 3, 1999: US05931969 (53 worldwide citation)

A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with a treatment solution, inducing relative tissue/solution movement, and heating the soluti ...


5
Alain F Carpentier, Sophie Carpentier, Crystal M Cunanan, Lillian Quintero, Michael N Helmus, Christine Loshbaugh, H Chris Sarner: Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby. Edwards Lifesciences Corporation, Debra D Condino, John Christopher James, April 15, 2003: US06547827 (44 worldwide citation)

A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bi ...


6
Sophie Carpentier, Alain F Carpentier, Lillian J Quintero, Victor S Packham, Jong H Wang, Stefan G Schreck: Apparatuses for treating biological tissue to mitigate calcification. Edwards Lifescience Corporation, Gay L Cumberbatch, April 3, 2001: US06210957 (39 worldwide citation)

An apparatus for treating fixed biological tissue to inhibit calcification of the biological tissue following implantation thereof in a mammalian body. The apparatus includes a container for placing the biological tissue in contact with a treatment solution, structure to induce relative tissue/solut ...


7
Alain F Carpentier, Sophie Carpentier, Crystal M Cunanan, Lillian J Quintero, Michael N Helmus, Christine Loshbaugh, H Chris Sarner: Method for treatment of biological tissues to mitigate post-implantation calcification and thrombosis. Edwards Lifesciences Corporation, Rajiv Yadav, Guy L Cumberbatch, May 8, 2007: US07214344 (27 worldwide citation)

A method of treating a biological tissue including contacting the biological tissue with an aqueous sterilizing solution, and maintaining the aqueous sterilizing solution at a temperature of about 50° C. for a time period of about 1 to 2 days. The method of treating a biological tissue may be utiliz ...


8
Alain F Carpentier, Sophie Carpentier, Crystal M Cunanan, Lillian J Quintero, Michael N Helmus, Christine Loshbaugh, H Chris Sarner: Treating biological tissues to mitigate post-implantation calcification. Edwards Lifesciences Corporation, AnneMarie Kaiser, August 7, 2012: US08236241 (18 worldwide citation)

A method of treating a biological tissue including crosslinking with glutaraldehyde; immersing the biological tissue in a first solution containing glutaraldehyde and heat in the first solution to a temperature of about 50° C. for a first period of time; immersing the biological tissue in a second s ...


9
Sophie Carpentier, Alain F Carpentier: Methods for treating implantable biological tissues to mitigate post—implantation calcification. Edwards Lifesciences Corporation, Rajiv Yadav, Guy Cumberbatch, April 18, 2006: US07029434 (13 worldwide citation)

A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with glutaraldehyde and then heating the glutaraldehyde. Alternatively, methods other than he ...


10
Sophie Carpentier, Alain F Carpentier, Lillian J Quintero, Victor S Packham, Jong H Wang, Stefan G Schreck: Apparatuses and methods for treating biological tissue to mitigate calcification. Edwards Lifesciences Corporation, Rajiv Yadav, Guy Cumberbatch, November 11, 2008: USRE040570

An apparatus for treating fixed biological tissue to inhibit calcification of the biological tissue following implantation thereof in a mammalian body. The apparatus includes a container for placing the biological tissue in contact with a treatment solution, structure to induce relative tissue/solut ...