1
Robert C Ladner, Sonia K Guterman, Bruce L Roberts, William Markland, Arthur C Ley, Rachel B Kent: Directed evolution of novel binding proteins. Protein Engineering, Iver P Cooper, June 29, 1993: US05223409 (1672 worldwide citation)

In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore o ...


2
Robert C Ladner, Sonia K Guterman, Bruce L Roberts, William Markland, Arthur C Ley, Rachel B Kent: Viruses expressing chimeric binding proteins. Protein Engineering Corporation, Iver P Cooper, April 4, 1995: US05403484 (766 worldwide citation)

In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore o ...


3
Robert C Ladner, Sonia K Guterman, Bruce L Roberts, William Markland, Arthur C Ley, Rachel B Kent: Directed evolution of novel binding proteins. Protein Engineering Corporation, Iver P Cooper, November 5, 1996: US05571698 (694 worldwide citation)

In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore o ...


4
Robert C Ladner, Sonia K Guterman, Rachel B Kent, Arthur C Ley: Generation and selection of novel DNA-binding proteins and polypeptides. Protein Engineering Corporation, Iver P Cooper, March 17, 1992: US05096815 (249 worldwide citation)

Novel DNA-binding proteins, especially repressors of gene expression, are obtained by variegation of genes encoding known binding protein and selection for proteins binding the desired target DNA sequence. A novel selection vector is used to reduce artifacts. Heterooligimeric proteins which bind to ...


5
Robert C Ladner, Sonia K Guterman, Rachel B Kent, Arthur C Ley: Generation and selection of novel DNA-binding proteins and polypeptides. Protein Engineering, Iver P Cooper, March 30, 1993: US05198346 (220 worldwide citation)

Novel DNA-binding proteins, especially repressors of gene expression, are obtained by variegation of genes encoding known binding proteins and selection for proteins binding the desired target DNA sequence. A novel selection vector may be used to reduce artifacts. Heterooligomeric proteins which bin ...


6
Arthur C Ley, Sonia K Guterman, William Markland, Rachel B Kent, Bruce L Roberts, Robert C Ladner: ITI-D1 Kunitz domain mutants as HNE inhibitors. Dyax, Wolf Greenfield & Sacks P C, July 18, 2006: US07078383 (9 worldwide citation)

Mutants of Kunitz domain 1 (ITI-D1) of human inter-α-trypsin inhibitor (ITI), are useful as inhibitors of human neutrophil elastase. Mutants characterized by one or more of the following substitutions (numbered to correspond to bovine pancreatic trypsin inhibitor, the archetypal Kunitz domain) are o ...