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Liu Xiaohai, Milton John, Smith Geoffrey Paul, Barnes Colin, Rasolonjatovo Isabelle Marie Julia, Rigatti Roberto, Wu Xiaolin, Ost Tobias William Barr, Worsley Graham John, Earnshaw David James, Turcatti Gerardo, Romieu Anthony: Preparation of templates for nucleic acid sequencing. Solexa, Liu Xiaohai, Milton John, Smith Geoffrey Paul, Barnes Colin, Rasolonjatovo Isabelle Marie Julia, Rigatti Roberto, Wu Xiaolin, Ost Tobias William Barr, Worsley Graham John, Earnshaw David James, Turcatti Gerardo, Romieu Anthony, WHITE Nina Louise, January 25, 2007: WO/2007/010251 (59 worldwide citation)

The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5' end, cleaving one ...


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Moss Bernard, Smith Geoffrey Lilley, Mackett Michael: Process for producing poxvirus recombinants for expression of foreign genes.. Us Health, June 13, 1984: EP0110385-A2 (40 worldwide citation)

Methods and compositions are provided for the use of vaccinia virus or other poxviruses as vectors for expression of foreign genes. Expression of foreign genes is obtained by combining poxvirus transcriptional regulatory sequences with uninterrupted foreign protein coding sequences in vitro to form ...


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Smith Geoffrey Paul: Method for sequencing a polynucleotide template. Solexa, Smith Geoffrey Paul, WHITE Nina Louise, January 25, 2007: WO/2007/010252 (38 worldwide citation)

The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which permit the sequential determination of nucleotide sequences in two distinct and separate regions on complementary strands of the double-stranded polynucleotide template. The two regions for s ...


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Gormley Niall Anthony, Smith Geoffrey Paul, Bentley David, Rigatti Roberto, Luo Shujun: Method of preparing libraries of template polynucleotides. Solexa, Gormley Niall Anthony, Smith Geoffrey Paul, Bentley David, Rigatti Roberto, Luo Shujun, WHITE Nina Louise, May 10, 2007: WO/2007/052006 (25 worldwide citation)

The invention provides a method of preparing a library of template polynucleotides which have common sequences at their 5' ends and at their 3' ends, and also the use of the library of templates in methods of solid-phase nucleic acid amplification.


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Smith Geoffrey Paul, Bailey David Mark Dunstan, Sanches Raquel Maria, Swerdlow Harold, Earnshaw David James: Modified polymerases for improved incorporation of nucleotide analogues. Solexa, Smith Geoffrey Paul, Bailey David Mark Dunstan, Sanches Raquel Maria, Swerdlow Harold, Earnshaw David James, BALDOCK Sharon Claire, March 17, 2005: WO/2005/024010 (19 worldwide citation)

The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3' position of the sugar moiety that are larger in size than the naturally occurring 3' hydroxyl group. Also described are methods of using the polymerases to ...


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Smith Geoffrey: Leaf-type expansible shaft with trapper bar. Nim, Pearson & Pearson, February 4, 1975: US3863857 (18 worldwide citation)

An improved leaf-type air shaft wherein one leaf member, of a plurality of expansible leaf members, is fixed on the exterior of the shaft, with a lateral edge portion forming a fixed jaw to cooperate with a trapper bar movable on a row of buttons arranged along the length of an air bladder within th ...


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Smith Geoffrey Frederick: Locks. Parkes Josiah & Sons, October 9, 1991: GB2242702-A (16 worldwide citation)

A multi-point lock has a central unit 1 with a deadbolt 10 and spring bolt 9, and end units 2, 3 housing remote bolts 4, 5 operated from the central unit through a drive linkage 32/6/7. When the remote bolts are thrown the drive linkage is blocked against withdrawal by an abutment member 40/42 engag ...



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