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Zupancic Silvo, Skrabanja Vida: Process for preparation of o-desmethylvenlafaxine and its analogue. Krka D D Novo Mesto, December 26, 2007: EP1870395-A1 (38 worldwide citation)

The present invention belongs to the field of organic chemistry and refers to a process for the preparation of O -desmethylvenlafaxine (1-[2-Dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol) and its analogues. The invention also relates to a catalytic hydrogenation of cyano-group of the substitu ...


2
Vrecer Franc, Skrabanja Vida, Zajc Natalija: Solid dosage forms comprising aliskiren and pharmaceutically acceptable salts thereof. Krka, September 24, 2008: EP1972335-A1 (5 worldwide citation)

The present invention relates to a pharmaceutical formulation comprising aliskiren or a pharmaceutically acceptable salt thereof as the active ingredient, wherein the parmaceutical formulation is present in a solid dosage form suitable for oral administration based on a granulate obtained by a hotme ...


3
Zupancic Silvio, Skrabanja Vida: Process for preparation of 0-desmethylvenlafaxine and its analogues. Krka, Zupancic Silvio, Skrabanja Vida, NOHLEN Martin, December 27, 2007: WO/2007/147564 (3 worldwide citation)

The present invention belongs to the field of organic chemistry and refers to a process for the preparation of O-desmethylvenlafaxine (l-[2-Dimethylamino)-l-(4-hydroxyphenyl)ethyl]cyclo- hexanol), its analogues and pharmaceutical acceptable salts thereof. The invention also relates to a catalytic hy ...


4
ZUPANCIC SILVO, VRECER FRANK, SKRABANJA VIDA, HVALEC MIRAN, SMRKOLJ MATEJ, GERMAN TAMARA: [fr] Préparation de sels de O-desméthylvenlafaxine, [de] Zubereitung von O-Desmethylvenlafaxin-Salzen, [en] Preparation of O-desmethylvenlafaxine salts. KRKA, November 18, 2009: EP2119695-A1 (1 worldwide citation)

[en] The present invention relates to a process for the preparation of a salt of O-desmethylvenlafaxine comprising a) dissolving or suspending O-desmethylvenlafaxine in the form of its base in a liquid medium selected from the group of solvents and suspending agents b) contacting O-desmethylvenlafax ...


5
ZUPANCIC SILVO, VRECER FRANK, SKRABANJA VIDA, HVALEC MIRAN, SMRKOLJ MATEJ, GERMAN TAMARA: [fr] Préparation de sels de O-desméthylvenlafaxine, [de] Zubereitung von O-Desmethylvenlafaxin-Salzen, [en] Preparation of O-desmethylvenlafaxine salts. KRKA, November 18, 2009: EP2119696-A1 (1 worldwide citation)

[en] The present invention relates to a process for the preparation of a salt of O-desmethylvenlafaxine comprising a) dissolving or suspending O-desmethylvenlafaxine in the form of its base in a liquid medium selected from the group of solvents and suspending agents b) contacting O-desmethylvenlafax ...


6
Vrecer Franc, Skrabanja Vida, Zajc Natalija, Gojak Urska: Solid dosage forms comprising aliskiren and pharmaceutically acceptable salts thereof. Krka Tovarna Zdravil Dd Novo Mesto, Vrecer Franc, Skrabanja Vida, Zajc Natalija, Gojak Urska, NOHLEN Martin, October 2, 2008: WO/2008/116601 (1 worldwide citation)

The present invention relates to a pharmaceutical formulation comprising aliskiren or a pharmaceutically acceptable salt thereof as the active ingredient, wherein the pharmaceutical formulation is present in a solid dosage form suitable for oral administration based on a granulate obtained by a hot- ...


7
Sedmak Gregor, Kramar Andrejka, Vrecer Franc, Skrabanja Vida: Solid pharmaceutical composition comprising tamsulosin. Krka Tovarna Zdravil D D Novo, April 15, 2009: EP2047847-A1

The present invention relates to a stable pharmaceutical composition comprising tamsulosin or a pharmaceutically acceptable salt or solvate thereof in a solid dosage form and to a process for preparing such a composition.


8
STUKELJ MITJA, VRECER FRANC, SKRABANJA VIDA: [fr] Processus de granulation à humidité activée, [de] Flüssigkeitsaktiviertes Granulationsverfahren, [en] Moisture-activated granulation process. KRKA TOVARNA ZDRAVIL D D NOVO, August 11, 2010: EP2216020-A1

[en] The present invention relates to a moisture-activated granulation process for the manufacture of a pharmaceutical dosage form containing a moisture-sensitive active substance such as aliskiren, said process comprising: a) mixing the active ingredient with one or more dry excipients such as dilu ...


9
STUKELJ MITJA, VRECER FRANC, SKRABANJA VIDA, KUKEC SIMON, FERLAN ANDREJ: Moisture-activated granulation process, Flüssigkeitsaktiviertes Granulationsverfahren, Processus de granulation à humidité activée. KRKA TOVARNA ZDRAVIL D D NOVO MESTO, July 6, 2011: EP2340820-A1

A moisture-activated granulation process for the manufacture of a pharmaceutical dosage form containing at least one moisture-sensitive active substance selected from the group consisting of aliskiren and its pharmaceutically acceptable salts, said process comprising: a) mixing the active substance( ...


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