1
Sigmar Klose, Fritz Stahler, Hans Lange, Wolfgang Kleemann: Method for carrying out analytical determinations. Boehringer Mannheim, Felfe & Lynch, May 7, 1985: US04515889 (90 worldwide citation)

The present invention provides a process for carrying out analytical determinations by mixing and incubating a sample solution with at least one reagent and optically measuring a parameter in the incubated reaction mixture. The mixing, incubating and measuring are carried out during the action of a ...


2
Rolf Deeg, Eberhard Maurer, Reiner Babiel, Sigmar Klose, Bernhard Kopfer: Method for the metered application of a biochemical analytical liquid to a target. Boehringer Mannheim, Nikaido Marmelstein Murray & Oram, August 16, 1994: US05338688 (83 worldwide citation)

A method for the metered application of a biochemical analytical liquid to a target, wherein the liquid is ejected in small quantities on to the target through a jet from a jet chamber by a procedure in which a partial volume of the liquid in the jet chamber is evaporated and expanded for a short ti ...


3
Hermann Edelmann, Manfred Pasch, Sigmar Klose, Hans Peter Haar, Karlheinz Mann: Centrifugal analyzer rotor unit and insert elements. Boehringer Mannheim, Sprung Horn Kramer & Woods, June 26, 1984: US04456581 (68 worldwide citation)

A rotor unit for a centrifugal analyzer comprises a rotatably driven circular rotor base; and a rotor head comprising a plurality of insert elements each having at least one chamber sample for the reception of a sample liquid, at least one measuring chamber radially outwardly from the associated sam ...


4
Peter Scheibe, Erich Bernt, Sigmar Klose: Method and reagent for the enzymatic determination of enzyme substrates. Boehringer Mannheim, Felfe & Lynch, May 14, 1985: US04517287 (42 worldwide citation)

The present invention provides a reagent for the enzymatic determination of an enzyme substrate, containing a system for the determination of the substrate, which comprises at least one enzyme, at least one buffer substance and at least one indicator substance and optionally contains adjuvants, wher ...


5
Rolf Deeg, Eberhard Maurer, Sigmar Klose, Bernhard Kopfer, Reiner Babiel: Analysis element and process for its manufacture. Boehringer Mannheim, Nikaido Marmelstein Murray & Oram, January 3, 1995: US05378638 (37 worldwide citation)

An analysis element for the determination of an analyte in a liquid sample, especially for medicinal uses. A carrier layer (2) contains, in a reagent domain (4), a reagent applied in a defined pattern by an ink-jet process. The pattern comprises several sets (A, B, C) of compartments (11-20), the co ...


6
Hermann Edelmann, Anton Pasch, Sigmar Klose, Hans Peter Haar, Karlheinz Mann: Centrifugal analyzer rotor unit and insert elements. Boehringer Mannheim, Sprung Horn Kramer & Woods, March 21, 1989: US04814144 (28 worldwide citation)

A rotor unit for a centrifugal analyzer comprises a rotatably-driven circular rotor base; and a rotor head comprising a plurality of insert elements each having at least one chamber sample for the reception of a sample liquid, at least one measuring chamber radially outwardly from the associated sam ...


7
Sigmar Klose, Fritz Stahler: Process for carrying out analytical determinations and means for carrying out this process. Boehringer Mannheim, Felfe & Lynch, April 10, 1990: US04916078 (25 worldwide citation)

The present invention provides a process for carrying out an analytical determination by mixing and incubating a sample solution with at least one reagent and measuring a parameter in the reaction mixture, the sample solution being transported from an application point to a measurement point, wherei ...


8
Sigmar Klose, Manfred Pasch, Wolfgang Kleemann, Friedhelm Vieth, Herbert Buschek: Process and device for the control and mixing of a fluid current subjected to centrifugal force. Boehringer Mannheim, Felfe & Lynch, December 10, 1985: US04557600 (24 worldwide citation)

A process and a device for the centrifugal control and mixing of a limited volumes of fluid, especially in the rotor of a centrifugal analyzer, has at least one baffle chamber, in a flow canal for the fluid the volume of which is greater than the volume of fluid. It is so shaped that, when the devic ...


9
Sigmar Klose, Fritz Stahler: Process for carrying out analytical determinations and means for carrying out this process. Boehringer Mannheim, Felfe & Lynch, February 6, 1990: US04898832 (20 worldwide citation)

A process for carrying out an analytical determination by mixing and incubating a sample solution with at least one reagent and measuring a parameter in the reaction mixture, the sample solution being transported from an application point to a measurement point, wherein a sample solution is first tr ...


10
Sigmar Klose, Herbert Buschek, Helmut Schlumberger: Compositions and method for reducing turbidity in samples. Boehringer Mannheim, Sprung Felfe Horn Lynch & Kramer, August 4, 1981: US04282001 (20 worldwide citation)

For the removal of turbidities in reaction mixtures clouded by sample material, especially for photometric measurement, there are added to the reaction mixture: