1
Sierra David H, Luck Edward E, Brown Dennis M: Surgical adhesive material.. Project Hear, Matrix Pharma, November 8, 1989: EP0341007-A2 (42 worldwide citation)

The present invention provides a surgical adhesive comprising, in an aqueous composition, patient autogenous plasma, collagen, thrombin, and optionally, an antifibrinolytic agent. The present adhesive is formed from the patient's plasma without the use of any added reagents for concentration or isol ...


2
Sierra David H, Luck Edward E, Brown Dennis M: Fibrin/collagen membrane material for biomedical use.. Matrix Pharma, May 13, 1992: EP0485210-A2 (29 worldwide citation)

Gel membranes are provided by gelling fibrinogen with thrombin by itself or in combination with gelation of collagen. After dehydration, the resulting membranes may be used as dressings, temporary skin grafts, or the like. The gels may be used without dehydration for drug delivery or tissue regenera ...


3
Sierra David H: Differentially biodegradable biomedical implants. Otogen, July 23, 1997: EP0784490-A1 (1 worldwide citation)

The current invention is a biomedical implant comprising a biomedical matrix material and a biodegradable porosifying agent. As the porosifying agent degrades in situ, an implant with an interconnecting network is formed. The resultant mechanically stable implant allows for tissue and fluid influx i ...


4
Prior Jeffrey J, Sierra David H, Wallace Donald G, Delustro Frank A: Compositions contenant de la thrombine et du collagene microfibrillaire, Compositions containing thrombin and microfibrillar collagen. Cohesion Technologies, Angiotech Pharmaceuticals, BORDEN LADNER GERVAIS, May 26, 2009: CA2295247

The present invention relates to thrombin-containing hemostatic compositions, their preparation and use. In particular, it relates to hemostatic compositions comprising stabilized thrombin and microfibrillar collagen in an aqueous medium. In a preferred embodiment of the present invention, the compo ...


5
Sierra David H: Mplants biomedicaux biodegradables de facon differentielle, Differentially biodegradable biomedical implants. Otogen Corporation, Angiotech Pharmaceuticals, BORDEN LADNER GERVAIS, April 11, 1996: CA2201526

The current invention is a biomedical implant comprising a biomedical matrix material and a biodegradable porosifying agent. As the porosifying agent degrades in situ, an implant with an interconnecting network is formed. The resultant mechanically stable implant allows for tissue and fluid influx i ...


6
Luck Edward E, Brown Dennis M, Sierra David H: Adhesif pour emploi en chirurgie, Surgical adhesive material. Project Hear, Matrix Pharmaceuticals, Matrix Pharmaceuticals, Cohesion Corporation, FETHERSTONHAUGH & CO, July 29, 1997: CA1339090

The present invention provides a surgicaladhesive comprising, in an aqueous composition, patientautogenous plasma, collagen, thrombin, and optionally,an antifibrinolytic agent. The present adhesive isformed from the patient's plasma without the use of anyadded reagents for concentration or isolation ...


7
Sierra David H, Freeman Abby, Delustro Frank, Prior Jeff: Lyophilized collagen-based biomaterials, process of preparation and uses thereof. Cohesion, July 19, 2000: EP1019106-A1

This invention pertains to methods of lyophilizing collagen-based biomaterials, which lyophilates, when reconstituted, retain hemostatic activity and can be extruded. This invention also pertains to methods of radiation-sterilization of lyophilized collagen-based biomaterials.


8
Sierra David H: Thrombin preparation and products and fibrin sealant methods employing same. Baxter Int, December 27, 2000: EP1061931-A2

The invention employs liposomes having an outer surface presenting both acidic and basic polar groups, for example phosphatidyl for rapid, high yield generation of thrombin from prothrombin-containing material. The source material for the prothrombin can be the subject to be treated with the product ...


9
Sierra David H: Tissue sealant compositions and methods of use thereof. Cohesion Corporation, Sierra David H, sAXFORD Laurie A, August 21, 1997: WO/1997/029792

Novel tissue sealant compositions are disclosed herein which can be formulated as a single-component. The compositions contain as essential elements thromboplastin and fibrinogen. Additional blood clotting factors such as Factors II, V, VII, X, and XIII can also be added. Also provided are methods f ...


10
Prior Jeffrey J, Sierra David H, Wallace Donald G, Delustro Frank A: Compositions containing thrombin and microfibrillar collagen. Cohesion Technologies, Prior Jeffrey J, Sierra David H, Wallace Donald G, Delustro Frank A, AXFORD Laurie A, December 23, 1998: WO/1998/057678

The present invention relates to thrombin-containing hemostatic compositions, their preparation and use. In particular, it relates to hemostatic compositions comprising stabilized thrombin and microfibrillar collagen in an aqueous medium. In a preferred embodiment of the present invention, the compo ...