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Conrad P Dorn, Paul E Finke, Jeffrey J Hale, Malcolm MacCoss, Sander G Mills, Shrenik K Shah, Mark Stuart Chambers, Timothy Harrison, Tamara Ladduwahetty, Brian John Williams: Morpholine and thiomorpholine tachykinin receptor antagonists. Merck & Co, J Eric Thies, David L Rose, February 17, 1998: US05719147 (65 worldwide citation)

Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertensi ...


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William K Hagmann, Linus S Lin, Shrenik K Shah, Ravindra N Guthikonda, Hongbo Qi, Linda L Chang, Ping Liu, Helen M Armstrong, James P Jewell, Thomas J Lanza Jr: Substituted amides. Merck & Co, Catherine D Fitch, Melvin Winokur, December 6, 2005: US06972295 (31 worldwide citation)

Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs ...


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James B Doherty, Conrad P Dorn, Paul E Finke, William K Hagmann, Malcolm MacCoss, Shrenik K Shah: Substituted azetidinones as anti-inflammatory and antidegenerative agents. Merck & Co, Curtis C Panzer, Raymond M Speer, July 20, 1993: US05229381 (31 worldwide citation)

New substituted azetidinones of the general formula (A') which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. ##STR1##


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Shrenik K Shah: Spiro-substituted azacycles as neurokinin-3 antagonists. Merck & Co, Curtis C Panzer, David L Rose, July 18, 1995: US05434158 (30 worldwide citation)

Disclosed are spiro-substituted azacycles of formula I ##STR1## are selective neurokinin-3 antagonists useful in the treatment of CNS disorders.


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Ravindra N Guthikonda, Stephan K Grant, Malcolm Maccoss, Shrenik K Shah, Kothandaraman Shankaran, Charles G Caldwell, Philippe L Durette: Cyclic amidine analogs as inhibitors of nitric oxide synthase. Merck & Co, Curtis C Panzer, David L Rose, May 13, 1997: US05629322 (30 worldwide citation)

Disclosed herein are compounds of Formula I ##STR1## and pharmaceutically acceptable salts thereof which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders, including neurodegenerative disorders, disorders of gastrointestinal motility and inflammation. T ...


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James B Doherty, Paul E Finke, William K Hagmann, Amy L Kissinger, Malcolm MacCoss, Shrenik K Shah: Substituted azetidinones as anti-inflammatory and antidegenerative agents. Merck & Co, Curtis C Panzer, David L Rose, Joseph F DiPrima, September 20, 1994: US05348953 (27 worldwide citation)

New substituted azetidinones of the general formula (I) which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. ##STR1##


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Malcolm Maccoss, Sander G Mills, Shrenik K Shah, Yuan Ching P Chiang, Patrick T Dunn, Hiroo Koyama: Spiro-substituted azacycles as neurokinin antagonists. Merck & Co, Richard C Billups, David L Rose, January 11, 2000: US06013652 (24 worldwide citation)

Disclosed are spiro-substituted azacycles of formula I are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma. In particular compounds of formula I are shown to be neurokinin antagonists.



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