1
Vinod F Patel, Benny Askew, Shon Booker, Guoqing Chen, Lucian V DiPietro, Julie Germain, Gregory J Habgood, Qi Huang, Tae Seong Kim, Aiwen Li, Nobuko Nishimura, Rana Nomak, Babak Riahi, Chester Chenguang Yuan, Daniel Elbaum: Substituted amine derivatives and methods of use. Amgen, Joseph W Bulock, September 5, 2006: US07102009 (24 worldwide citation)

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseas ...


2
Benny Askew, Jeffrey Adams, Shon Booker, Guoqing Chen, Lucian V DiPietro, Daniel Elbaum, Julie Germain, Stephanie D Geuns Meyer, Gregory J Habgood, Michael Handley, Qi Huang, Tae Seong Kim, Aiwen Li, Nobuko Nishimura, Rana Nomak, Vinod F Patel, Babak Riahi, Joseph L Kim, Ning Xi, Kevin Yang, Chester Chenguang Yuan: Substituted alkylamine derivatives and methods of use. Amgen, Joseph W Bulock, April 12, 2005: US06878714 (24 worldwide citation)

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseas ...


3
Shon Booker, Noel D Angelo, Julie Germain, Jean Christophe Harmange, Tae Seong Kim, Michele Potashman: Bis-aryl amide derivatives and methods of use. Amgen, July 20, 2010: US07759344 (14 worldwide citation)

Selected compounds are effective for prophylaxis and treatment of diseases, such as c-Met mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases a ...


4
Guoqing Chen, Jeffrey Adams, Jean Bemis, Shon Booker, Guolin Cai, Lucian Di Pietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Stephanie Geuns Meyer, Michael Handley, Qi Huang, Joseph L Kim, Tae Seong Kim, Alexander Kiselyov, Xiaohu Ouyang, Vinod F Patel, Leon M Smith, Markian Stec, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael Croghan: Substituted alkylamine derivatives and methods of use. Amgen, Joseph W Bulock, February 7, 2006: US06995162 (13 worldwide citation)

Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis a ...


5
Tae Seong Kim, Steven Bellon, Shon Booker, Noel D Angelo, Celia Dominguez, Ingrid Fellows, Matthew Lee, Longbin Liu, Elizabeth Rainbeau, Aaron C Siegmund, Andrew Tasker, Ning Xi, Yuan Cheng: Substituted heterocycles and methods of use. Amgem, January 26, 2010: US07652009 (12 worldwide citation)

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and ...


6
Michele Potashman, Tae Seong Kim, Steven Bellon, Shon Booker, Yuan Cheng, Joseph L Kim, Andrew Tasker, Ning Xi, Shimin Xu, Jean Christophe Harmange, George Borg, Matthew Weiss, Brian L Hodous, Russell Graceffa, William H Buckner, Craig E Masse, Deborah Choquette, Matthew W Martin, Julie Germain, Lucian V DiPietro, Stuart C Chaffee, Joseph J Nunes, John L Buchanan, Gregory J Habgood, David C McGowan, Douglas A Whittington, Daniel La, Vinod F Patel: Compounds and methods of use. Amgen, Joseph W Bulock, Ronald S Hermenau, October 14, 2008: US07435823 (9 worldwide citation)

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and ...


7
Daniel Elbaum, Benny C Askew Jr, Shon Booker, Julie Germain, Gregory J Habgood, Michael Handley, Tae Seong Kim, Aiwen Li, Nobuko Nishimura, Vinod F Patel, Chester Chenguang Yuan, Joseph L Kim, Guolin Cai, Guoqing Chen, Michael Croghan, Lucian V Di Pietro, Celia Dominguez, Qi Huang, Leon M Smith II, Andrew Tasker, Ning Xi, Shimin Xu: Substituted arylamine derivatives and methods of use. Amgen, Joseph W Bulock, September 5, 2006: US07101868 (8 worldwide citation)

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment ...


8
Tae Seong Kim, David Bauer, Steven Bellon, Alessandro Boezio, Shon Booker, Deborah Choquette, Derin C D Amico, Noel D Angelo, Celia Dominguez, Ingrid M Fellows, Julie Germain, Russell Graceffa, Jean Christophe Harmange, Satoko Hirai, Daniel La, Matthew Lee, Longbin Liu, Mark H Norman, Michele Potashman, Philip Roveto, Aaron C Siegmund, Ning Xi, Kevin Yang: Substituted amide derivatives and methods of use. Amgen, Olga Mekhovich, Joseph W Bulock, January 3, 2012: US08088794 (7 worldwide citation)

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and ...


9
Tae Seong Kim, Shon Booker, Celia Dominguez, Jean Christophe Harmange: Substituted amide derivatives and methods of use. Amgen, December 28, 2010: US07858623 (7 worldwide citation)

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and ...


10
Shon Booker, Tae Seong Kim, Hongyu Liao, Longbin Liu, Mark H Norman, Emily Anne Peterson, Markian Stec, Nuria A Tamayo: Imidazopyridazine inhibitors of PI3 kinase for cancer treatment. Amgen, Todd M Crissey, October 26, 2010: US07820665 (3 worldwide citation)

The present invention relates to imidazopyridazine compounds of Formula I, such as representative structure A, or a pharmaceutically acceptable salt thereof, that inhibit phosphoinositide 3-kinase; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical co ...