1
Shmuel Zalipsky: Active carbonates of polyalkylene oxides for modification of polypeptides. Enzon, John P White, Craig J Arnold, June 16, 1992: US05122614 (375 worldwide citation)

Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted ...


2
Shmuel Zalipsky: Active carbonates of polyalkylene oxides for modification of polypeptides. Enzon, Michael N Mercanti, March 18, 1997: US05612460 (214 worldwide citation)

Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted ...


3
Shmuel Zalipsky: Active carbonates of polyalkylene oxides for modification of polypeptides. Enzon, Michael N Mercanti, June 28, 1994: US05324844 (172 worldwide citation)

Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted ...


4
Shmuel Zalipsky: Process for preparing active carbonates of polyalkylene oxides for modification of polypeptides. Enzon, Roberts & Mercanti L, September 15, 1998: US05808096 (96 worldwide citation)

Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted ...


5
Kwang Nho, Shmuel Zalipsky, Frank Davis: Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute. Enzon, Lerner David Littenberg Krumholz & Mentlik, August 10, 1993: US05234903 (83 worldwide citation)

The present invention relates to chemically modified hemoglobin produced by a novel and efficient method in which stroma-free hemoglobin is first effectively deoxygenated and reduced and then conjugated with a polyalkylene oxide such as polyethylene glycol (PEG) under conditions which maintain the s ...


6
Kwang Nho, Shmuel Zalipsky, Frank Davis: Chemically modified hemoglobin as an effective, stable, non-immunogenic red blood cell substitute. Enzon, Michael N Mercanti, January 31, 1995: US05386014 (46 worldwide citation)

The present invention relates to chemically modified hemoglobin produced by a novel and efficient method in which stroma-free hemoglobin is first effectively deoxygenated and reduced and then conjugated with a polyalkylene oxide such as polyethylene glycol (PEG) under conditions which maintain the s ...