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Yanagisawa Hiroaki, Shimoji Yasuo, Fujimoto Koichi, Kanazaki Takuro, Anemiya Yoshiya, Koike Hiroyuki, Sada Toshio: 1-biphenylimidazole derivatives, their preparation and their therapeutic use.. Sankyo, September 16, 1992: EP0503785-A1 (29 worldwide citation)

Compounds of formula (I): in which: R is alkyl or alkenyl; R and R are hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, or aryl fused to cycloalkyl; R is hydrogen, alkyl, alkanoyl, alkenoyl, arylcarbonyl, alkoxycarbonyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothienyl, tetrahydrofury ...


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Takiguchi Yo C O Sankyo Compan, Ohsumi Jun C O Sankyo Company, Shimoji Yasuo C O Sankyo Compa, Sasagawa Kazuhiko C O Sankyo C: Method of treating cachexia and certain new compounds for use in this method.. Sankyo, December 20, 1989: EP0347252-A2 (8 worldwide citation)

Compounds of formula (I): [in which: Y represents a group of formula the dotted line is a double or single bond; R is hydrogen, alkyl or aryl; R is hydrogen or halogen; R is alkyl or cycloalkyl; R is hydrogen, alkyl, hydroxy or halogen; R is hydrogen, alkyl, hydroxy, oxygen or halogen; and R is hydr ...


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Yanagisawa Hiroaki C O Sankyo, Fujimoto Koichi C O Sankyo Com, Shimoji Yasuo C O Sankyo Compa, Kanazaki Takuro C O Sankyo Com, Iwata Nobuyoshi C O Sankyo Com, Kubo Yoshiko C O Sankyo Compan: Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders.. Sankyo, February 6, 1991: EP0411912-A2 (8 worldwide citation)

Compounds of formula (I): [in which: A is a group of formula (II) or (III): R, R and R are hydrogen, lower alkyl or halogen; R is hydrogen, lower alkyl or aralkyl; R and R are hydrogen or lower alkyl; R and R are hydrogen or lower alkyl; or R and R together represent alkylene; and m is 1 or 2; ] and ...


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Yanagisawa Hiroaki C O Sankyo, Fujimoto Koichi C O Sankyo Com, Shimoji Yasuo C O Sankyo Compa, Kanazaki Takuro C O Sankyo Com, Koike Hiroyuki C O Sankyo Comp, Nishino Hiroshi C O Sankyo Com: 1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders.. Sankyo, January 31, 1990: EP0353032-A1 (4 worldwide citation)

Compounds of formula (I): [in which: R is aryl or aromatic heterocyclic; R and R are hydrogen, alkyl, alkoxy, halogen, phenyl, phenoxy, C1 - C6 alkylthio, phenylthio, C1 - C6 haloalkyl, cyano or nitro, or together are alkylene optionally containing oxygen; R is hydrogen, aliphatic acyl, cycloalkylca ...


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Yanagisawa Hiroaki C O Sankyo, Amemiya Yoshiya C O Sankyo Com, Kanazaki Takuro C O Sankyo Com, Shimoji Yasuo C O Sankyo Compa, Koike Hiroyuki C O Sankyo Comp, Sada Toshio C O Sankyo Company: Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease.. Sankyo, June 22, 1994: EP0603001-A1 (3 worldwide citation)

Compounds of formula (I) : [wherein: A represents a group (IIa), (IIb) or (IIc) : R is alkyl, alkenyl, cycloalkyl or a group of formula R-Y-R-, where: R is hydrogen, alkyl, or cycloalkyl, R is a single bond or alkylene, and Y is oxygen, sulphur or imino group; R is hydrogen, halogen, Optionally subs ...


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Kawamoto Isao, Shimoji Yasuo, Sugano Osamu, Kojima Katsuhiko: Derivative of mercaptpyrrolidine. Sankyo, April 24, 2001: JP2001-114759 (3 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a mercaptpyrrolidine compound useful as a production intermediate for side chain part on the 2 position of an antibacterial agent based on carbapenem. SOLUTION: The derivative is a mercaptpyrrolidine compound or its salt expressed by general formula (1) (n is 0, 1 or ...


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Kawamoto Isao, Shimoji Yasuo, Ishikawa Katsuya, Kojima Katsuhiko, Yasuda Hiroshi, Ohya Satoshi, Utsui Yukio: 1-methylcarbapenem derivatives. Sankyo, December 9, 1998: EP0882728-A1 (2 worldwide citation)

A 1-methylcarbapenem compound represented by the following formula (I): wherein R represents a hydrogen atom or a lower alkyl group; R represents a hydrogen atom or an ester residue; and A represents a substituted prolylaminopyrrolidin-1-ylcarbonyl, substituted aminoalkanoylaminopyrrolidin-1-ylcarbo ...


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Yanagisawa Hiroaki C O Sankyo, Shimoji Yasuo C O Sankyo Compa, Amomiya Yoshiya C O Sankyo Com, Kanazaki Takuro C O Sankyo Com, Koike Hiroyuki C O Sankyo Comp, Sada Toshio C O Sankyo Company: 4-carboxyimidazoles as angiotensin ii antagonists and their thrapeutic use.. Sankyo, December 8, 1993: EP0573218-A2 (2 worldwide citation)

Compounds of formula (I): [in which: R is hydrogen, alkyl, cycloalkyl or alkanoyl; R is a single bond, alkylene or alkylidene; R and R are each hydrogen or alkyl; R is carboxy or tetrazol-5-yl; and X is oxygen or sulphur]; and pharmaceutically acceptable salts and esters thereof are AII antagonists ...


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