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Matsuo Masaaki, Hagiwara Daijiro, Manabe Takashi, Nobukiyo Konishi, Shigenaga Shinji, Murano Kenji, Matsuda Hiroshi, Miyake Hiroshi: Piperazine derivatives as tachykinin antagonists.. Fujisawa Pharmaceutical Co, May 31, 1995: EP0655442-A1 (56 worldwide citation)

A compound of the following general formula : wherein X is carbonyl or sulfonyl; Y is bond or lower alkylene; R is halogen, lower alkyl, halo(lower)alkyl, aryloxy, nitro or amino which may have 1 or 2 and same or different substituent(s) selected from lower alkyl, acyl and lower alkanesulfonyl; R is ...


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Matsuo Masaaki, Manabe Takashi, Shigenaga Shinji, Matsuda Hiroshi: New indolylpiperidine compounds, processes for the preparation thereof and pharmaceutical composition comprising the same.. Fujisawa Pharmaceutical Co, July 19, 1989: EP0324431-A1 (7 worldwide citation)

The present invention relates to new indolylpiperidine compounds represented by the following general formula (I): wherein R is aryl substituted with substituent(s) selected from the group consisting of hydroxy, protected hydroxy, halogen and lower alkoxy, A is lower alkylene, and B is lower alkenyl ...


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Shigenaga Shinji, Higuchi Koichi, Mukoyoshi Koichiro, Tanabe Daisuke, Inoue Takayuki, Sato Kentaro, Tenda Yoshiyuki, Tsujimoto Susumu: Thiazolylbenzofuran derivatives as leukotriene and prostaglandin d2 receptor antagonists. Astellas Pharma, Shigenaga Shinji, Higuchi Koichi, Mukoyoshi Koichiro, Tanabe Daisuke, Inoue Takayuki, Sato Kentaro, Tenda Yoshiyuki, Tsujimoto Susumu, MORITA Hiroshi, May 4, 2006: WO/2006/046683 (2 worldwide citation)

There is provided a compound of the formula (I): wherein R1 is lower alkyl, R2 is lower alkyl substituted with a substituent selected from the group consisting of carboxy and esterified carboxy, and R3 is lower alkoxy substituted with lower alkylcarbamoyl, or a pharmaceutically acceptable salt there ...


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Take Kazuhiko, Konishi Nobukiyo, Shigenaga Shinji, Kayakiri Natsuko, Azami Hidenori, Eikyu Yoshiteru, Nakai Kazuo, Ishida Junya, Morita Masataka: Piperazine derivatives. Fujisawa Pharmaceutical, Take Kazuhiko, Konishi Nobukiyo, Shigenaga Shinji, Kayakiri Natsuko, Azami Hidenori, Eikyu Yoshiteru, Nakai Kazuo, Ishida Junya, Morita Masataka, TABUSHI Eiji, June 22, 2000: WO/2000/035915 (1 worldwide citation)

This invention relates to piperazine derivatives of formula (I) wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing ...


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Matsuo Masaaki, Manabe Takashi, Shigenaga Shinji, Matsuda Hiroshi: Thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same.. Fujisawa Pharmaceutical Co, May 24, 1989: EP0316820-A1

A thiazole compound of the formula : wherein R is amino or acylamino, R is ar(lower)alkoxy, and A is lower alkylene, and a pharmaceutically acceptable salt thereof, processes for the preparation thereof and pharmaceutical composition comprising the same


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Matsuo Masaaki, Okumura Kazuo, Shigenaga Shinji, Nishimura Hiroaki, Matsuda Hiroshi, Hagiwara Daijiro, Terasaka Tadashi: Thiazolybenzofuran derivatives and their use as srs-a and leukotiene antagonists. Fujisawa Pharmaceutical Co, January 9, 2002: EP1170009-A2

This invention relates to novel thiazolylbenzofuran derivatives of formula (I) wherein R is lower alkyl, L is single bond or lower alkylene optionally substituted with aryl, oxo or hydroxy, and Q is a heterocyclix group optionally substituted with one or more suitable substituent(s) or its salt, whi ...


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Matsuo Masaaki, Okumura Kazuo, Shigenaga Shinji: Noval chemical compound. Fujisawa Pharmaceutical, ma chongde, March 3, 1999: CN97191798

This invention relates to novel thiazolylbenzofuran derivatives of formula (I) wherein R1 is lower alkyl, L is single bond or lower alkylene optionally substituted with aryl, oxo or hydroxy, and Q is a heterocyclic group optionally substituted with one or more suitable substituent(s); or lower alkox ...


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Miyake Hiroshi, Take Kazohiko, Shigenaga Shinji: Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists. Fujisawa Pharmaceutical, tan mengsheng, September 13, 2000: CN98808116

This invention relates to piperazine derivatives of formula (I), wherein Y is bond or lower alkylene, R is aryl which may have substituent(s), R is aryl or indolyl, each of which may have substituent(s), R is hydrogen or lower alkyl, and R is as defined in the description, and its pharmaceutically a ...


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Take Kazuhiko, Konishi Nobukiyo, Shigenaga Shinji: Piperazine derivatives. Fujisawa Pharmaceutical, ma chongde, February 6, 2002: CN99816132

This invention relates to piperazine derivatives of formula I wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing T ...