1
Kettner Charles Adrian, Shenvi Ashokkumar Bhikkappa: Peptide boronic acid inhibitors of trypsin-like proteases.. Du Pont, December 7, 1988: EP0293881-A2 (124 worldwide citation)

Peptides comprising C-terminal boronic acid derivatives of lysine, ornithine, and arginine, homoarginine and corresponding isothiouronium analogs thereof, of the formula are reversible inhibitors of trypsin-like serine proteases such as thrombin, plasma kallikrein and plasmin.


2
Jacobs Robert Toms Zeneca Inc, Shenvi Ashokkumar Bhikkappa Ze: 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists.. Zeneca, December 28, 1994: EP0630887-A1 (61 worldwide citation)

The present invention concerns the novel aryl substituted heterocycles of formula I, set out below, wherein R, R and R have the values defined herein, which antagonize the pharmacological actions of one of the endogenous neuropeptide tachykinins at the neurokinin 2 (NK2) receptor making them useful ...


3
Jacobs Robert Toms Zeneca Inc, Shenvi Ashokkumar Bhikkappa Ze: N-alkyl substituted piperidine-derivatives with neurokinin receptor antagonist activity.. Zeneca, November 23, 1994: EP0625509-A1 (36 worldwide citation)

The present invention concerns the novel alkyl substituted heterocycles of formula I, set out below, wherein Q, Q, Q and R have the values defined herein, which antagonize the pharmacological actions of one of the endogenous neuropeptide tachykinins at the neurokinin 2 (NK2) receptor making them use ...


4
Shenvi Ashokkumar Bhikkappa, Kettner Charles A: Alpha-aminoboronic acid peptides.. Du Pont, June 19, 1985: EP0145441-A2 (33 worldwide citation)

Peptides comprising C-terminal alpha -aminoboronic acid residues are potent, reversible inhibitors of proteolytic enzymes.


5
Becker Christopher, Dembofsky Bruce, Jacobs Robert, Kang James, Ohnmacht Cyrus, Rosamond James, Shenvi Ashokkumar Bhikkappa, Simpson Thomas, Woods James: Novel lactams and uses thereof. Astrazeneca, Becker Christopher, Dembofsky Bruce, Jacobs Robert, Kang James, Ohnmacht Cyrus, Rosamond James, Shenvi Ashokkumar Bhikkappa, Simpson Thomas, Woods James, ASTRAZENECA, April 15, 2004: WO/2004/031154 (20 worldwide citation)

Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid ß protein production and neurological disorders such as Alzheimer's disease.. These compounds inhibit &ggr; secretase and thereby inhib ...


6
Shenvi Ashokkumar Bhikkappa Ze, Jacobs Robert Toms Zeneca Inc, Miller Scott Carson Zeneca Inc, Ohnmacht Cyrus John Jr Zeneca, Veale Chris Allan Zeneca Inc: Heterocyclic compounds.. Zeneca, November 8, 1995: EP0680962-A2 (15 worldwide citation)

Compounds of formula I wherein Q, Q, Q, Q, Q and T have any of the meanings given in the specification, their N-oxides, their quaternary ammonium salts, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed ...


7

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Hussain Munir Alwan, Shenvi Ashokkumar Bhikkappa: Peptide-drug compositions containing alpha-aminoboronic acid derivatives.. Du Pont, November 15, 1989: EP0341661-A2 (3 worldwide citation)

Pharmaceutical compositions of peptide or protein drugs are provided which contain alpha -aminoboronic acid derivatives to stabilize these drugs during their absorption through various mucosae, such as nasal and buccal mucosae, and eventually improve their systemic bioavailability.


9
Miller Scott Carson, Jacobs Robert Toms, Shenvi Ashokkumar Bhikkappa: Substituted heterocycles. Zeneca, October 30, 1996: EP0739891-A2 (2 worldwide citation)

Compounds of formula I wherein Q, Q, Q, Q and Q have any of the meanings given in the specification, their N-oxides, and their pharmacuetically acceptable salts are nonpeptide antagonists NKA, useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for prep ...


10
Shenvi Ashokkumar Bhikkappa, Ciganek Engelbert: Process and intermediates of octahydrobenzofuro(3,2-e)isoquinolines.. Du Pont, July 6, 1983: EP0083093-A2

Process for preparing analgesic and narcotic antagonistic isoquinolines comprising: (a) contacting and reacting a lithiated anisole or alkyl phenyl ether, optionally substituted at the 3-position to the lithium atom, with a 4-piperidone to yield a 4-aryl-4-piperidinol; (b) dehydrating the piperidino ...